homocysteine thiolactone

Also Known As:

Hcy-thiolactone; homocysteine thiolactone hydrochloride; homocysteine thiolactone hydrochloride, (+-)-isomer; homocysteine thiolactone perchlorate salt; homocysteine thiolactone perchlorate, (S)-isomer; homocysteine thiolactone, (+-)-isomer; homocysteine thiolactone, (S)-isomer; homocysteine thiolactone, DL; homocysteine-thiolactone; 3-aminodihydro-2(3H)-thiophenone

Networked: 166 relevant articles (2 outcomes, 17 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Jakubowski, Hieronim: 28 articles (10/2020 - 02/2005)
2.	Jakubowski, H: 8 articles (01/2021 - 02/2000)
3.	Djuric, Dragan: 7 articles (01/2018 - 01/2009)
4.	Głowacki, Rafał: 6 articles (07/2020 - 11/2010)
5.	Stanojlović, Olivera: 6 articles (01/2013 - 05/2009)
6.	Borowczyk, Kamila: 5 articles (11/2018 - 01/2012)
7.	Djuric, D: 5 articles (10/2016 - 05/2014)
8.	Hrncić, Dragan: 5 articles (01/2013 - 01/2009)
9.	Rasić-Marković, Aleksandra: 5 articles (01/2013 - 01/2009)
10.	Macut, Djuro: 4 articles (01/2012 - 05/2009)

Related Diseases

1.	Seizures (Absence Seizure) 06/01/2014 - "The aim of the study was to examine the effects of chronic exercise training on seizures induced by homocysteine thiolactone (HCT) in adult rats. " 01/01/2013 - "The aim of the present study was to investigate the effects of paradoxical sleep deprivation on homocysteine thiolactone (H)-induced seizures in rats, a model of generalized seizures. " 05/01/2009 - "Two types of seizures in homocysteine thiolactone-treated adult rats, behavioral and electroencephalographic study." 01/01/2014 - "The inactivation of the Pon1 gene in mice causes the accumulation of Hcy-thiolactone in the brain and increases the susceptibility to Hcy-thiolactone-induced seizures. " 01/01/2014 - "The inactivation of the Blmh gene in mice causes accumulation of Hcy-thiolactone in the brain and increases susceptibility to Hcy-thiolactone-induced seizures. "
2.	Myocardial Infarction 01/01/1988 - "Homocysteine thiolactone was isolated from normal human plasma, sera of patients with acute myocardial infarction, and human neoplastic tissue. " 01/01/2019 - "Urinary excretion of homocysteine thiolactone and the risk of acute myocardial infarction in coronary artery disease patients: the WENBIT trial." 05/01/1991 - "No homocysteine thiolactone could be found in serum samples from six patients with acute myocardial infarction, three patients with cystathionine beta-synthase deficiency, and six normal subjects. " 01/01/2019 - "Our objective was to examine Hcy-thiolactone, a chemically reactive metabolite generated by methionyl-tRNA synthetase and cleared by the kidney, as a risk predictor of incident acute myocardial infarction (AMI) in the Western Norway B-Vitamin Intervention Trial. "
3.	Atherosclerosis 01/01/2011 - "Recently it has been suggested that a physiological substrate of serum PON1 is homocysteine thiolactone which is a putative risk factor in atherosclerosis. " 01/01/2002 - "Prevention of homocysteine thiolactone induced atherogenesis in rats." 04/01/1999 - "Homocysteine thiolactone is a cyclic thioester that is implicated in the development of atherosclerosis. " 01/01/2006 - "This article reviews recent studies of Hcy-thiolactone and N-Hcy-protein in the human body, including their roles in autoimmune response, cellular toxicity, and atherosclerosis. " 08/01/2006 - "Paraoxonase-1 (PON1) detoxifies homocysteine thiolactone (HcyT) in human blood and could thus delay the development of atherosclerosis. "
4.	Hyperhomocysteinemia 01/01/2022 - "Hyperhomocysteinemia was induced by intragastric administration of DL-homocysteine thiolactone. " 05/21/2018 - "Taken together, these findings suggest that PON1 hydrolyzes Hcy-thiolactone in humans and that the interindividual variations in PON1 genotype/activity can modulate the pathology of hyperhomocysteinemia.-Perła-Kaján, J., Borowczyk, K., Głowacki, R., Nygård, O., Jakubowski, H. " 06/01/2015 - "The maximal cardiotoxic effect of homocysteine thiolactone was detected at 1 × 10⁻³ M, which corresponds to severe hyperhomocysteinemia. " 07/01/2012 - "Hyperhomocysteinemia was induced using a reduced form of Hcys (at final dose of 0.1mM) and the most reactive form of Hcys - its cyclic thioester, homocysteine thiolactone (HTL, 1 μM). " 01/01/2011 - "We induced hyperhomocysteinemia using a reduced form of Hcys (final dose, 0.1 mM) and the most reactive form of Hcys, its cyclic thioester, homocysteine thiolactone (HTL, 1 µM). "
5.	Neoplasms (Cancer) 05/18/2008 - "In 1993, Jakubowski found that cancer cells (but not normal cells) contain measurable quantities of homocysteine thiolactone. " 11/21/2003 - "Therefore, we studied the effects of homocysteine thiolactone on different key steps of angiogenesis and tumor invasion, using model endothelial and tumor cell lines. " 11/21/2003 - "An in vitro evaluation of the effects of homocysteine thiolactone on key steps of angiogenesis and tumor invasion." 06/01/1995 - "Toxicity, biodistribution and radioprotective capacity of L-homocysteine thiolactone in CNS tissues and tumors in rodents: comparison with prior results with phosphorothioates." 01/01/1988 - "The amount of homocysteine thiolactone in three human neoplasms was 17-123 mumol/kg. Only trace amounts were found in normal tissues, and none was detected in two other human neoplasms. "

Related Drugs and Biologics

1.	Methionine-tRNA Ligase
2.	Vitamin B Complex (B Vitamins)
3.	Adenosine (Adenocard)
4.	Anticonvulsants (Antiepileptic Drugs)
5.	Homocysteine
6.	Folic Acid (Vitamin M)
7.	Proteins (Proteins, Gene)
8.	Arginine (L-Arginine)
9.	Methionine (L-Methionine)
10.	Glycosaminoglycans

Related Therapies and Procedures

1.	Intraperitoneal Injections
2.	Enzyme Therapy
3.	Therapeutics
4.	Microspheres (Microsphere)
5.	Injections