desethylchloroquine

metabolite of chloroquine

Also Known As:

7-chloro-4-((4-(ethylamino)-1-methylbutyl)amino)-quinoline; N-deethylchloroquine; N4-(7-chloro-4-quinolinyl)-n1-ethyl-1,4-pentanediamine; deethylchloroquine; desethylchloroquine dihydrochloride; desethylchloroquine hydrochloride; desethylchloroquine oxalate (1:2); monodesethylchloroquine; monoethyl chloroquine

Networked: 27 relevant articles (1 outcomes, 5 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Quinolines: 146
      - Aminoquinolines: 29
        Chloroquine: 7498
        desethylchloroquine: 27

Experts

1.	Alvarez, Jean Claude: 1 article (02/2022)
2.	Annane, Djillali: 1 article (02/2022)
3.	Davido, Benjamin: 1 article (02/2022)
4.	Etting, Isabelle: 1 article (02/2022)
5.	Larabi, Islam Amine: 1 article (02/2022)
6.	Moine, Pierre: 1 article (02/2022)
7.	Simon, Nicolas: 1 article (02/2022)
8.	Acton, Dena: 1 article (12/2021)
9.	Alam, Imranul: 1 article (12/2021)
10.	Bruzzaniti, Angela: 1 article (12/2021)

Related Diseases

1.	Malaria 02/01/1992 - "A study of chloroquine and desethylchloroquine plasma levels in patients infected with sensitive and resistant malaria parasites." 01/01/1988 - "In a study in western Kenya of malaria-infected adult women who had been treated with chloroquine, we compared the level of chloroquine and its principal metabolite, desethylchloroquine, in urine, measured using a newly developed modified Haskins test, with the level of chloroquine in whole blood, determined by high-performance liquid chromatography. " 01/01/1987 - "The concentrations of chloroquine and desethylchloroquine in the blood of 10 healthy adult Swedish volunteers who had been taking 310 mg chloroquine base once a week for at least 8 months for malaria prophylaxis were measured. " 01/01/1987 - "Chloroquine and desethylchloroquine concentrations during regular long-term malaria prophylaxis." 05/01/1984 - "[Distribution of chloroquine and desethylchloroquine in blood, plasma and erythrocytes of healthy subjects and malaria patients. "
2.	Vivax Malaria 12/21/2019 - "The aim of the present study was to estimate the extent of sub-dosing of chloroquine in children and adolescents with vivax malaria using an age-based dose regimen, in addition to investigating the influence of age on the plasma concentrations of chloroquine and desethylchloroquine. " 10/01/1999 - "Determination of chloroquine and desethylchloroquine in plasma and blood cells of Plasmodium vivax malaria cases using liquid chromatography."
3.	Cerebral Malaria 12/01/2000 - "Our study was designed to investigate the relationship between blood levels of chloroquine (CQ), its metabolite desethylchloroquine (DCQ), and seizures in children admitted to hospital with cerebral malaria. "
4.	Seizures (Absence Seizure) 12/01/2000 - "Our study was designed to investigate the relationship between blood levels of chloroquine (CQ), its metabolite desethylchloroquine (DCQ), and seizures in children admitted to hospital with cerebral malaria. "
5.	Bone Resorption 12/01/2021 - "We tested this hypothesis in cell culture studies using osteoclasts derived from wild-type (WT or ADO2+/+) and ADO2 heterozygous (ADO2+/-) mice and found that CQ and its metabolite desethylchloroquine (DCQ), significantly increased ADO2+/- osteoclasts bone resorption activity in vitro, whereas bone resorption of ADO2+/+ osteoclasts was increased only by DCQ. "

Related Drugs and Biologics

1.	Chloroquine (Aralen)
2.	Antimalarials (Antimalarial Agents)
3.	Hydroxychloroquine (Plaquenil)
4.	cletoquine
5.	N,N-dideethylchloroquine
6.	Promethazine (Promet)
7.	pyrimethamine drug combination fanasil (Fansidar)

Related Therapies and Procedures

1.	Therapeutics