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2,4-dithiobiuret

structure

Networked: 7 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amides: 2428
  - Urea: 15015
    - Thiourea: 362
      - 2,4-dithiobiuret: 7
- Sulfur Compounds: 278
  - Thiourea: 362
    - 2,4-dithiobiuret: 7

Experts

1.	Bushnell, Philip J: 1 article (01/2004)
2.	Gadrinab, Louis G: 1 article (01/2004)
3.	Samsam, Tracey E: 1 article (01/2004)
4.	Atchison, William D: 1 article (12/2002)
5.	Autio, Dawn: 1 article (12/2002)
6.	Rheuben, Mary B: 1 article (12/2002)
7.	Xu, You-Fen: 1 article (12/2002)

Related Diseases

1.	Muscle Weakness 04/01/1991 - "2,4-Dithiobiuret (DTB) exposure causes a delayed onset muscle weakness in rats that has been attributed to depressed neuromuscular transmission. " 12/01/2002 - "Chronic treatment of rodents with 2,4-dithiobiuret (DTB) induces a neuromuscular syndrome of flaccid muscle weakness that mimics signs seen in several human neuromuscular disorders such as congenital myasthenic syndromes, botulism, and neuroaxonal dystrophy. " 01/01/2004 - "Studies were conducted using harmaline, a tremorigen; scopolamine; methyl scopolamine; and 2,4-dithiobiuret (DTB), a compound that causes muscle weakness by interfering with cholinergic transmission at the neuromuscular junction. "
2.	Pheochromocytoma 01/01/1997 - "Effects of the paralytic agent 2,4-dithiobiuret on viability and morphology of rat pheochromocytoma (PC12) cells." 12/01/1995 - "Differential effects of 2,4-dithiobiuret on the synthesis and release of acetylcholine and dopamine from rat pheochromocytoma (PC12) cells."
3.	Congenital Myasthenic Syndromes (Myasthenia Gravis, Congenital) 12/01/2002 - "Chronic treatment of rodents with 2,4-dithiobiuret (DTB) induces a neuromuscular syndrome of flaccid muscle weakness that mimics signs seen in several human neuromuscular disorders such as congenital myasthenic syndromes, botulism, and neuroaxonal dystrophy. "
4.	Neuroaxonal Dystrophies (Neuroaxonal Dystrophy, Late Infantile) 12/01/2002 - "Chronic treatment of rodents with 2,4-dithiobiuret (DTB) induces a neuromuscular syndrome of flaccid muscle weakness that mimics signs seen in several human neuromuscular disorders such as congenital myasthenic syndromes, botulism, and neuroaxonal dystrophy. "
5.	Acute Intermittent Porphyria (Porphyria, Acute) 07/01/1984 - "Urinary excretion of porphyrin precursors delta-aminolevulinic acid (ALA) and porphobilinogen (PBG) and total porphyrins was measured during intoxication of rats with 2,4-dithiobiuret (DTB), a chemical which produces delayed-onset neuromuscular weakness, in an attempt to ascertain whether or not DTB poisoning in the rat would serve as an animal model of the neurologic symptoms of acute intermittent porphyria. "

Related Drugs and Biologics

1.	Cholinergic Agents (Cholinergics)
2.	Scopolamine (Hyoscine)
3.	Harmaline
4.	Porphyrins
5.	Porphobilinogen
6.	Dopamine (Intropin)
7.	Aminolevulinic Acid (Levulan)
8.	Acetylcholine (Acetylcholine Chloride)