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methodichlorophen

histamine methyltransferase antagonist
Also Known As:
2,4-diamino-5-(3',4'-dichlorophenyl)-6-methylpyrimidine; BW 1970; BW 50,197; DDMP; methodichlorophen hydrochloride; metoprine
Networked: 51 relevant articles (3 outcomes, 13 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Jochem, J: 4 articles (04/2005 - 03/2004)
2. Adachi, Naoto: 2 articles (03/2007 - 12/2005)
3. Arai, Tatsuru: 2 articles (03/2007 - 12/2005)
4. Liu, Keyue: 2 articles (03/2007 - 12/2005)
5. Kamei, C: 2 articles (10/2001 - 05/2001)
6. Guo, Lin: 1 article (01/2013)
7. Ding, Wence: 1 article (01/2013)
8. Kuznetsova, Galina D: 1 article (08/2012)
9. Birioukova, Lidiya M: 1 article (08/2012)
10. Samotaeva, Irina S: 1 article (08/2012)

Related Diseases

1. Seizures (Seizure)
2. Brain Infarction
3. Hypotension (Low Blood Pressure)
04/01/2005 - "The role of peripherally acting histamine in metoprine-induced reversal of haemorrhagic hypotension in rats--skeletal muscle microcirculatory studies."
04/01/2004 - "Experiments were carried out in ethylurethane-anaesthetised male Wistar rats subjected to haemorrhagic hypotension (mean arterial pressure MAP 20-25 mmHg), which led to the death of all control animals within 30 min. The HNMT inhibitor metoprine (20 micro g; i.c.v.) administered 5 min after establishing the critical hypotension increased the endogenous histamine concentration, measured 20 min after treatment, in the hypothalamus (534.33+/-67.52 vs. 423.98+/-54.17 ng/g wet tissue; P<0.05) and medulla oblongata (53.12+/-9.78 vs. 39.58+/-11.16 ng/g wet tissue; P<0.05). "
07/01/2004 - "The increase in central histamine concentrations after inhibition of histamine N-methyltransferase (HNMT) activity is associated with the reversal of critical haemorrhagic hypotension, therefore the present study examines cardiac and regional haemodynamic effects of HNMT inhibitor metoprine in haemorrhage-shocked rats. "
03/01/2004 - "Histamine N-methyltransferase inhibitor metoprine (20 microg) administered intracerebroventricularly at 5 min of critical hypotension 20-25 mmHg produced increases in histamine concentrations as measured 20 min after treatment in the hypothalamus (581.33 +/- 63.23 vs. 488.26 +/- 56.34 ng/g of wet tissue; P < 0.01) and medulla oblongata (53.42 +/- 14.65 vs. 34.68 +/- 13.52 ng/g of wet tissue; P < 0.05). "
03/01/2004 - "In the present study, the involvement of proopiomelanocortin (POMC)-derived peptides in central histamine-induced resuscitating action was examined in male anaesthetised Wistar rats subjected to a haemorrhagic hypotension of 20-25 mmHg resulting in the death of all control animals within 30 min. HNMT inhibitor metoprine (20 microg) administered intracerebroventricularly (i.c.v.) at 5 min of critical hypotension produced a long-lasting pressor effect with a 100% survival rate at 2 h. "
4. Neoplasms (Cancer)
5. Colorectal Neoplasms (Colorectal Cancer)

Related Drugs and Biologics

1. thioperamide
2. Histidine (L-Histidine)
3. Histamine (Histamine Dihydrochloride)
4. methodichlorophen
5. Leucovorin (Folinic Acid)
6. Folic Acid (Vitamin M)
7. Trimetrexate (JB11)
8. Methotrexate (Mexate)
9. Histamine N-Methyltransferase
10. Folic Acid Antagonists

Related Therapies and Procedures

1. Drug Therapy (Chemotherapy)
2. Aftercare (After-Treatment)
3. Injections