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bufarenogin

structure

Networked: 3 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Polycyclic Compounds: 6
- Fused-Ring Compounds
  - Steroids: 70059
    - Cardanolides
      - Cardiac Glycosides: 1002
        Bufanolides: 91
        bufarenogin: 3

Experts

1.	Ding, Jin: 2 articles (05/2015 - 01/2015)
2.	Wang, Hongyang: 2 articles (05/2015 - 01/2015)
3.	Han, Qinrui: 1 article (01/2021)
4.	Li, Yuan: 1 article (01/2021)
5.	Sun, Xuegang: 1 article (01/2021)
6.	Wu, Liyi: 1 article (01/2021)
7.	Zhang, Chun: 1 article (01/2021)
8.	Zhang, Yongbin: 1 article (01/2021)
9.	Cheng, Zhuo: 1 article (05/2015)
10.	He, Guoping: 1 article (05/2015)

Related Diseases

1.	Colorectal Neoplasms (Colorectal Cancer) 01/01/2021 - "In this study, we investigated the inhibitory effects of bufarenogin on the growth and metastasis of colorectal cancer (CRC), particularly its effects on mediating intrinsic signaling pathways that initiate apoptosis. "
2.	Neoplasm Metastasis (Metastasis) 01/01/2021 - "In this study, we investigated the inhibitory effects of bufarenogin on the growth and metastasis of colorectal cancer (CRC), particularly its effects on mediating intrinsic signaling pathways that initiate apoptosis. " 01/01/2021 - "Bufarenogin induced intrinsic apoptosis through the cooperation of Bax and adenine-nucleotide translocator and inhibited the metastasis and growth of orthotopical CRC cells."
3.	Hepatocellular Carcinoma (Hepatoma) 05/10/2015 - "Mechanistic study revealed that ψ-Bufarenogin impaired the activation of MEK/ERK pathway, which is essential in the proliferation of hepatoma cells. " 05/10/2015 - "Moreover, ψ-Bufarenogin decreased the number of hepatoma stem cells through Sox2 depression and exhibited synergistic effect with conventional chemotherapeutics. " 05/10/2015 - "Herein we report ψ-Bufarenogin, a novel active compound that we isolated from the extract of toad skin, exhibited potent therapeutic effect in xenografted human hepatoma without notable side effects. "
4.	Neoplasms (Cancer) 01/01/2015 - "ψ-Bufarenogin, a lead compound of anti-cancer drug." 01/01/2021 - "Bufarenogin, an active anti-tumor constituent of toad venom, shows anti-tumor activity. " 05/10/2015 - "ψ-Bufarenogin, a novel anti-tumor compound, suppresses liver cancer growth by inhibiting receptor tyrosine kinase-mediated signaling."
5.	B-Cell Lymphoma (Lymphoma, B Cell) 01/01/2021 - "Bufarenogin induced B-cell lymphoma 2-associated X protein (Bax)-dependent intrinsic apoptosis, as demonstrated by mitochondrial translocation of Bax and cytoplasm release of HCT116 wild-type cells and cytochrome C (soluble pro-apoptotic factors). "

Related Drugs and Biologics

1.	Therapeutic Uses
2.	Cytochromes c (Cytochrome c)
3.	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)
4.	Proteins (Proteins, Gene)
5.	Amphibian Venoms
6.	Adenine Nucleotides