|1.||Krajcovicova, I: 1 article (01/2013)|
|2.||Krcmery, V: 1 article (01/2013)|
|3.||Bencova, V: 1 article (01/2013)|
|4.||Bella, V: 1 article (01/2013)|
07/01/1985 - "In the present study, the possibility that BCPN dissolved in urine may induce tumors was explored using a short-term screening assay. "
01/01/1989 - "In late experimental period (100 wks approximately) administered BBN (400 mg/day) to five dogs, the dog that was found initial tumor earliest (103 wk) excreted the largest amounts of BCPN in the urine. "
07/15/1987 - "A time-dependent increase was observed in the amount of N-nitrosobutyl(3-carboxypropyl)amine formed and simultaneous disappearance of N-nitrosobutyl(4-hydroxybutyl)amine added, indicating that the bladder can metabolize N-nitrosobutyl(4-hydroxybutyl)amine to the metabolite considered responsible for tumor induction in the urinary bladder of laboratory animals. "
07/01/1985 - "Based on the current findings together with other available data, it is suggested that urothelial cells have a very limited capability to activate BCPN to the ultimate carcinogen, and require continuous contact with the carcinogen to respond with tumor formation."
07/01/1985 - "No tumor developed, however, in the heterotropically transplanted rat urinary bladders (HTBs) following repeated instillation of BCPN dissolved in physiological saline. "
|3.||Urinary Bladder Neoplasms (Bladder Cancer)
12/01/1980 - "A possible correlation of the urinary excretion of BCPN with selective induction of bladder tumors by BBN in rats is discussed in relation to the carcinogenic action of BCPN."
12/01/1980 - "The omega-oxidation of DBN to BCPN is responsible for the induction of bladder tumors in rats, while the products of the (omega-1)- or (omega-2)-oxidation may be involved in tumor induction in the liver."
01/01/1983 - "It was found that 0.5% disulfiram significantly reduced the incidence of bladder cancer, decreasing from 30/30 (100%) in the group receiving BCPN alone to 3/30 (10%) in the group fed the disulfiram diet. "
02/01/1983 - "Since N-butyl-N-(3-carboxypropyl) nitrosamine (BCPN) and N-ethyl-N-(3-carboxypropyl) nitrosamine (ECPN) had been found to be the principal urinary metabolites which are responsible for the induction of bladder tumors by BBN or DBN and EHBN, respectively, in rats, acidic urinary metabolites with the N-nitroso moiety were isolated and determined by a colorimetric method after oral administration of these nitrosamines to rats, mice, hamsters, guinea pigs, and dogs. "
01/01/1983 - "The objective of this study was to determine if disulfiram would inhibit the induction of bladder cancer in rats given BCPN, as reported for BHBN (Cancer Res., 39, 3040, 1979). "
|4.||Liver Cell Adenoma (Hepatocellular Adenoma)
|2.||Segmental Mastectomy (Lumpectomy)
|3.||Modified Radical Mastectomy (Mastectomy, Modified)