|1.||Lampe, Johanna W: 10 articles (09/2013 - 07/2003)|
|2.||Akaza, Hideyuki: 8 articles (01/2014 - 08/2002)|
|3.||Mori, Mitsuru: 8 articles (01/2014 - 08/2002)|
|4.||Adlercreutz, Herman: 8 articles (09/2012 - 04/2003)|
|5.||Tsukamoto, Taiji: 6 articles (01/2014 - 08/2002)|
|6.||Wähälä, Kristiina: 6 articles (01/2011 - 04/2003)|
|7.||Atkinson, Charlotte: 6 articles (03/2008 - 07/2003)|
|8.||Helferich, William G: 5 articles (04/2015 - 09/2004)|
|9.||Ueno, Tomomi: 5 articles (01/2015 - 05/2011)|
|10.||Ishimi, Yoshiko: 5 articles (09/2012 - 10/2004)|
07/01/2010 - "In the confirmation study, menopausal women who were equol nonproducers who consumed 10 mg/d of natural S-equol for 12 wk had significantly reduced severity and frequency of hot flashes as well as a significant reduction in the severity of neck or shoulder stiffness. "
03/01/2015 - "Clinical trials that evaluated the efficacy of an S-equol-containing product found that VMS were alleviated but these trials were limited in scope and primarily involved Japanese women for whom hot flashes are a minor complaint. "
03/01/2015 - "The only trial in the United States evaluating hot flashes found symptoms were significantly reduced by S-equol, but the study lacked a placebo group, although it did include a positive control. "
07/01/2010 - "Research opportunities now exist to determine whether equol's apparent effects on menopausal symptoms (hot flashes, sleep disturbances, bone health) in equol producers can be extended to equol nonproducers. "
09/01/2013 - "We randomized 130 perimenopausal (no menses in the past 3 mo) and postmenopausal (≥12 mo of amenorrhea) women with a mean of five or more moderate/severe hot flashes per day to treatment arms with varying total daily isoflavone doses and dosing frequency, separately for equol producers and nonproducers. "
03/01/2004 - "Only one third to one half of individuals produce equol, and evidence exists to support potential cancer-protective effects of equol production. "
03/06/2015 - "This study therefore implicates c-Myc as a potential regulator of the cancer-promoting effects of equol via up-regulation of eIF4GI and selective initiation of translation on mRNAs that utilize non-canonical initiation, including certain oncogenes. "
09/01/2014 - "The present study aimed to investigate anticancer properties of equol and demonstrate its underlying mechanisms of action in human cervical cancer HeLa cells. "
07/01/2014 - "In the present study, we use the SMMC-7721 cancer cell line to investigate the mechanisms of (±)-equol-induced, R-(+)-equol-induced, and S-(-)-equol-induced apoptosis. "
07/01/2010 - "Mechanisms of action of equol described using in vitro studies suggest possible effects of this compound in relation to cancer risk. "
|3.||Prostatic Neoplasms (Prostate Cancer)
02/01/2011 - "Although some observational and intervention studies suggest that the ability to produce equol is associated with reduced risk of breast and prostate cancer, CVD, improved bone health and reduced incidence of hot flushes, others have reported null or adverse effects. "
01/01/2014 - "This study found that counts of Slackia sp. strain NATTS correlated with serum concentrations of equol both in prostate cancer cases and controls, but serum isoflavone concentrations were not associated with risk of prostate cancer in our patients."
01/01/2012 - "To examine the prostate cancer risk based on isoflavone intake and equol production, we carried out a phase II, randomized, double-blind, placebo-controlled trial of oral isoflavone (60 mg/day) for 12 months. "
11/01/2010 - "Some studies on high soy-consuming populations reported an inverse association between urinary and serum equol concentrations and breast and prostate cancer risk. "
07/01/2010 - "Several studies in Asian men report lower equol concentrations or a lower prevalence of equol-producers among men with prostate cancer compared with controls, whereas studies in European populations report no association. "
|4.||Breast Neoplasms (Breast Cancer)
10/01/2012 - "The potential protective effects of equol in breast cancer are still under debate. "
01/15/2009 - "This study investigated the role of the caspase activation cascade in extrinsic and intrinsic apoptosis induced by equol in human breast cancer MDA-MB cells. "
03/01/2005 - "These results are consistent with studies that found lower urine 2:16OHE(1) ratios in women with breast cancer and suggest that soy consumption increases this ratio only in women who are equol producers."
02/01/2014 - "S-(-)equol producing status not associated with breast cancer risk among low isoflavone-consuming US postmenopausal women undergoing a physician-recommended breast biopsy."
01/01/2014 - "To investigate the proliferation inhibition effects of equol on human breast cancer cell line MCF-7 and explore its molecular mechanisms. "
|5.||Weight Loss (Weight Reduction)
11/01/2015 - "Recommend with caution: Some therapies that may be beneficial for alleviating VMS are weight loss, mindfulness-based stress reduction, the S-equol derivatives of soy isoflavones, and stellate ganglion block, but additional studies of these therapies are warranted. "
01/01/2011 - "Equol severely perpetrated dextran sulfate sodium (DSS)-induced colitis as evaluated by the weight loss. "
|2.||Biological Markers (Surrogate Marker)
|4.||Heterologous Transplantation (Xenotransplantation)