2-(4-chlorophenylthio)triethylamine

causes accumulation of lycopene at expense of other carotenoids in carotenogenic tissues; RN given refers to parent cpd

Also Known As:

2-(4-chlorophenylthio)triethylamine hydrochloride; CPTA

Networked: 18 relevant articles (2 outcomes, 4 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amines: 4871
  - Ethylamines: 5
    - 2-(4-chlorophenylthio)triethylamine: 18

Experts

1.	Patel, Ankur: 2 articles (09/2022 - 10/2018)
2.	Tan, Bien Soo: 2 articles (09/2022 - 10/2018)
3.	Tay, Kiang Hiong: 2 articles (09/2022 - 10/2018)
4.	Ametamey, Simon: 2 articles (01/2007 - 05/2003)
5.	Grünberg, Jürgen: 2 articles (01/2007 - 05/2003)
6.	Honer, Michael: 2 articles (01/2007 - 05/2003)
7.	Novak-Hofer, Ilse: 2 articles (01/2007 - 05/2003)
8.	Schubiger, P August: 2 articles (01/2007 - 05/2003)
9.	Zimmermann, Kurt: 2 articles (01/2007 - 05/2003)
10.	Chandramohan, Sivanathan: 1 article (09/2022)

Related Diseases

1.	Neoplasms (Cancer) 05/01/2003 - "CPTA-labeled antibody achieved the best tumor to normal tissue ratios when biodistributions of the different (67)Cu-chCE7 conjugates were assessed in tumor-bearing mice. " 04/01/1997 - "Compared with MAb-chCE7 F(ab')2 fragments labeled by the CPTA ligand, labels using the DO3A ligand showed improved biodistributions resulting, 48 hr postinjection, in a 4-fold increase in tumor uptake and a 4-fold reduction of radioactivity in the kidneys." 09/01/2021 - "Seminal proteomic studies in the area of ovarian cancer, such as the PROVAR and CPTA studies are discussed, along side recent research, such as that highlighting the central role of methyltransferase nicotinamide N-methyltransferase as the metabolic regulation of cancer progression in the tumour stroma. " 04/01/1997 - "Analysis of tumor extracts by gel filtration chromatography and high-pressure liquid chromatography (HPLC) showed that over the period of 4 days radioactivity was present both in a high M(r) form, consisting of the MAb/antigen complex, as well as in a low M(r) form, consisting of the copper complex attached to short peptides, including the lys-CPTA complex. "
2.	Right Ventricular Dysfunction 02/01/2017 - "To evaluate the feasibility and the efficacy of computed tomography pulmonary angiography (CTPA) in differentiating acute pulmonary embolism (PE) patients with or without right ventricular dysfunction and to evaluate the severity of right ventricular dysfunction in acute PE patients with CPTA. "
3.	Pulmonary Embolism 02/01/2017 - "To evaluate the feasibility and the efficacy of computed tomography pulmonary angiography (CTPA) in differentiating acute pulmonary embolism (PE) patients with or without right ventricular dysfunction and to evaluate the severity of right ventricular dysfunction in acute PE patients with CPTA. "
4.	Ovarian Neoplasms (Ovarian Cancer) 09/30/2020 - "In this study, using univariate Cox analysis and online CPTA analysis, we found that WTAP was a poor prognostic factor for ovarian cancer, and its protein expression level was higher in ovarian cancer than in normal tissue. " 09/01/2021 - "Seminal proteomic studies in the area of ovarian cancer, such as the PROVAR and CPTA studies are discussed, along side recent research, such as that highlighting the central role of methyltransferase nicotinamide N-methyltransferase as the metabolic regulation of cancer progression in the tumour stroma. " 01/15/2007 - "Biodistributions of (67)Cu-4-(1,4,8,11-tetraazacyclotetradec-1-yl)-methyl benzoic acid tetrachloride (CPTA)-labeled mutant antibodies were measured in nude mice bearing SKOV3ip human ovarian cancer metastases. "
5.	Neuroblastoma 11/01/1999 - "67Cu-labeled conjugates were compared with the original CPTA- and DO3A-F(ab')2 in vitro and in vivo in mice bearing neuroblastoma xenografts. " 12/01/2007 - "Cytotoxicity studies on Neuro2A murine neuroblastoma cells evidenced absence of toxicity of these copolymers up to 300 microg/ml unlike linear polyethylenimine (LPEI) that was highly toxic already at 20 microg/ml. PAHy-CPTA copolymers did not induce any erythrocyte aggregation up to 1 mg/ml. Cellular interaction studies of PAHy-CPTA polyplexes evidenced a faster binding of these polyplexes with cells compared to DNA/LPEI polyplexes. " 04/01/1997 - "ChCE7, an internalizing, neuroblastoma-specific monoclonal antibody (MAb), and its F(ab')2 fragments were derived with the bifunctional ligand 4-(1,4,8,11-tetraazacyclotetradec-1-yl)-methyl benzoic acid tetrahydrochloride (CPTA) and labeled with the potential therapeutic nuclide 67Cu. " 11/01/1999 - "The peptide-linked copper chelators CPTA-triglycyl-L-p-isothiocyanato-phenylalanine (CPTA-R1-NCS) as well as DOTA-triglycyl-L-p-isocyanato-phenylalanine (DOTA-R1-NCS) were synthesized and coupled to F(ab')2 fragments of the anti-neuroblastoma monoclonal antibody (MAb) chCE7. "

Related Drugs and Biologics

1.	Ligands
2.	4- ((1,4,8,11- tetraazacyclotetradec- 1- yl)methyl)benzoic acid
3.	Nicotinamide N-Methyltransferase
4.	Proteins (Proteins, Gene)
5.	Polyethyleneimine
6.	Methyltransferases
7.	DNA (Deoxyribonucleic Acid)
8.	Benzoic Acid (Potassium Benzoate)
9.	Peptides (Polypeptides)
10.	Copper

Related Therapies and Procedures

1.	Carotid Endarterectomy
2.	Radiotherapy
3.	Drug Therapy (Chemotherapy)