apocodeine

monomethyl ether of apomorphine; used as expectorant, hypnotic, & cathartic; RN refers to (R)-isomer; structure

Also Known As:

apocodeine hydrochloride, (R)-isomer; apocodeine oxalate, (R)-isomer

Networked: 4 relevant articles (0 outcomes, 1 trials/studies)

1.	Parkinson Disease (Parkinson's Disease) 05/01/1998 - "The pharmacokinetics and metabolism of R-apomorphine were determined in 10 patients with idiopathic Parkinson's disease after intravenous infusion of 30 micrograms.kg-1 in 15 min. Specifically, emphasis was on enantiomeric interconversion into S-apomorphine and on the formation of apocodeine and isoapocodeine, since these metabolites may interfere with the pharmacodynamics of R-apomorphine. " 05/01/1998 - "The findings of this study show that on intravenous administration, S-apomorphine and the metabolites apocodeine and isoapocodeine are unlikely to interfere with the pharmacologic actions of R-apomorphine in patients with idiopathic Parkinson's disease. " 11/21/1997 - "Assay of R-apomorphine, S-apomorphine, apocodeine, isoapocodeine and their glucuronide and sulfate conjugates in plasma and urine of patients with Parkinson's disease."
2.	Chronic Bronchitis 02/28/1891 - "On the Action of Apomorphine and Apocodeine, with Reference to their Value as Expectorants in the Treatment of Chronic Bronchitis."
3.	Paralysis (Palsy) 11/02/1903 - "The paralysis of nerve cells and nerve endings with special reference to the alkaloid apocodeine."

1.	Apomorphine
2.	isoapocodeine
3.	Pharmacologic Actions
4.	Glucuronides
5.	Sulfates (Sulfates, Inorganic)
6.	Expectorants (Mucolytics)
7.	Alkaloids

1.	Intravenous Administration
2.	Intravenous Infusions