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heliomycin

Russian drug; antibiotic with antiviral properties isolated from Actinomyces flavochromogenes var. heliomycini; structure

Also Known As:

geliomitsin

Networked: 5 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Polycyclic Compounds: 6
- heliomycin: 5

Experts

1.	Chueh, Pin Ju: 2 articles (01/2022 - 01/2018)
2.	Shchekotikhin, Andrey E: 2 articles (01/2022 - 01/2018)
3.	Tikhomirov, Alexander S: 2 articles (01/2022 - 01/2018)
4.	Islam, Atikul: 1 article (01/2022)
5.	Liang, Ru-Hao: 1 article (01/2022)
6.	Lin, Ming Hung: 1 article (01/2022)
7.	Liu, Yen-Hui: 1 article (01/2022)
8.	Weng, Chia-Wei: 1 article (01/2022)
9.	Zhan, Jun-Han: 1 article (01/2022)
10.	Abdalla, Mohga S: 1 article (01/2021)

Related Diseases

1.	Infections 05/01/1989 - "Efficacy of heliomycin was detected in hamsters with experimental bacteroide infection in the buccal sac. "
2.	Hepatocellular Carcinoma (Hepatoma) 01/01/2021 - "To the best of our knowledge, this is the first study to report the anticancer activity of heliomycin against hepatocellular carcinoma in vivo." 01/01/2021 - "Inhibitory and ameliorative effect of heliomycin derived from actinomycete on induced hepatocellular carcinoma in rats."
3.	Urinary Bladder Neoplasms (Bladder Cancer) 01/01/2022 - "Taken together, these findings clearly show that SIRT1 is targeted and downregulated by heliomycin and its water-soluble 4-aminomethylated derivative (HD2) possibly through autophagic and/or proteasomal degradation, leading to cell death and growth suppression of T24 bladder cancer cells." 01/01/2022 - "In this present study, we used the cellular thermal shift assay (CETSA) in T24 bladder cancer cells to show that heliomycin (designated compound (H1)) and its 4-(tert-butylamino)methyl derivative (HD2) directly engaged with SIRT1 in the native cellular environment, whereas another derivative (HD3) did not. " 01/01/2022 - "Antibiotic heliomycin and its water-soluble 4-aminomethylated derivative provoke cell death in T24 bladder cancer cells by targeting sirtuin 1 (SIRT1)."
4.	Skin Diseases (Skin Disease) 02/01/1963 - "[On the treatment of patients with various skin diseases with 1 per cent heliomycin ointment]."
5.	Neoplasms (Cancer) 01/01/2018 - "Testing the antiproliferative efficacy revealed a potent activity of heliomycin as well as its new derivatives on a panel of mammalian tumor cells including drug resistant variants. "

Related Drugs and Biologics

1.	Sirtuin 1
2.	N-glycolylneuraminyllactosylceramide (HD3)
3.	Ointments (Pastes)
4.	Diethylnitrosamine (N-Nitrosodiethylamine)
5.	Anti-Bacterial Agents (Antibiotics)