|1.||Sugiura, Hisatoshi: 3 articles (05/2013 - 01/2012)|
|2.||Koarai, Akira: 3 articles (05/2013 - 01/2012)|
|3.||Akamatsu, Keiichiro: 3 articles (05/2013 - 01/2012)|
|4.||Minakata, Yoshiaki: 3 articles (05/2013 - 01/2012)|
|5.||Ichikawa, Tomohiro: 3 articles (05/2013 - 01/2012)|
|6.||Ichinose, Masakazu: 3 articles (05/2013 - 01/2012)|
|7.||Hirano, Tsunahiko: 3 articles (05/2013 - 01/2012)|
|8.||Matsunaga, Kazuto: 3 articles (05/2013 - 01/2012)|
|9.||Pezacki, John Paul: 2 articles (12/2015 - 01/2009)|
|10.||Rouleau, Yanouchka: 2 articles (12/2015 - 01/2009)|
|1.||Atherosclerotic Plaque (Atheroma)
02/01/2015 - "24S-hydroxycholesterol (24S-HC), 25-hydroxycholesterol (25-HC), and 27-hydroxycholesterol (27-HC) were assessed in plasma and arteries with atherosclerotic plaques from 10 patients (54-84 years) with severe peripheral artery disease (PAD) as well as arteries free of atherosclerotic plaques from 13 individuals (45-78 years, controls). "
09/15/2006 - "In the present study, we investigated the cytotoxic effects of 7beta-hydroxycholesterol (7betaOH), 7-ketocholesterol (7keto), 25-hydroxycholesterol (25OH), and 27-hydroxycholesterol (27OH) on U937 monocytic cells, both individually and in atheroma-relevant mixtures mimicking the oxysterol composition reported in human atheroma lesions. "
03/01/2007 - "As products of cholesterol oxidation (oxysterols) accumulate within atherosclerotic plaque and have been proposed to contribute to inflammatory signalling in the diseased artery, we investigated the potential of 7-ketocholesterol (7-KC), 7beta-hydroxycholesterol (7beta-HC) and 25-hydroxycholesterol (25-HC) to stimulate inflammatory signalling via the lipid-recognising TLRs 1, 2, 4 and 6. Each oxysterol stimulated secretion of the inflammatory chemokine interleukin-8 (IL-8), but not IkappaBalpha degradation or tumour necrosis factor-alpha release from monocytic THP-1 cells. "
09/01/1994 - "The objective of this study was to investigate the effects of oxysterols (OS), namely 5 alpha-hydroxy-6-ketocholestanol, 6-ketocholestanol and 25-hydroxycholesterol, on specific cell-mediated cytotoxicity by C57BL/6 spleen cells against P815-X2 (a DBA/2 mastocytoma) target cells. "
08/01/1984 - "The mechanism whereby 25-hydroxycholesterol, an inhibitor of the synthesis of cholesterol, depresses DNA synthesis in cycling P815 mastocytoma cells was investigated. "
|3.||Allergic Contact Dermatitis
|4.||Hepatocellular Carcinoma (Hepatoma)
04/01/2013 - "The titled compounds were evaluated for their potency to regulate sterol and triglyceride biosynthesis in human hepatoma Hep G2 cells in comparison with 25-hydroxycholesterol. "
06/07/2002 - "In transfected hepatoma cells, 25-hydroxycholesterol increased murine Cyp7a1 gene promoter activity, whereas the human CYP7A1 gene promoter was unresponsive. "
05/01/1995 - "Movement of 25-hydroxycholesterol from the plasma membrane to the rough endoplasmic reticulum in cultured hepatoma cells."
04/01/1991 - "Activation of the silent endogenous cholesterol-7-alpha-hydroxylase gene in rat hepatoma cells: a new complementation group having resistance to 25-hydroxycholesterol."
05/01/2000 - "Previously, we have demonstrated that treatment of rat AH136B ascites hepatoma cells with 25-hydroxycholesterol (25-OH) induces apoptosis. "
05/01/2000 - "These findings suggest that local combined treatment with 25-hydroxycholesterol and low-dose TNF can induce synergistic anti-tumor effects."
09/01/1998 - "Macrophage inhibition of lymphocyte and tumor cell growth is mediated by 25-hydroxycholesterol in the cell membrane."
03/01/1986 - "The kinetics of cell cycle progression in continuously proliferating 3T3 fibroblasts and two tumor transformed derivatives (3T6 and SV 3T3 cells) following treatment by growth-factor deprivation (serum starvation) or 25-hydroxycholesterol were studied. "
04/01/2004 - "To investigate whether oxysterols can regulate StAR expression, two steroidogenic cell lines, mouse Y1 adrenocortical and MA-10 Leydig tumor cells, were treated with various oxysterols and steroids, including 25-hydroxycholesterol (25 OHC), 22(R)OHC and 20alphaOHC. "
01/01/1991 - "25-Hydroxycholesterol and 20 alpha-hydroxycholesterol are potent suppressors of generation and proliferation of tumor-specific cytotoxic T lymphocytes. "
|2.||cholest-5-en-3 beta,7 alpha-diol
|7.||Interleukin-8 (Interleukin 8)
|8.||Messenger RNA (mRNA)
|10.||Cytochromes c (Cytochrome c)