HCE

analog of dieldrin; RN given refers to cpd without isomeric designation; structure

Also Known As:

HCE, (1aalpha,3aalpha,4alpha,7alpha,7aalpha)-isomer; HCE, (1aalpha,3aalpha,4beta,7beta,7aalpha,7balpha)-isomer; 1,2,3,4,9,9-hexachloro-exo-5,6-epoxy-1,4,4a,5,6, 7,8,8a-octahydro-1,4-methanonaphthalene

Networked: 244 relevant articles (19 outcomes, 43 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Halogenated Hydrocarbons: 42
    - Chlorinated Hydrocarbons: 240
      - Dieldrin: 281
        HCE: 244

Experts

1.	Shukla, Deepak: 6 articles (12/2022 - 11/2010)
2.	Kong, Hyun-Hee: 6 articles (04/2022 - 12/2015)
3.	Moon, Eun-Kyung: 6 articles (04/2022 - 12/2015)
4.	Yadavalli, Tejabhiram: 5 articles (12/2022 - 01/2017)
5.	Quan, Fu-Shi: 5 articles (04/2022 - 02/2020)
6.	Nishida, Teruo: 5 articles (05/2011 - 01/2008)
7.	Kim, Min-Jeong: 4 articles (04/2022 - 01/2021)
8.	Lee, Hae-Ahm: 4 articles (02/2022 - 02/2020)
9.	Wen, Hao: 4 articles (08/2021 - 12/2010)
10.	Nagai, Noriaki: 4 articles (01/2021 - 01/2011)

Related Diseases

1.	Dry Eye Syndromes (Dry Eye Syndrome) 08/01/2020 - "The aim of the present study was to analyze the therapeutic efficacy of EJ in DED using human corneal epithelial (HCE) cells and a mouse model of experimental dry eye (EDE). " 01/01/2017 - "The aim of this study was to assess the efficacy of a new ocular surface modulator in an in vitro model of human corneal epithelium (HCE) damaged by severe osmotic stress mirroring the features of dry eye conditions. " 01/12/2011 - "The present study was concerned with the development of a new experimental model of dry eye using human reconstructed in vitro corneal epithelium (HCE). " 01/01/2018 - "Ocular tissues, conjunctival (HCjE) and human corneal (HCE) epithelial cell lines as well as tearfilm of patients suffering from different forms of dry eye disease (DED) were analyzed by means of RT-PCR, western blot, immunohistochemistry, and ELISA. " 01/12/2011 - "The HCE model was maintained in a controlled environmental setting (relative humidity <40% and 40 °C temperature) for 24 h and up to 72 h to induce dry eye. "
2.	Inflammation (Inflammations) 01/01/2021 - "Reconstructed HCE could be used as an in vitro model to study the effects of environmental PM exposure on ocular surface cell viability and inflammation." 01/01/2015 - "The HCE tissue culture may be used as an in vitro model to study environmental exposure induced eye irritation and inflammation." 01/01/2020 - "MiR-205-3p inhibited inflammation and oxidative stress in HCE cells induced by UV radiation (p < 0.01). " 01/01/2018 - "Taken together, the data suggests that HCE-T cells under desiccation stress showed NFκB mediated inflammation, which was rescued through the anti-inflammatory effect of CQ without altering the autophagy flux. " 04/01/2008 - "Taken together with results from HCE cells, these findings demonstrate that JNK has an essential role in TLR2-induced corneal inflammation."
3.	Wounds and Injuries (Trauma) 01/01/2019 - "This study indicates that HCE could be an effective agent for wound healing in diabetic wound model via its ability to suppress the MMP-9 gene expression and regulates MMP-1 gene expression besides its antioxidative, anti-inflammatory effects." 04/01/2012 - "For the in vitro studies, linear scratch wounds were made on cultured SV40-immortalized human corneal epithelial cells (HCE-T). " 01/13/2023 - "A DED wound healing model was developed by analyzing the influence of coating and serum concentrations on human corneal epithelial (HCE-T) wound closure. " 09/01/2021 - "HCE were cultured and injured (corneal in vitro wound model) and then stimulated with S.Ctrl or S. " 04/22/2020 - "In conclusion, the direct comparison of both basic wound models demonstrated that the healing was significantly increased following HCE, thus this extract may be found useful to improve healing of acute wounds. "
4.	Corneal Injuries 01/27/2021 - "The MPCP viscosity (approximately 0.95 mPa·s) was 1.17-fold that of purified water, and a decrease in the transepithelial electrical resistance value (corneal damage) was not observed in the immortalized human corneal epithelial cell line HCE-T cell (HCE-T cell layer). " 07/01/2015 - "HCE cells treated with AMX healed faster after mechanical insult, suggesting a potential benefit in acute corneal injuries. " 01/01/2017 - "We report for the first time that HA can protect HCE cells against the toxicity of Cr(VI), indicating that it will be a promising therapeutic agent to corneal injuries caused by Cr(VI)." 11/01/2014 - "HCE-T cells were significantly more viable at pH 7 than at pH 1-6. To avoid corneal damage, preoperative antisepsis of the surgical field should be accomplished with PAI diluted 6-fold, rather than with PVP-I diluted 16-fold. " 01/01/2012 - "These results clarified that FAD inhibits ROS-mediated apoptosis by UV-B irradiation in HCE-T cells and suggest that FAD may be effective as a radical scavenger in UV-B-induced corneal damage."
5.	Neoplasms (Cancer) 10/01/2012 - "HCE in periampullary cancer is safe and effective in selected patients. " 02/01/2013 - "This study was designed to examine the in vitro antiproliferative effect of the horse chestnut extract (HCE) on cancer cell lines. " 01/01/2023 - "The model examined multiple scenarios accounting for cancer-related healthcare expenditure (HCE) only, cancer-related and unrelated background HCE, adding productivity benefits (i.e., patient time, cancer-related productivity loss, and background labor and nonlabor market production), and with nonhealth consumption costs, adjusted for household economies of scale. " 12/01/2022 - "Our results indicate that among decedents in particular, the expenditures for treatment of neoplasms have exceeded the general trend in HCE. " 06/01/2022 - "Malignancy was associated with increased risk of HCE and RLN injury. "

Related Drugs and Biologics

1.	Timolol (Blocadren)
2.	Ophthalmic Solutions (Eye Drops)
3.	Benzalkonium Compounds (Benzalkonium Chloride)
4.	Interleukins
5.	Collagen
6.	Simvastatin (Zocor)
7.	Etoposide (VP 16)
8.	Cytarabine (Cytosar-U)
9.	Phytosomes
10.	Proteins (Proteins, Gene)

Related Therapies and Procedures

1.	Cystectomy
2.	Therapeutics
3.	Contact Lenses
4.	Palliative Care (Palliative Therapy)
5.	Ligation