ascofuranone

06/01/2003 - "Consecutive administration of ascofuranone without glycerol was found to have therapeutic efficacy against Trypanosoma brucei brucei infection in mice. "
01/01/2018 - "Trypanosome alternative oxidase is an exciting target for controlling the infection; it is unique to the parasite, and inhibition of this enzyme with the natural product ascofuranone has shown to clear in vivo infections. "
01/01/2019 - "The antibiotic ascofuranone (AF) proved a much stronger TAO inhibitor and was able to cure Trypanosoma vivax infections in mice without glycerol and at much lower doses, providing an important proof of concept milestone. "

06/11/2010 - "The current study presents that ascofuranone isolated from a phytopathogenic fungus, Ascochyta viciae, has antitumor activity against various transplantable tumors and a considerable hypolipidemic activity. "
01/01/2023 - "Ascofuranone (AF), a meroterpenoid isolated from various filamentous fungi, including Acremonium egyptiacum, has been reported as a potential lead candidate for drug development against parasites and cancer. "
10/01/2020 - "We found that ascofuranone suppressed IGF-1-induced cell migration, invasion and motility in multiple cancer cell lines. "
07/01/2010 - "Ascofuranone has been shown to have antitumor activity, but the precise molecular mechanism by which it inhibits the proliferation of cancer cells remains unclear. "
07/01/1983 - "Ascofuranone (AF) has antitumor protective property on experimental tumors. "

01/01/2012 - "In vivo study suggests that ascofuranone is a promising candidate for chemotherapeutic agents to treat African trypanosomiasis."
09/01/2006 - "Under the grant support from DNDi, a Japanese group is developing a new drug, ascofuranone, for African trypanosomiasis without any detectable side effects. "
02/01/1997 - "Our findings suggest that ascofuranone might be a promising candidate for the chemotherapeutic agents of African trypanosomiasis."
10/30/1996 - "Our findings suggest that ascofuranone might be a promising candidate for the chemotherapeutic agents of African trypanosomiasis."
03/01/2006 - "Our present results strongly suggest that ascofuranone is also an effective tool in chemotherapy against African trypanosomiasis in domestic animals."

02/01/2010 - "Using ascofuranone as a seed compound, further study of QPO inhibitors could provide novel chemotherapeutic strategies for controlling localized aggressive periodontitis."

10/01/2009 - "In this study, to identify proteins potentially involved in TGF-beta1-induced fibrosis processes, we performed a proteomic analysis of TGF-beta1-induced normal rat kidney cells exposed to ascofuranone (AF). "
10/01/2009 - "Comparative proteome analysis of TGF-beta1-induced fibrosis processes in normal rat kidney interstitial fibroblast cells in response to ascofuranone."