|1.||Melgar, Viviana: 1 article (10/2012)|
|2.||Garnica, Cecilia: 1 article (10/2012)|
|3.||Yucra, Omar: 1 article (10/2012)|
|4.||Nakao, Gladys: 1 article (10/2012)|
|5.||Moscoso, Manuel: 1 article (10/2012)|
|6.||Añez, Arletta: 1 article (10/2012)|
|7.||Navarro-Costa, Dennis: 1 article (10/2012)|
|8.||Arteaga, Ricardo: 1 article (10/2012)|
|9.||Hirt, Deborah: 1 article (11/2010)|
|10.||Résiére, Dabor: 1 article (11/2010)|
05/01/1987 - "A total of 178 children in 3 regions were treated; 174 (98%) responded successfully, which required a greater than or equal to 75% reduction in parasites by day 2 and elimination of parasites by day 7. All 4 failures had low blood levels of chloroquine and desethylchloroquine at day 7. A single dose of chloroquine for treating malaria can be considered for those areas of Africa where the efficacy of such therapy is documented, and where an antimalarial drug sensitivity monitoring system is operating."
02/01/1992 - "A study of chloroquine and desethylchloroquine plasma levels in patients infected with sensitive and resistant malaria parasites."
01/01/1988 - "In a study in western Kenya of malaria-infected adult women who had been treated with chloroquine, we compared the level of chloroquine and its principal metabolite, desethylchloroquine, in urine, measured using a newly developed modified Haskins test, with the level of chloroquine in whole blood, determined by high-performance liquid chromatography. "
06/01/1997 - "Data from our laboratory may help explain this difference; among 91 Indonesian patients with malaria, the mean whole blood levels of chloroquine (CQ) and desethylchloroquine (DCQ) were 141 ng/ml (95% confidence interval = 115-167) on day 28 after initiating standard therapy (25 mg base/kg in three doses over a 48-hr period). "
01/01/1987 - "The concentrations of chloroquine and desethylchloroquine in the blood of 10 healthy adult Swedish volunteers who had been taking 310 mg chloroquine base once a week for at least 8 months for malaria prophylaxis were measured. "
10/01/2012 - "Blood levels of chloroquine and desethylchloroquine in patients with treatment failure showed values below 70 ng/ml on the day of reappearance of parasitemia. "
10/01/2012 - "Blood levels of chloroquine and desethylchloroquine were measured on day 2 and on the day of reappearance of parasitemia. "
04/01/2003 - "All recurrent parasitemias occurred with whole blood levels of chloroquine plus desethylchloroquine exceeding 100 ng/ml. These findings document almost complete failure of chloroquine against P. "
11/01/2003 - "Two of these patients had chloroquine-resistant infections, based on polymerase chain reaction-single-stranded conformational polymorphism genotyping and chloroquine-desethylchloroquine blood levels, which were > or = 97 ng/mL at the time of the reappearance of parasitemia. "
03/01/2000 - "The pharmacokinetics of chloroquine and its main metabolite desethylchloroquine have been carried out in volunteers with and without chloroquine-induced pruritus. "
03/01/2000 - "The disposition of chloroquine and its main metabolite desethylchloroquine in volunteers with and without chloroquine-induced pruritus: evidence for decreased chloroquine metabolism in volunteers with pruritus."
01/01/1989 - "In the absence of promethazine there appears to be an extensive metabolism of chloroquine in hypersensitive individuals to produce monodesethylchloroquine which probably determines the degree of pruritus experienced by an individual."