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R388 (R-factor)

drug-resistant form of enzyme, dihydrofolate reductase, biosynthesized by E coli that confers resistance to trimethoprim; increases resistance by 10,000 fold & mediates synthesis of additional dihydrofolate reductase which is 20,000x less susceptible to trimethoprim inhibition; do not confuse with Cat. G heading R FACTORS
Also Known As:
R-factor; R 388; R-388
Networked: 69 relevant articles (2 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Schry, Amie R: 1 article (05/2014)
2. White, Susan W: 1 article (05/2014)
3. Smith, Laura A: 1 article (05/2014)
4. Yamada, Shozo: 1 article (04/2014)
5. Nakano-Tateno, Tae: 1 article (04/2014)
6. Hlaing, Maw Maw: 1 article (04/2014)
7. Yoshimoto, Katsuhiko: 1 article (04/2014)
8. Zheng, Lei: 1 article (04/2014)
9. Asa, Sylvia L: 1 article (04/2014)
10. Tateno, Toru: 1 article (04/2014)

Related Diseases

1. Starvation
2. Dysentery
3. Urinary Tract Infections (Urinary Tract Infection)
4. Infection
5. Superinfection

Related Drugs and Biologics

1. Thymine
2. Trimethoprim (Proloprim)
3. Chloramphenicol (Chloromycetin)
4. Ampicillin (Omnipen)
5. DNA (Deoxyribonucleic Acid)
6. Streptomycin (Streptomycin Sulfate)
7. Kanamycin
8. Gentamicins (Gentamicin)
9. Antigens
10. Tetracycline (Achromycin)

Related Therapies and Procedures

1. Catheters
2. Refractive Surgical Procedures
3. Intensive Care (Surgical Intensive Care)
4. Intraocular Lenses (Intraocular Lens)
5. Drug Therapy (Chemotherapy)