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desethylchloroquine

RN given refers to parent cpd
Also Known As:
deethylchloroquine; desethylchloroquine dihydrochloride; desethylchloroquine hydrochloride; desethylchloroquine oxalate (1:2); monodesethylchloroquine
Networked: 21 relevant articles (1 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Melgar, Viviana: 1 article (10/2012)
2. Garnica, Cecilia: 1 article (10/2012)
3. Yucra, Omar: 1 article (10/2012)
4. Nakao, Gladys: 1 article (10/2012)
5. Moscoso, Manuel: 1 article (10/2012)
6. Añez, Arletta: 1 article (10/2012)
7. Navarro-Costa, Dennis: 1 article (10/2012)
8. Arteaga, Ricardo: 1 article (10/2012)
9. Hirt, Deborah: 1 article (11/2010)
10. Résiére, Dabor: 1 article (11/2010)

Related Diseases

1. Malaria
05/01/1987 - "A total of 178 children in 3 regions were treated; 174 (98%) responded successfully, which required a greater than or equal to 75% reduction in parasites by day 2 and elimination of parasites by day 7. All 4 failures had low blood levels of chloroquine and desethylchloroquine at day 7. A single dose of chloroquine for treating malaria can be considered for those areas of Africa where the efficacy of such therapy is documented, and where an antimalarial drug sensitivity monitoring system is operating."
02/01/1992 - "A study of chloroquine and desethylchloroquine plasma levels in patients infected with sensitive and resistant malaria parasites."
01/01/1988 - "In a study in western Kenya of malaria-infected adult women who had been treated with chloroquine, we compared the level of chloroquine and its principal metabolite, desethylchloroquine, in urine, measured using a newly developed modified Haskins test, with the level of chloroquine in whole blood, determined by high-performance liquid chromatography. "
06/01/1997 - "Data from our laboratory may help explain this difference; among 91 Indonesian patients with malaria, the mean whole blood levels of chloroquine (CQ) and desethylchloroquine (DCQ) were 141 ng/ml (95% confidence interval = 115-167) on day 28 after initiating standard therapy (25 mg base/kg in three doses over a 48-hr period). "
01/01/1987 - "The concentrations of chloroquine and desethylchloroquine in the blood of 10 healthy adult Swedish volunteers who had been taking 310 mg chloroquine base once a week for at least 8 months for malaria prophylaxis were measured. "
2. Cerebral Malaria
3. Seizures (Seizure)
4. Parasitemia
5. Pruritus (Itching)

Related Drugs and Biologics

1. Chloroquine (Aralen)
2. Promethazine (Promet)
3. Hydroxychloroquine (Plaquenil)
4. N,N-dideethylchloroquine
5. sulfadoxine-pyrimethamine (Fansidar)