|1.||Jochem, J: 4 articles (04/2005 - 03/2004)|
|2.||Adachi, Naoto: 2 articles (03/2007 - 12/2005)|
|3.||Arai, Tatsuru: 2 articles (03/2007 - 12/2005)|
|4.||Liu, Keyue: 2 articles (03/2007 - 12/2005)|
|5.||Kamei, C: 2 articles (10/2001 - 05/2001)|
|6.||Guo, Lin: 1 article (01/2013)|
|7.||Ding, Wence: 1 article (01/2013)|
|8.||Kuznetsova, Galina D: 1 article (08/2012)|
|9.||Birioukova, Lidiya M: 1 article (08/2012)|
|10.||Samotaeva, Irina S: 1 article (08/2012)|
04/01/1987 - "Metoprine (20 mg/kg, i.p.) reduced the severity of seizures significantly 4 and 28 h after drug administration. "
04/01/1987 - "Inhibition of sound-induced convulsions by metoprine in the audiogenic seizure susceptible rat."
05/01/1978 - "The toxicity of DAMP and DAEP was charaxterized by convulsions followed by death; DDMP did not show such toxicity at median lethal doses. "
07/15/1998 - "Metoprine, an inhibitor of N-methyltransferase was also effective in inhibiting amygdaloid kindled seizure, and this effect was augmented by thioperamide treatment."
07/01/1992 - "Metoprine, which increased the histamine levels in the cerebral cortex, diencephalon and midbrain of mice, decreased the duration of clonic convulsions dose-dependently. "
12/20/2005 - "The combination treatment with thioperamide and metoprine decreased the size of brain infarction in rats given l-histidine (500 mg/kg), although protective effects were not clear without l-histidine. "
12/20/2005 - "Administration of l-histidine (1000 mg/kg) with either thioperamide (5 mg/kg) or metoprine (10 mg/kg) alleviated brain infarction. "
|3.||Hypotension (Low Blood Pressure)
04/01/2005 - "The role of peripherally acting histamine in metoprine-induced reversal of haemorrhagic hypotension in rats--skeletal muscle microcirculatory studies."
04/01/2004 - "Experiments were carried out in ethylurethane-anaesthetised male Wistar rats subjected to haemorrhagic hypotension (mean arterial pressure MAP 20-25 mmHg), which led to the death of all control animals within 30 min. The HNMT inhibitor metoprine (20 micro g; i.c.v.) administered 5 min after establishing the critical hypotension increased the endogenous histamine concentration, measured 20 min after treatment, in the hypothalamus (534.33+/-67.52 vs. 423.98+/-54.17 ng/g wet tissue; P<0.05) and medulla oblongata (53.12+/-9.78 vs. 39.58+/-11.16 ng/g wet tissue; P<0.05). "
07/01/2004 - "The increase in central histamine concentrations after inhibition of histamine N-methyltransferase (HNMT) activity is associated with the reversal of critical haemorrhagic hypotension, therefore the present study examines cardiac and regional haemodynamic effects of HNMT inhibitor metoprine in haemorrhage-shocked rats. "
03/01/2004 - "Histamine N-methyltransferase inhibitor metoprine (20 microg) administered intracerebroventricularly at 5 min of critical hypotension 20-25 mmHg produced increases in histamine concentrations as measured 20 min after treatment in the hypothalamus (581.33 +/- 63.23 vs. 488.26 +/- 56.34 ng/g of wet tissue; P < 0.01) and medulla oblongata (53.42 +/- 14.65 vs. 34.68 +/- 13.52 ng/g of wet tissue; P < 0.05). "
03/01/2004 - "In the present study, the involvement of proopiomelanocortin (POMC)-derived peptides in central histamine-induced resuscitating action was examined in male anaesthetised Wistar rats subjected to a haemorrhagic hypotension of 20-25 mmHg resulting in the death of all control animals within 30 min. HNMT inhibitor metoprine (20 microg) administered intracerebroventricularly (i.c.v.) at 5 min of critical hypotension produced a long-lasting pressor effect with a 100% survival rate at 2 h. "
08/01/1980 - "Phase I trial of metoprine in patients with advanced cancer."
01/01/2013 - "Compared with DOX-coupled DMP without Tf modification (DDMP), TfDMP exhibits enhanced uptake by Tf receptor-expressing tumor cells, and displays stronger cancer cell cytotoxicity. "
08/01/1980 - "The effects of metoprine administered orally every 2 weeks were studied in 71 evaluable adult patients with advanced malignant tumors. "
09/01/1979 - "However, CPDG1 (800 units/kg/day) from Day 1 to Day 6 in combination with TZT (0.05 mg/kg on Day 1) or DDMP (15 mg/kg on Days 1, 3, and 5) resulted in increases of 50 and 30%, respectively, in the survival of the tumor-bearing animals. "
03/01/1982 - "The M5076 murine "ovarian" tumor which is naturally refractive to methotrexate was found to be highly responsive to the lipophilic antifolate, metoprine. "
|5.||Colorectal Neoplasms (Colorectal Cancer)
01/01/1981 - "Phase II evaluation of metoprine in patients with advanced colorectal carcinoma."
01/01/1981 - "High-dose metoprine with leucovorin rescue appears ineffective in previously treated patients with colorectal carcinoma in the dose and schedule used in this study."
01/01/1981 - "In a phase II trial 24 patients with measurable metastatic colorectal carcinoma were treated every 2 weeks with high-dose metoprine at 175 mg/m2 and leucovorin rescue. "
01/01/1981 - "Phase II evaluation of metoprine with leucovorin rescue in patients with advanced colorectal carcinoma."
|3.||Histamine (Histamine Dihydrochloride)
|5.||Leucovorin (Folinic Acid)
|6.||Folic Acid (Vitamin M)
|10.||Folic Acid Antagonists
|1.||Drug Therapy (Chemotherapy)