copper thionein

formed from metallothionein by reaction with copper; not the same as THIONEINE (an ergot alkaloid); GenBank K02204 (CUP1-1)

Also Known As:

Cu(I)-thionein; Cu-thionein; copper metallothionein; copper-thionein

Networked: 17 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Metalloproteins: 164
    - Metallothionein: 1832
      - copper thionein: 17

Experts

1.	Campbell, Marcus L: 1 article (02/2015)
2.	Gerstein, Aleeza C: 1 article (02/2015)
3.	Kuzmin, Anastasia: 1 article (02/2015)
4.	Lo, Dara S: 1 article (02/2015)
5.	Ono, Jasmine: 1 article (02/2015)
6.	Otto, Sarah P: 1 article (02/2015)
7.	Lui, Edmund M K: 1 article (01/2006)
8.	Suntres, Zacharias E: 1 article (01/2006)

Related Diseases

1.	Neoplasms (Cancer) 10/09/1989 - "The elevated Cu-thionein concentration in melanoma tumor tissue is not yet understood. " 03/01/1986 - "We concluded that the excessive copper in the cancer cells was aggregated lysosomal copper metallothionein, and that it might not be carcinogenic but stored by an altered metabolism of copper and copper-binding proteins with the neoplastic transformation." 01/01/1989 - "The occurrence of Cu-thionein in leucocytes and the excretion of the intact Cu(I)-thiolate protein is of considerable interest with respect to the observed elevated copper levels in white blood cells and plasma during tumor malignancies and inflammatory processes."
2.	Menkes Kinky Hair Syndrome (Menkes Disease) 11/01/1997 - "Copper-metallothionein in the kidney of macular mice: a model for Menkes disease." 02/01/1985 - "Menkes' disease, an inherited disorder of copper metabolism, is characterized by the accumulation of excess copper-metallothionein in certain tissues and cell types. " 01/01/1980 - "Abnormal copper-thionein synthesis and impaired copper utilization in mutated brindled mice: model for Menkes' disease."
3.	Rheumatic Diseases (Rheumatism) 06/01/1993 - "Gel-filtered sera of patients with various inflammatory and autoimmune rheumatic diseases (N = 354) were screened for the presence of the inflammation marker Cu-thionein. " 01/01/1993 - "The NOx levels were positively correlated with the serum titers of antinuclear antibodies (r = 0.77) and negatively correlated with Cu-thionein levels (r = 0.94), reflecting a high steady-state concentration of free radicals generated during inflammatory and autoimmune rheumatic diseases." 01/01/1993 - "Reactive nitrogen intermediates, antinuclear antibodies and copper-thionein in serum of patients with rheumatic diseases." 01/01/1993 - "Sera from 354 patients with various inflammatory and autoimmune rheumatic diseases were screened for the presence of reactive nitrogen intermediates, antinuclear antibodies and the anti-oxidase copper-thionein (Cu-thionein), and compared to sera from healthy donors and patients with non-rheumatic diseases including AIDS, various internal as well as neurological diseases and carcinoma of different organs. "
4.	Inflammation (Inflammations) 06/01/1993 - "Gel-filtered sera of patients with various inflammatory and autoimmune rheumatic diseases (N = 354) were screened for the presence of the inflammation marker Cu-thionein. " 11/01/1999 - "Gout involves seven aspects: (1) uric acid overproduction from increased purines in the diet; (2) uric acid overproduction from ATP degradation; (3) uric acid overproduction from increased de novo synthesis of purines; (4) uric acid overproduction from increased DNA breakdown from cell damage; (5) decreased uric acid elimination, caused by molybdenum and sulfur binding to copper in the kidneys; (6) precipitation of sodium urate-iron crystals in the joints due to high ferritin and saturated transferrin and low CuZn-SOD and Cu-thionein in the joint; (7) development of inflammation, triggered by tyrosine bonding to the sodium-urate-iron crystals and being transformed by tyrosine kinase. "
5.	Hepatocellular Carcinoma (Hepatoma) 09/06/1994 - "Role of cytosolic copper, metallothionein and glutathione in copper toxicity in rat hepatoma tissue culture cells." 07/05/1990 - "In view of the inability of copper-thionein to reconstitute Cu,Zn-superoxide dismutase and of the detection of copper.GSH complexes in copper-over-loaded hepatoma cells (Freedman, J.H., Ciriolo, M.R., and Peisach, J. "

Related Drugs and Biologics

1.	Copper
2.	Proteins (Proteins, Gene)
3.	Glutathione (Reduced Glutathione)
4.	copper thionein
5.	Biomarkers (Surrogate Marker)
6.	Uric Acid (Urate)
7.	Tyrosine (L-Tyrosine)
8.	Transferrin (beta 2 Transferrin)
9.	Sulfur
10.	Purines