genipin

01/01/2022 - "An adequate and sustained delivery strategy of genipin at lower concentrations will be needed to achieve a safe and effective scleral crosslinking treatment for myopia control in tree shrews. "
01/01/2022 - "Scleral crosslinking using genipin has been identified as a promising treatment approach for myopia control. "
01/01/2022 - "The efficacy of genipin to alter biomechanical properties of the sclera has been shown in several animal models of myopia but its safety profile remains unclear. "
01/01/2021 - "The results of this preclinical study suggest that scleral crosslinking using genipin can slow myopia progression."
07/29/2015 - "Thus, the present study was designed to evaluate the effects of scleral cross-linking using genipin on the form-deprivation (FD) myopia process of guinea pigs. "

11/01/2019 - "In the present study, we aimed to determine whether the PI3K/AKT pathway is involved in the protective effects of genipin against mitochondrial-dependent apoptosis, endoplasmic reticulum stress (ERS), and inflammation in ALI. "
07/01/2019 - "These protective effects induced by genipin were reversed by 3-MA treatment, indicating that autophagy was involved in the protective effects exerted by genipin against inflammation and apoptosis in ALI. "
10/15/2014 - "In this study, we examined the effects of genipin on LPS-induced inflammation in BV-2 cells and sickness behavior in mice. "
06/01/2011 - "In this study, we investigated whether genipin inhibits expression of cellular adhesion molecules, which is relevant to inflammation. "
01/01/2023 - "Genipin is derived from gardenia fruit, which is a traditional Chinese medicinal herb for anti-inflammation. "

07/01/2019 - "3-MA prevented the protective effects of genipin against mitochondrial dysfunction and cell death. "
07/27/2019 - "Genipin induced apoptosis by suppressing the Stat3/Mcl-1 pathway and led to mitochondrial dysfunction. "
12/01/2013 - "In conclusion, genipin ameliorates age-related insulin resistance through inhibiting hepatic oxidative stress and mitochondrial dysfunction. "
12/01/2013 - "Genipin ameliorates age-related insulin resistance through inhibiting hepatic oxidative stress and mitochondrial dysfunction."
07/27/2019 - "Genipin induces mitochondrial dysfunction and apoptosis via downregulation of Stat3/mcl-1 pathway in gastric cancer."

01/01/2017 - "Genipin may have therapeutic potential for organ injuries including liver."
02/15/2014 - "Genipin was applied to stabilize the structure of the scaffolds and those crosslinked at a level of 7.3% exhibited a homogenous porous structure (33.1%), high swelling capacity (27.6g/g for wound exudate like medium; 62.5 g/g for water), and were stable under cyclic compression. "
12/01/2010 - "These results suggested that genipin-crosslinked SF/HBC nanofibrous scaffolds might be potential candidates for wound dressing and tissue-engineering scaffolds."
01/01/2006 - "Genipin suppressed wound-induced cell migration and proliferation. "
01/01/2017 - "Genipin is a component of Japanese traditional herbal medicine (Kampo), inchinkoto, and is used for the treatment of various liver injuries. "

07/01/2019 - "Although the protective effects of genipin against acute lung injury (ALI) have been described previously, the associated mechanism remains unclear. "
09/01/2016 - "This study aimed to evaluate the effect of genipin on murine model of acute lung injury induced by LPS. "
09/01/2016 - "Genipin alleviates LPS-induced acute lung injury by inhibiting NF-κB and NLRP3 signaling pathways."
11/01/2019 - "Genipin attenuates mitochondrial-dependent apoptosis, endoplasmic reticulum stress, and inflammation via the PI3K/AKT pathway in acute lung injury."
11/01/2019 - "The protective effects of genipin against lipopolysaccharide (LPS)-induced acute lung injury (ALI) have been reported; however, the mechanism is unclear. "