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3,3-dimethylbutan-1-ol

structure

Also Known As:

3,3-dimethyl-1-butanol

Networked: 13 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Alcohols: 595
  - Fatty Alcohols: 172
    - Hexanols: 17
      - 3,3-dimethylbutan-1-ol: 13
Lipids: 114793
- Fatty Alcohols: 172
  - Hexanols: 17
    - 3,3-dimethylbutan-1-ol: 13

Experts

1.	Lu, Wenju: 2 articles (01/2022 - 10/2020)
2.	Wang, Tao: 2 articles (01/2022 - 10/2020)
3.	Chang-Chien, Guo-Ping: 2 articles (08/2021 - 01/2019)
4.	Hou, Chih-Yao: 2 articles (08/2021 - 01/2019)
5.	Hsu, Chien-Ning: 2 articles (08/2021 - 01/2019)
6.	Lin, Sufan: 2 articles (08/2021 - 01/2019)
7.	Tain, You-Lin: 2 articles (08/2021 - 01/2019)
8.	Shuai, Wei: 2 articles (08/2020 - 01/2020)
9.	Bao, Changlei: 1 article (01/2022)
10.	Hong, Cheng: 1 article (01/2022)

Related Diseases

1.	Inflammation (Inflammations) 08/01/2020 - "A high-choline diet exacerbates cardiac dysfunction, myocardial fibrosis, and inflammation in HFpEF mice, and 3,3-dimethyl-1-butanol ameliorates the high-choline diet-induced cardiac remodeling." 08/01/2020 - "Additionally, 3,3-dimethyl-1-butanol DMB markedly ameliorated cardiac diastolic dysfunction, myocardial fibrosis and inflammation in the choline-fed HFpEF mice. "
2.	Fibrosis (Cirrhosis) 08/01/2020 - "A high-choline diet exacerbates cardiac dysfunction, myocardial fibrosis, and inflammation in HFpEF mice, and 3,3-dimethyl-1-butanol ameliorates the high-choline diet-induced cardiac remodeling." 08/01/2020 - "Additionally, 3,3-dimethyl-1-butanol DMB markedly ameliorated cardiac diastolic dysfunction, myocardial fibrosis and inflammation in the choline-fed HFpEF mice. "
3.	Hypertension (High Blood Pressure) 08/30/2021 - "Maternal 3,3-Dimethyl-1-Butanol Therapy Protects Adult Male Rat Offspring against Hypertension Programmed by Perinatal TCDD Exposure." 01/01/2019 - "Whether maternal 3,3-dimethyl-1-butanol (DMB, an inhibitor for TMA formation) treatment or the predominant SCFA acetate supplementation can prevent programed hypertension induced by a high-fructose diet (HFD) exposure during pregnancy and lactation in adult male offspring is examined. " 08/30/2021 - "We tested a hypothesis that maternal 3,3-Dimethyl-1-butanol (DMB, a TMA inhibitor) therapy prevents 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure-induced hypertension in adult offspring relevant to alterations of gut microbiota-derived metabolites, the mediation of aryl hydrocarbon receptor (AHR) signaling, and the renin-angiotensin system (RAS). " 05/01/2019 - "We examined whether trimethylamine-N-oxide (TMAO) plays a role in endothelial dysfunction and hypertension in the reduced uterine perfusion pressure (RUPP) rat model of preeclampsia (PE). Methods: Normal pregnant rats and RUPP rats were treated without or with 3,3-Dimethyl-1-butanol (DMB, a TMAO inhibitor) from gestational day 14. Results: On day 19 of gestation, RUPP rats had higher plasma TMAO, impaired vasodilation and hypertension, decreased interleukin (IL)-10, increased superoxide production and proinflammatory cytokines in the aorta. "
4.	Diabetic Cardiomyopathies 11/01/2022 - "Then, diabetic rats were divided into two groups based on the presence or absence of 3,3-dimethyl-1-butanol (DMB, a specific TMAO inhibitor) in drinking water: the diabetic cardiomyopathy (DCM) group and the DCM + DMB group. "
5.	Atherosclerosis 11/01/2017 - "Moreover, 3,3-dimethyl-1-butanol (DMB), an inhibitor of microbial trimethylamine (TMA) production, was used to determine the contribution of TMA-oxide (TMAO) to IHC-induced atherosclerosis. "

Related Drugs and Biologics

1.	Choline (Choline Chloride)
2.	trimethyloxamine (trimethylamine N-oxide)
3.	Drinking Water
4.	Monocrotaline
5.	Lyases
6.	trimethylamine
7.	Aryl Hydrocarbon Receptors (Aryl Hydrocarbon Receptor)
8.	Cytokines
9.	Biomarkers (Surrogate Marker)
10.	Superoxides (Superoxide)

Related Therapies and Procedures

1.	Therapeutics
2.	Ligation