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actodigin
structure
Also Known As:
3 beta-D-glucopyranosyl-14 beta,24-dihydroxy-21,23-bisnor-5 beta-chol-20(22)-ene-20-carboxylic acid gamma-lactone; AY 22,241; Actinogen
Networked:
6
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Polycyclic Compounds: 6
Fused-Ring Compounds
Steroids: 70059
Cardanolides
Cardiac Glycosides: 1002
Cardenolides: 137
actodigin: 6
Related Diseases
1.
Cardiac Arrhythmias (Arrythmia)
03/01/1977 - "
Upon termination of the actodigin infusion, the arrhythmia spontaneously converted to sinus rhythm within 17.5 +/- 2.3 min. Left ventricular tissue was taken from dogs sacrificed at the peak of the actodigin-induced arrhythmic periods or from the dogs that were allowed to recover from the actodigin-induced arrhythmia.
"
03/01/1977 - "
An infusion of actodigin(AY22,241) at the rate of 0.1 micronmol/kg/min for 30 min induced a severe and persistent arrhythmia within 13.1 +/- 192 min of 9 dogs.
"
07/01/1977 - "
Both actodigin and ouabain converted this arrhythmia to normal sinus rhythm.
"
04/01/1977 - "
However, in animals in which the infusion of drug was stopped one minute after the onset of ventricular tachycardia, the arrhythmia terminated sooner in cats given actodigin than in those given ouabain.
"
03/01/1977 - "
In order to determine if there is a relationship between Na+, K+-ATPase inhibition and cardiac glycoside-induced arrhythmia, the time course of the onset and offset of the arrhythmia induced by the semi-synthetic glycoside, actodigin, and the enzyme activity during arrhythmia and following reversion to normal sinus rhythm was studied in the intact, anethetized dog.
"
2.
Heart Failure
09/01/1977 - "
Five patients with congestive heart failure in normal sinus rhythm were given incremental doses of actodigin.
"
07/01/1977 - "
When injected at 30 min invervals into dogs with barbiturate-induced heart failure, actodigin caused a marked positive inotropic action of short duration.
"
3.
Atrial Fibrillation
09/01/1977 - "
Thus, the rapid onset and brief duration of action of actodigin may be useful in the initial management of atrial fibrillation.
"
09/01/1977 - "
Four patients with atrial fibrillation and a rapid ventricular rate were given similar doses of actodigin.
"
07/01/1974 - "
[Action of actodigin (AY-22,241) in patients with cardiac insufficiency and chronic auricular fibrillation or flutter].
"
4.
Ventricular Premature Complexes (Premature Ventricular Contraction)
05/01/1975 - "
Purkinje fibers superfused with extracorporeally circulated blood from a donor dog receiving 0.075 mg/kg/min Actodigin showed small decreases in resting membrane potential preceding the onset of donor premature ventricular contractions.
"
5.
Ventricular Tachycardia
04/01/1977 - "
Actodigin-induced ventricular tachycardia occurred sooner than that induced by ouabain.
"
04/01/1977 - "
However, in animals in which the infusion of drug was stopped one minute after the onset of ventricular tachycardia, the arrhythmia terminated sooner in cats given actodigin than in those given ouabain.
"
Related Drugs and Biologics
1.
Ouabain (G Strophanthin)
2.
Glycosides
3.
Enzymes
4.
Cardiac Glycosides
5.
Adenosine Triphosphatases (ATPase)
6.
barbituric acid (barbiturate)