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FPL 55712

inhibitor of SRS-A and LTC4 and LTD4 receptors; structure
Also Known As:
FPL-55712; 7-((3-(4-acetyl-3-hydroxy-2-propylphenoxy)-2-hydroxypropoxyl))-4-oxo-8-propyl-4H-chromene-2-carboxy late, sodium salt
Networked: 50 relevant articles (4 outcomes, 4 trials/studies)

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Bio-Agent Context: Research Results

Related Diseases

1. Anaphylaxis (Anaphylactic Shock)
2. Anoxia (Hypoxia)
05/01/1987 - "In addition, the pressor response to whole-lung hypoxia was not blocked by an FPL-55712 infusion. "
09/01/1991 - "Enhancement of this anaphylactic mediator response was associated with an accentuated and prolonged increase of airway pressure (P less than 0.05, compared with sensitized, antigen-challenged but otherwise untreated sheep), a more intense hypoxemia (P less than 0.0001), and leukopenia (P less than 0.001), changes that were largely eliminated by pretreating with the sulfidopeptide leukotriene (SPLT) antagonist FPL 55712, suggesting that the SPLTs were important mediators of these responses. "
05/01/1984 - "FPL 55712, a leukotriene end-organ blocker, in a dose which inhibited vasoconstriction caused by exogenous leukotriene C4, inhibited the pressor response to hypoxia but not to angiotensin II. We conclude that leukotriene inhibitors preferentially inhibit hypoxic pulmonary vasoconstriction in isolated perfused adult rat lungs."
01/01/1992 - "The arteries were contracted by hypoxia (PO2 43 +/- 2 Torr) developing a tension of 127 +/- 36 mg over the course of 15 min. This contraction was completely blocked by 10(-6) M L-isoproterenol, 10(-6) M nitroglycerin, partially blocked by 10(-8)-10(-6) M verapamil, unchanged by 10(-6) M phentolamine, 10(-6) M L-propranolol, 10(-6) M diphenhydramine, 10(-6) M guanethidine, 10(-7) M FPL 55712 and enhanced by 10(-6) M BAY K 8644, 10(-3) M procaine, 3 x 10(-6) M quinacrine, 10(-6) M indomethacin or 10(-6) M methylene blue. "
3. Leukopenia
4. Weight Gain
5. Myocardial Ischemia (Ischemic Heart Diseases)

Related Drugs and Biologics

1. Leukotriene Receptors (Leukotriene Receptor)
2. SRS-A
3. Antigens
4. 4,5- Dihydro- 1- (3- (trifluoromethyl)phenyl)- 1H- pyrazol- 3- amine
5. Arachidonic Acid (Vitamin F)
6. 5,8,11,14-Eicosatetraynoic Acid (5,8,11,14 Eicosatetraynoic Acid)
7. Naloxone (Narcan)
8. Dexamethasone (Maxidex)
9. Phosgene
10. LY 171883

Related Therapies and Procedures

1. Vagotomy