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5,5'-dihydroxylysylnorleucine

Also Known As:

5,5'-dihydroxy-Lys-Nle; 5,5'-dihydroxylysinonorleucine; DHLNL; delta,delta'-dihydroxylysylnonorleucine

Networked: 5 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Oligopeptides: 519
    - Dipeptides: 945
      - 5,5'-dihydroxylysylnorleucine: 5

Related Diseases

1.	Fibrosis (Cirrhosis) 02/01/1990 - "These results are consistent with data from animal models of fibrotic lung disease, suggesting that increases in the DHLNL:HLNL ratio of lung collagen may serve as a marker of an acute fibrotic episode, whereas increased lung collagen OHP content serves as a marker of chronic lung fibrosis. " 04/01/1994 - "In this study, we asked if taurine and niacin would block the increase in DHLNL and OHP in the multidose bleomycin hamster model of lung fibrosis. " 02/01/1990 - "We suggest that the underlying mechanism for the changes in DHLNL content in (pre)fibrotic acutely injured lung tissue and in OHP content in long-term fibrosis may be an increase in the activity of lysyl hydroxylase, a key intracellular enzyme responsible for a specific post-translational modification of collagen."
2.	Interstitial Lung Diseases (Interstitial Lung Disease) 02/01/1990 - "Lung tissue from patients with interstitial lung disease (ILD), adult respiratory distress syndrome (ARDS), and control subjects with no obvious fibrotic lung disease was analyzed for its content of the collagen cross-links hydroxylysinonorleucine (HLNL), dihydroxylysinonorleucine (DHLNL), and hydroxypyridinium (OHP). "
3.	Wounds and Injuries (Trauma) 01/01/1991 - "Treatment with BAPN (333 mg/kg BW/day) reduced the strength of the wounds by 59%, the HLNL by 50% and the DHLNL 57%, whereas the deposition of hydroxyproline did not seem to be influenced by BAPN treatment. " 01/01/1991 - "The mechanical strength of skin wounds as well as the deposition of hydroxyproline and KB3H4 reducible hydroxylysinonorleucine (HLNL) and dihydroxylysinonorleucine (DHLNL) cross-links in subcutaneously implanted cellulose sponges have been investigated in rats treated with aminoguanidine (AG) or beta-aminopropionitrile (BAPN). "
4.	Respiratory Distress Syndrome (Acute Respiratory Distress Syndrome) 02/01/1990 - "Lung tissue from patients with interstitial lung disease (ILD), adult respiratory distress syndrome (ARDS), and control subjects with no obvious fibrotic lung disease was analyzed for its content of the collagen cross-links hydroxylysinonorleucine (HLNL), dihydroxylysinonorleucine (DHLNL), and hydroxypyridinium (OHP). "
5.	Lung Diseases (Lung Disease) 02/01/1990 - "These results are consistent with data from animal models of fibrotic lung disease, suggesting that increases in the DHLNL:HLNL ratio of lung collagen may serve as a marker of an acute fibrotic episode, whereas increased lung collagen OHP content serves as a marker of chronic lung fibrosis. " 02/01/1990 - "Lung tissue from patients with interstitial lung disease (ILD), adult respiratory distress syndrome (ARDS), and control subjects with no obvious fibrotic lung disease was analyzed for its content of the collagen cross-links hydroxylysinonorleucine (HLNL), dihydroxylysinonorleucine (DHLNL), and hydroxypyridinium (OHP). "

Related Drugs and Biologics

1.	Taurine
2.	Niacin (Nicotinic Acid)
3.	Bleomycin (Blenoxane)
4.	delta-hydroxylysylnorleucine
5.	2-Oxoglutarate 5-Dioxygenase Procollagen-Lysine (Lysyl Hydroxylase)
6.	Hydroxyproline (4 Hydroxyproline)
7.	Glycated Hemoglobin (Glycosylated Hemoglobin)
8.	Enzymes
9.	Collagen
10.	Cellulose