hecogenin

steroidal sapogenin which has been isolated from plants particularly from numerous Agave species; used in prep of steroidal hormones; structure; RN given refers to (3beta,5alpha,25R)-isomer

Also Known As:

hecogenin, (3beta,5alpha,25S)-isomer; (22R,25R)-3 beta-hydroxy-5 alpha-spirostan-12-one

Networked: 19 relevant articles (1 outcomes, 6 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Terpenes: 1461
    - Triterpenes: 2493
      - Sapogenins: 26
        hecogenin: 19
Polycyclic Compounds: 6
- Fused-Ring Compounds
  - Steroids: 70059
    - Sapogenins: 26
      - hecogenin: 19

Experts

1.	Ingawale, Deepa K: 3 articles (04/2021 - 02/2018)
2.	Patel, Snehal S: 3 articles (04/2021 - 02/2018)
3.	Beneytout, Jean-Louis: 3 articles (10/2007 - 04/2003)
4.	Liagre, Bertrand: 3 articles (10/2007 - 04/2003)
5.	Mandlik, Satish K: 2 articles (04/2021 - 04/2019)
6.	Bai, Chengfeng: 1 article (01/2021)
7.	Chen, Ligang: 1 article (01/2021)
8.	Chen, Xiangzhou: 1 article (01/2021)
9.	Luo, Guoshun: 1 article (01/2021)
10.	Luo, Xiaobin: 1 article (01/2021)

Related Diseases

1.	Edema (Dropsy) 02/01/2018 - "Treatment of rats with hecogenin and its combination elicited significant reduction in paw edema, arthritic score and joint diameter. "
2.	Neoplasms (Cancer) 04/01/2019 - "Objective: Hecogenin is a sapogenin found in Agave sisalana species that is used extensively for the treatment of anti-inflammatory, antifungal, hypotensive, anti-nociceptive activity and cancer. " 01/01/2021 - "Hecogenin, a steroidal sapogenin, is reported as a potential anti-tumor agent against breast cancer. " 06/26/2023 - "Finally, our study has suggested that Hecogenin and Glabrene can be potential S6K1 inhibitors which are presumably implicated in the therapeutic management of associated diseases such as diabetes, obesity, and varying types of cancer.Communicated" 12/15/2017 - "Rationally designed hecogenin thiosemicarbazone analogs as novel MEK inhibitors for the control of breast malignancies."
3.	Genomic Instability 01/01/2016 - "Further studies need to be performed to confirm the observed protective effect of Hecogenin against genomic instability."
4.	Stomach Ulcer (Gastric Ulcer) 05/15/2012 - "Effects of hecogenin and its possible mechanism of action on experimental models of gastric ulcer in mice." 05/15/2012 - "This study investigates the gastroprotective effects of hecogenin, a steroid saponin isolated from Agave sisalana, on experimental models of gastric ulcer. "
5.	Obesity 06/26/2023 - "Finally, our study has suggested that Hecogenin and Glabrene can be potential S6K1 inhibitors which are presumably implicated in the therapeutic management of associated diseases such as diabetes, obesity, and varying types of cancer.Communicated"

Related Drugs and Biologics

1.	Saponins
2.	Triterpenes
3.	Steroids
4.	Sulfonic Acids
5.	Galactose (Galactopyranose)
6.	Freund's Adjuvant
7.	glabrene
8.	sarsasapogenin
9.	Diosgenin
10.	Cytokines

Related Therapies and Procedures

1.	Therapeutics
2.	Aftercare (After-Treatment)
3.	Intranasal Administration