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N- methylamino- 2- nitro- 4- N',N'- bis(2- hydroxyethyl)aminobenzene
structure
Also Known As:
HC Blue No. 1; 2,2'-((4-(methylamino)-3-nitrophenyl)imino)bisethanol
Networked:
4
relevant articles (
0
outcomes,
2
trials/studies)
Bio-Agent Context: Research Results
Organic Chemicals: 133
Amines: 4871
Polyamines: 3918
Diamines: 518
Phenylenediamines: 6
N-methylamino-2-nitro-4-N',N'-bis(2-hydroxyethyl)aminobenzene: 4
Aniline Compounds: 46
Phenylenediamines: 6
N-methylamino-2-nitro-4-N',N'-bis(2-hydroxyethyl)aminobenzene: 4
Related Diseases
1.
Carcinogenesis
08/01/1985 - "
An audit of the experimental data was conducted for these carcinogenesis studies on HC Blue No. 1. No data discrepancies were found that influenced the final interpretations.
"
08/01/1985 - "
NTP Toxicology and Carcinogenesis Studies of HC Blue No. 1 (CAS No. 2784-94-3) in F344/N Rats and B6C3F1 Mice (Feed Studies).
"
08/01/1985 - "
Toxicology and carcinogenesis studies of HC Blue No. 1 (97% pure), a semipermanent hair dye, were conducted by administering the test chemical in feed for 103 weeks to groups of 50 F344/N rats and 50 B6C3F1 mice of each sex.
"
06/01/1989 - "
Toxicology and carcinogenesis studies of 2 structurally-related p-phenylenediamines, HC Blue No. 1, and HC Blue No. 2 were conducted by administering each chemical in feed for 103 weeks to both sexes of Fischer 344/N rats and B6C3F1 (C57BL/6N x C3H/HEN) mice.
"
2.
Carcinoma (Carcinomatosis)
08/01/1985 - "
Under the conditions of these feed studies, there was equivocal evidence of carcinogenicity in male F344/N rats, since HC Blue No. 1 caused a marginal increase in the incidence of hepatocellular neoplastic nodules/carcinomas.
"
08/01/1985 - "
Administration of HC Blue No. 1 produced significant positive trends in the incidences of male rats with hepatocellular neoplastic nodules/carcinomas (neoplastic nodules: control, 0/49; low dose, 0/50; high dose, 3/50; neoplastic nodules/carcinomas: 1/49; 0/50; 6/50).
"
08/01/1985 - "
HC Blue No. 1 produced dose-related increases in the incidences of proliferative lesions of the lungs (adenomatous hyperplasia and alveolar/bronchiolar adenomas or carcinomas) in female rats (hyperplasia: 2/50; 5/49; 8/50; adenoma/carcinoma: 1/50; 3/49; 7/50).
"
3.
Lymphoma (Lymphomas)
06/01/1990 - "
Mutagenicity evaluation of HC Blue No. 1 and HC Blue No. 2. III. Effects in the Salmonella typhimurium/Escherichia coli reversion assay and the mouse lymphoma L5178Y TK+/- forward mutation assay.
"
08/01/1985 - "
HC Blue No. 1 was mutagenic in the absence of activation in the L5178Y/TK+/- mouse lymphoma assay and induced unscheduled DNA synthesis in rat hepatocytes in vitro.
"
4.
Chromosome Breakage
06/01/1990 - "
Two hair-dye chemicals, HC Blue No. 1 and HC Blue No. 2, were assessed for the ability to produce chromosome breakage and/or spindle malformation in vivo by evaluating the capacity of these compounds to induce micronuclei in polychromatic erythrocytes of mouse bone marrow.
"
5.
Liver Cell Adenoma (Hepatocellular Adenoma)
08/01/1985 - "
In male and female mice, both doses of HC Blue No. 1 increased the incidences of hepatocellular carcinoma (male: 11/50; 20/50; 30/50; female: 1/50; 24/48; 47/49) and the low doses increased the incidences of hepatocellular adenomas (male: 4/50; 17/50; 10/50; female: 2/50; 11/48; 4/49).
"
Related Drugs and Biologics
1.
HC Blue No. 2
2.
Hair Dyes
3.
Phenylenediamines
4.
DNA (Deoxyribonucleic Acid)
5.
Ethanol (Ethyl Alcohol)