elymoclavine

ergot alkaloid isolated from cultures of fungi parasitic on Elymis mollis Trin; toxic alkaloid produced by Claviceps purpurea; structure

Also Known As:

elymoclavine hydrochloride; elymoklavine; 8,9-didehydro-6-methylergoline-8-methanol

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

1.	Seizures (Absence Seizure) 01/01/1984 - "Elymoclavine inhibited the picroroxin and electroshock convulsive seizures but potentiated the pentylenetetrazol ones in mice as these effects were differently influenced by pimozide, haloperidol, 5-HT, atropine and phentolamine. " 01/01/1984 - "Elymoclavine inhibited the picrotoxin and electroshock convulsive seizures but potentiated the pentylenetetrazol ones in mice as these effects were differently influenced by pimozide, haloperidol, 5-HTP, atropine and phentolamine. "
2.	Catalepsy 01/01/1984 - "II showed the following: LD50 for mice for 24 hours was 350 (228 divided by 535) mg/kg and for rats--145 (81 divided by 258) mg/kg; elymoclavine induced a dose-dependent stereotypy in rats and mice which was antagonized by haloperidol and pimozide; it prevented the development of haloperidol catalepsy in rats and produced rotations contralateral to the striatal lesions with 6-OHDA which were antagonized by pimozide and partly by cyproheptadine. "

1.	Pimozide (Orap)
2.	Phentolamine (Z-Max)
3.	Pentylenetetrazole (Metrazol)
4.	Haloperidol (Haldol)
5.	Atropine
6.	Oxidopamine (6 Hydroxydopamine)
7.	Serotonin (5 Hydroxytryptamine)
8.	Picrotoxin
9.	5-Hydroxytryptophan (5 Hydroxytryptophan)
10.	Cyproheptadine (Periactin)