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diglyme
Also Known As:
DGDME; bis(2-methoxyethyl)ether; diethylene glycol dimethyl ether
Networked:
5
relevant articles (
0
outcomes,
1
trials/studies)
Bio-Agent Context: Research Results
Organic Chemicals: 133
Alcohols: 595
Glycols: 38
Ethylene Glycols: 8
diglyme: 5
Ethers: 242
Methyl Ethers: 19
diglyme: 5
Experts
1.
Doelker, E
: 1 article (01/2002)
2.
Laurent, A
: 1 article (01/2002)
3.
Mottu, F
: 1 article (01/2002)
4.
Rüfenacht, D A
: 1 article (01/2002)
Related Diseases
1.
Atrophy
12/15/1989 - "
At 1100 ppm diglyme or 300 ppm 2-ME, marked testicular atrophy was found affecting all spermatogenic stages.
"
06/01/1983 - "
Other studies have demonstrated that testicular atrophy or infertility follow treatment of males with EGME, ethylene glycol monomethyl ether acetate (EGMEA), EGEE, EGEEA, diethylene glycol dimethyl ether (diEGdiME), and diethylene glycol monoethyl ether (diEGEE).
"
08/01/1984 - "
In regard to the methyl ethers of other glycols, there is no convincing evidence that propylene glycol monomethyl ether, diethylene glycol monomethyl ether or diethylene glycol dimethyl ether causes testicular atrophy in mice.
"
2.
Infertility (Sterility)
06/01/1983 - "
Other studies have demonstrated that testicular atrophy or infertility follow treatment of males with EGME, ethylene glycol monomethyl ether acetate (EGMEA), EGEE, EGEEA, diethylene glycol dimethyl ether (diEGdiME), and diethylene glycol monoethyl ether (diEGEE).
"
3.
Fetal Weight
05/01/1998 - "
Embryo viability was unaffected by concentrations of diglyme as high as 100 ppm. 2ME produced increased liver weights and depressed feed consumption at 25 ppm. Embryo-fetal toxicity was evident as a concentration-related decrease in fetal weight at diglyme concentrations as high as 100 ppm (and with 2ME).
"
4.
Intracranial Aneurysm (Cerebral Aneurysm)
01/01/2002 - "
In conclusion, cellulose acetate iodobenzoate mixed esters dissolved in diglyme or dimethyl isosorbide (dimethyl sulfoxide is probably less appropriate because of its toxicity and hemolytic properties) could be useful embolic liquids for the treatment of cerebral aneurysms or arteriovenous malformations.
"
5.
Arteriovenous Malformations (Arteriovenous Malformation)
01/01/2002 - "
In conclusion, cellulose acetate iodobenzoate mixed esters dissolved in diglyme or dimethyl isosorbide (dimethyl sulfoxide is probably less appropriate because of its toxicity and hemolytic properties) could be useful embolic liquids for the treatment of cerebral aneurysms or arteriovenous malformations.
"
Related Drugs and Biologics
1.
2-methoxyethanol acetate
2.
carbitol (diethylene glycol monoethyl ether)
3.
Methyl Ethers
4.
Mercaptoethanol (2 Mercaptoethanol)
5.
Glycols
6.
Esters
7.
Dimethyl Sulfoxide (DMSO)
8.
diethylene glycol monomethyl ether
9.
2,5-dimethylisosorbide
10.
propylene glycol methyl ether (propylene glycol monomethyl ether)