octogen (HMX)

an explosive compound, contaminant in waste water; structure given in third source

Also Known As:

HMX; cyclotetramethylenetetranitramine; 1,3,5,7-tetranitro-1,3,5,7-tetraazacyclooctane; beta-1,3,5,7-tetranitro-1,3,5,7-tetraazacyclooctane; cyclotetramethylene-tetranitramine; octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine

Networked: 34 relevant articles (0 outcomes, 6 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azocines
    - octogen: 34

Experts

1.	Ji, Guang-Fu: 5 articles (04/2022 - 11/2012)
2.	Huang, Fenglei: 3 articles (05/2019 - 07/2014)
3.	Chen, Xiang-Rong: 3 articles (07/2014 - 11/2012)
4.	Ge, Ni-Na: 3 articles (07/2014 - 11/2012)
5.	Wei, Yong-Kai: 3 articles (07/2014 - 11/2012)
6.	Zhao, Feng: 3 articles (07/2014 - 11/2012)
7.	Chen, Jun: 2 articles (04/2022 - 08/2015)
8.	He, Zheng-Hua: 2 articles (04/2022 - 08/2015)
9.	Wu, Qiang: 2 articles (04/2022 - 08/2015)
10.	Song, Huajie: 2 articles (07/2016 - 07/2014)

Related Diseases

1.	Shock 04/27/2022 - "Anisotropic Reaction Properties for Different HMX/HTPB Composites: A Theoretical Study of Shock Decomposition." 03/28/2015 - "Anisotropic shock sensitivity in a single crystal δ-cyclotetramethylene tetranitramine: a reactive molecular dynamics study." 07/24/2014 - "Molecular dynamics simulations in conjunction with multiscale shock technique (MSST) are performed to study the initial chemical processes and the anisotropy of shock sensitivity of the condensed-phase HMX under shock loadings applied along the a, b, and c lattice vectors. " 10/31/2022 - "Overall, the compression behaviors of HMX under uniaxial compressions would provide a useful insight for the actual shock compression conditions." 04/27/2022 - "Here, we construct three composites of β-HMX bonded with the HTPB binder to investigate the reaction characteristics under shock loading using the quantum-based molecular dynamics method. "
2.	Neoplasms (Cancer) 04/01/2020 - "We classified HM1 and HMX into type A, in which cancer was exposed on the HM, and type B, in which the HM status was unclear because of mechanical or thermal damage. " 11/01/2016 - "Outcomes included the number of instances of thermal denaturation of the horizontal/vertical margin (HMX/VMX) or positive horizontal/vertical margins (HM+/VM+), the shortest distance from tumor margins to resected edges, and the maximum bulge distances from tumor surface to the muscularis propria. " 11/01/2011 - "Endoscopic mucosal resection (EMR) was performed, and the resected tumor was pap, m, ly0, v0, HMX, VM0, pathologically. " 04/01/2020 - "We further classified type B according to the distance between the cancer and the edge of the specimen: type B1, <1 mm and type B2, ≥1 mm. The resection margin was judged as HM1 or HMX in 5.0% (39/767; 95% confidence interval, 3.5-6.6%) of the en bloc resected specimens. "
3.	Ectromelia (Phocomelia) 01/01/1987 - "Polydactylous outgrowth, an expression of the Hemimelia-extra toe (Hmx/+) mutant phenotype, was experimentally regulated in hindlimb buds explanted into a serum-free in vitro system at stage 18 of gestation. " 10/01/1981 - "A dominant mutation in the mouse, Hemimelia-extra toe (Hmx), induces congenital limb malformations in heterozygotes. " 10/01/1981 - "The role of morphogenetic cell death during abnormal limb-bud outgrowth in mice heterozygous for the dominant mutation Hemimelia-extra toe (Hmx)." 02/01/1985 - "The induction of polydactyly in mouse embryos heterozygous for Hemimelia-extra toe (Hmx) is associated with aberrant outgrowth of the developing autopod on day 12 of gestation. " 02/01/1985 - "Elevated rate of DNA synthesis and its correlation to cAMP-phosphodiesterase activity during induction of polydactyly in mouse embryos heterozygous for Hemimelia-extra toe (Hmx)."
4.	Body Weight (Weight, Body) 03/01/2012 - "Although there was a suggestion of an HMX-induced reduction in body weight in adult females, overall there were no effects observed over the 12 week exposure period. " 08/01/2011 - "Animals were divided into five groups viz., control group, 3-HMX (40 mg/kg of body weight) treated group, diabetic group, diabetic+3-HMX (40 mg/kg of body weight), and diabetic+glibenclamide (600 μg/kg of body weight). " 08/13/2005 - "Initially, 8 birds (1 male/1 female per dose group) were orally dosed at levels ranging from 125 to 2125 mg HMX/kg body weight. "
5.	Rupture 09/15/2020 - "Active nano-AlH3 causes HMX to decompose rapidly at low temperature, and the primary decomposition pathway is the rupture of N-O and C-N bonds. " 01/01/2016 - "Obtained results suggest that HMX hydrolysis at pH 10 represents a highly exothermic multistep process involving initial deprotonation and nitrite elimination, hydroxide attachment accompanied by cycle cleavage, and further decomposition of cycle-opened intermediate to the products caused by a series of C-N bond ruptures, hydroxide attachments, and proton transfers. "

Related Drugs and Biologics

1.	octogen (HMX)
2.	Trinitrotoluene (TNT)
3.	cyclonite (RDX)
4.	Explosive Agents (Explosives)
5.	3',5'-Cyclic-AMP Phosphodiesterases (3',5' Cyclic Nucleotide Phosphodiesterase)
6.	Protons (Proton)
7.	Plastics
8.	Pentaerythritol Tetranitrate (Pentalog)
9.	Nitrites
10.	Methamphetamine (Desoxyn)