5-hydroxymethylfurfural (hydroxymethylfurfural)

has antisickling activity; HMF is the causative component in honey that affects the presystemic metabolism and pharmacokinetics of GZ in-vivo

Also Known As:

hydroxymethylfurfural; 5-(hydroxymethyl)furfural; 5-HM-2-F cpd; 5-HMF cpd; 5-hydroxymethyl furfural; 5-hydroxymethyl-2-furaldehyde; 5-hydroxymethyl-2-furfural; 5-hydroxymethylfuraldehyde; 5-hydroxymethylfurfuraldehyde; Aes-103; 5-(hydroxymethyl)-2-furaldehyde

Networked: 181 relevant articles (5 outcomes, 15 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Dumesic, James A: 4 articles (01/2019 - 06/2006)
2.	Wintersteiger, Reinhold: 4 articles (02/2013 - 04/2010)
3.	Glatt, Hansruedi: 4 articles (12/2012 - 06/2009)
4.	Zhang, Jian: 3 articles (12/2020 - 01/2017)
5.	Chen, Biaohua: 3 articles (09/2018 - 02/2012)
6.	Huang, Chongpin: 3 articles (09/2018 - 02/2012)
7.	Hensen, Emiel J M: 3 articles (01/2016 - 01/2011)
8.	Ebitani, Kohki: 3 articles (01/2014 - 11/2009)
9.	Nishimura, Shun: 3 articles (01/2014 - 11/2009)
10.	Greilberger, Joachim: 3 articles (02/2013 - 01/2011)

Related Diseases

1.	Dehydration (Water Stress) 10/25/2022 - "The hydroxymethylfurfural (HMF) contents remain within the permissible standard of <40 mg/kg. The total phenolic content increased after dehydration by these methods. " 12/14/2009 - "Studies on the HCl-catalysed microwave-assisted dehydration of highly concentrated aqueous fructose (27 wt%) to 5-hydroxymethylfurfural (HMF) revealed a significant increase in the fructose conversion rate over the conventional heated systems. " 03/01/2023 - "The first route finally generates 5-hydroxymethylfurfural through isomerization, dehydration, hydrolysis, elimination, and condensation, and the second route products dicarbonyl compounds through isomerization and elimination and then Strecker degradation forms aldehydes through condensation, decarboxylation, hydrolysis, and elimination. " 05/06/2022 - "5-hydroxymethylfurfural (HMF) is produced upon dehydration of C6 sugars in biorefineries. " 01/01/2022 - "5-Hydroxymethylfurfural (5-HMF) is a high value-added platform compound which can be obtained by dehydration of hexose under acidic conditions. "
2.	Neoplasms (Cancer) 01/01/2020 - "SIGNIFICANCE STATEMENT: 5-Hydroxymethyl-2-furfural (5HMF), a component of natural medicinal honeys, blocks the ion conductance but not the water flux through human Aquaporin-1 (AQP1) channels and impairs AQP1-dependent cell migration and invasiveness in cancer cell lines. " 04/01/2010 - "Alpha-ketoglutaric acid (alpha-KG) and 5-hydroxymethylfurfural (5-HMF) are currently under investigation as promising cancer cell damaging agents. " 01/09/2007 - "Hydroxymethylfurfural (HMF) and alpha-ketoglutaric acid (KG) have been recently investigated as potential cancer cell damaging agents. " 01/01/2013 - "Alpha-ketoglutaric acid (KG) and hydroxymethylfurfural (HMF) are currently being investigated in clinical trials as an approach in targeted cancer therapy. " 08/07/2023 - "The aim of this study was to investigate the potential of alpha-ketoglutarate (aKG), 5-hydroxymethylfurfural (5-HMF), and their combination as mitochondrial-targeting antioxidants in MTC-SK or NCI-H23 cancer cells. "
3.	Hypoxia (Hypoxemia) 02/23/2015 - "Enhanced hypoxia-inducible factor (HIF)-1α stability induced by 5-hydroxymethyl-2-furfural (5-HMF) contributes to protection against hypoxia." 01/01/2019 - "Cardiovascular Parameters in a Swine Model of Normobaric Hypoxia Treated With 5-Hydroxymethyl-2-Furfural (5-HMF)." 02/23/2015 - "We first reported the role of 5-hydroxymethyl-2-furfural (5-HMF) against hypoxia. " 09/01/2011 - "The protective role of 5-hydroxymethyl-2-furfural (5-HMF) against acute hypobaric hypoxia." 01/01/2023 - "5-Hydroxymethylfurfural reduces skeletal muscle superoxide production and modifies force production in rats exposed to hypobaric hypoxia."
4.	Inflammation (Inflammations) 08/30/2023 - "5-Hydroxymethylfurfural Ameliorates Allergic Inflammation in HMC-1 Cells by Inactivating NF-κB and MAPK Signaling Pathways." 01/13/2019 - "5-Hydroxymethylfurfural Mitigates Lipopolysaccharide-Stimulated Inflammation via Suppression of MAPK, NF-κB and mTOR Activation in RAW 264.7 Cells." 02/01/2023 - "5-Hydroxymethylfurfural induces mice frailty through cell senescence-associated sarcopenia caused by chronic inflammation."
5.	Diabetes Mellitus 04/01/1985 - "When the three methods were compared the overlap between normals and diabetics was found to be less, using the 5-hydroxymethylfurfural HPLC method, suggesting that this procedure, although more time consuming, seems to be more useful in the management of diabetes mellitus." 01/01/1988 - "As demonstrated by the finding of 5-hydroxymethylfurfuraldehyde augmentation, higher glucose concentrations result in elevated glycation of both blood cell membrane proteins and hemoglobin, followed by the increase of membrane diphenylhexatriene anisotropy, thus resembling by consequences the affection of blood proteins by chronic hyperglycaemia in diabetes mellitus."

Related Drugs and Biologics

1.	Fructose
2.	Glucose (Dextrose)
3.	Ketoglutaric Acids (Ketoglutaric Acid)
4.	Lewis Acids
5.	Selenomethionine (Sethotope)
6.	Methionine (L-Methionine)
7.	Acids
8.	Furaldehyde (Furfural)
9.	Zeolites
10.	Solvents

Related Therapies and Procedures

1.	Therapeutics
2.	Nanospheres
3.	Microspheres (Microsphere)
4.	Intraperitoneal Injections
5.	Fluid Therapy (Oral Rehydration Therapy)