|1.||Bova, G Steven: 1 article (02/2006)|
|2.||Helenius, Merja A: 1 article (02/2006)|
|3.||Savinainen, Kimmo J: 1 article (02/2006)|
|4.||Visakorpi, Tapio: 1 article (02/2006)|
|5.||Groves, Richard W: 1 article (12/2002)|
|6.||Daniel, Richard J: 1 article (12/2002)|
|1.||Prostatic Neoplasms (Prostate Cancer)
08/01/1998 - "Indeed, antibodies against uPA A-chain (and also p-aminobenzamidine treatment) interfere with the ATF domain and inhibit cell growth in uPA-producing PC3 and DU145 prostate cancer cell lines, whereas exogenous uPA (HMW-uPA with ATF) induces growth of LNCaP prostate tumor cell line. "
02/01/2006 - "Matrigel invasion assays with two specific uPA inhibitors, B428 and p-aminobenzamidine, showed that invasion of a prostate cancer cell line containing uPA gene amplification was inhibited by these small-molecule uPA inhibitors, while invasion of prostate cell lines without uPA gene amplification were not. "
05/16/1995 - "In conclusion, we show that a low-molecular-weight uPA-inhibitor, p-aminobenzamidine, has a growth-inhibitory effect on a solid uPA-producing tumor."
05/16/1995 - "Mice receiving 250 mg/kg/day of p-aminobenzamidine showed a clear decrease in tumor-growth rate compared to the non-treated mice, resulting in 64% lower final tumor weight. "
05/16/1995 - "in SCID mice and, once tumors were established, treatment with p-aminobenzamidine added to drinking water was started and lasted for 23 days. "
05/16/1995 - "In addition, uPA-antigen levels in the membrane fractions of DU 145 tumors from p-aminobenzamidine-treated mice were found to be decreased by 59%. "
05/16/1995 - "The urokinase inhibitor p-aminobenzamidine inhibits growth of a human prostate tumor in SCID mice."
05/01/1982 - "The effect of p-aminobenzamidine (pAB), an inhibitor of mouse sperm acrosin, on mouse sperm capacitation, motility, acrosome loss and fertility in vitro was examined using zona-intact and zona-free eggs. "
11/01/1998 - "This indicates that there is a p-aminobenzamidine-sensitive protease(s) other than acrosin participating in the zona penetration step. "
09/12/1997 - "Interaction of each activated mutant with an active site probe, p-aminobenzamidine, was also examined; the Kd of interaction in the absence and presence (in parentheses) of Ca2+ was: IXaNP or IXaWT 230 microM (78 microM), IXaE235K 150 microM (145 microM), IXaE245V 225 microM (240 microM), and autolysis loop cleaved IXaE245V 330 microM (350 microM). "
08/29/1997 - "Des-44-Xa in which the autolysis loop was cleaved possessed </=5% of the amidolytic activity of the noncleaved form; however, the S1 binding site was not affected, as determined by the p-aminobenzamidine binding. "
|5.||Wounds and Injuries (Trauma)
|1.||Urokinase-Type Plasminogen Activator (Urokinase)
|5.||Serine Proteases (Serine Protease)
|9.||Plasminogen Activators (Plasminogen Activator)