analog of folic acid in which the 9-methyl & 10-amino groups are reversed; structure
Also Known As:
N-(p-(((2-amino-4-hydroxy-6-pteridinyl)amino)methyl)benzoyl)glutamic acid; N-(4-(((2-amino-1,4-dihydro-4-oxo-6-pteridinyl)amino)methyl)benzoyl)-L-glutamic acid
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Bio-Agent Context: Research Results
|1. ||Leukemia L1210
- "A series of 5,8-dideaza analogues of folic acid, isofolic acid, aminopterin, and isoaminopterin were evaluated for inhibition of thymidylate synthase, TS, from mouse L1210 leukemia cells with 10-propargyl-5,8-dideazafolic acid, CB3717, 4a, as the reference inhibitor.
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