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jatrophone

RN refers to (2R-(2R*,3aR*,9E,12Z))-isomer; structure

Also Known As:

2,3,7,8-tetrahydro-2,5,8,8,12-pentamethyl-3 alpha, 6-epoxy-3 alphaH-cyclopentacyclododecin-4,11-dione

Networked: 7 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Terpenes: 1461
    - Diterpenes: 1470
      - jatrophone: 7

Experts

1.	Bryja, Vitezslav: 2 articles (01/2018 - 01/2017)
2.	El-Ayachi, Ikbale: 2 articles (01/2018 - 01/2017)
3.	Fatima, Iram: 2 articles (01/2018 - 01/2017)
4.	Hutnan, Miroslav: 2 articles (01/2018 - 01/2017)
5.	Krum, Susan A: 2 articles (01/2018 - 01/2017)
6.	Krutilina, Raisa I: 2 articles (01/2018 - 01/2017)
7.	Miranda-Carboni, Gustavo A: 2 articles (01/2018 - 01/2017)
8.	Radaszkiewicz, Tomasz W: 2 articles (01/2018 - 01/2017)
9.	Rivas, Fatima: 2 articles (01/2018 - 01/2017)
10.	Seagroves, Tiffany N: 2 articles (01/2018 - 01/2017)

Related Diseases

1.	Respiratory Syncytial Virus Infections 08/01/2020 - "The present study investigated anti-viral and anti-inflammatory activities of jatrophone against RSV-infection in pulmonary epithelial cells in vitro and in mice model in vivo. " 08/01/2020 - "The cytopathogenic changes by RSV infection were prevented and viral growth inhibited by jatrophone in BEAS-2B cells. "
2.	Breast Neoplasms (Breast Cancer) 08/22/2023 - "However, it is unclear whether jatrophone can overcome drug resistance in breast cancer. " 08/22/2023 - "This study includes the investigation of the cytotoxicity of jatrophone on doxorubicin-resistant breast cancer cells (MCF-7ADR) and the underlying molecular mechanisms. " 08/22/2023 - "Jatrophone: a cytotoxic macrocylic diterpene targeting PI3K/AKT/NF-κB pathway, inducing apoptosis and autophagy in resistant breast cancer cells." 08/22/2023 - "These findings provide evidence of the potential of jatrophone to be a promising lead compound for targeting doxorubicin-resistant breast cancer cells and could be further investigated for its clinical application as a chemotherapy adjuvant."
3.	Triple Negative Breast Neoplasms 01/01/2018 - "Correction: The natural compound Jatrophone interferes with Wnt/β-catenin signaling and inhibits proliferation and EMT in human triple-negative breast cancer." 01/01/2017 - "These results indicate that Jatrophone could be a powerful new chemotherapeutic agent against highly chemoresistant triple negative breast cancers by targeting the oncogenic Wnt10b/β-catenin signaling pathway." 01/01/2017 - "The natural compound Jatrophone interferes with Wnt/β-catenin signaling and inhibits proliferation and EMT in human triple-negative breast cancer."
4.	Neoplasms (Cancer) 04/14/1976 - "Structure and stereochemistry of jatrophone, a novel macrocyclic diterpenoid tumor inhibitor." 11/15/1973 - "Reaction of biological thiols with the tumor inhibitor jatrophone. "
5.	Virus Diseases (Viral Diseases) 08/01/2020 - "In RSV infected mice jatrophone increased immunity for viral infection by modulating cell phenotype for promotion of anti-viral IFN-γ. "

Related Drugs and Biologics

1.	Doxorubicin (Adriamycin)
2.	Catenins
3.	Diterpenes
4.	Sulfhydryl Compounds (Thiols)
5.	Interferons

Related Therapies and Procedures

1.	Adjuvant Chemotherapy