RC-12 (RC 12)

RN given refers to parent cpd; structure

Also Known As:

RC 12; 1,2-dimethoxy-4-bis(diethylaminoethyl)amino-5-bromobenzene; 4-(2-bromo-4,5-dimethoxyphenyl)-1,1,7,7-tetraethyldiethylenetriamine; RC-12 naphthalenedisulfonate; N-(2-bromo-4,5-dimethoxyphenyl)-N-(2-(diethylamino)ethyl)-N',N'-diethyl-1,2-ethanediamine

Networked: 5 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amines: 4871
  - Polyamines: 3918
    - Diamines: 518
      - Ethylenediamines: 7
        RC-12: 5

Experts

1.	Chen, Tianfeng: 1 article (04/2018)
2.	Fang, Xueyang: 1 article (04/2018)
3.	Li, Chang'e: 1 article (04/2018)
4.	Yang, Fang: 1 article (04/2018)
5.	Zheng, Lan: 1 article (04/2018)

Related Diseases

1.	Neoplasms (Cancer) 04/16/2018 - "Hence, to assure that the chemotherapeutic drug and photothermal agent are synchronously delivered to a tumor area for their synergistic effect, dual-target (RC-12 and PG-6 peptides) functionalized selenium nanoparticles loaded with both doxorubicin (DOX) and indocyanine green (ICG) were designed and successfully synthesized. "
2.	Monosomy 04/15/1998 - "Twenty-seven cases had clonal abnormalities by routine cytogenetics (RC): 12 with monosomy 7; one with monosomy 8; five with trisomy 8; nine with clonal abnormalities other than 7 or 8 aneuploidy. "
3.	Malaria 01/01/1972 - "The compound 4-(2-bromo-4,5-dimethoxyphenyl)-1,1,7,7-tetraethyldiethylenetriamine (RC-12) has been shown to be active against the exoerythrocytic (EE) stages of the malaria parasite. "
4.	Infections 11/01/1985 - "In such appraisals, daily doses of 6.25 to 25.0 mg of RC-12 per kg for 14 days, in combination with 2.5 mg of chloroquine per kg daily for 7 days, effected cure of 69 and 93% of established infections, respectively. " 11/01/1985 - "RC-12 [1,2-dimethoxy-4-(bis-diethylaminoethyl)-amino-5-bromobenzene] was evaluated for prophylactic, radical curative, and suppressive activities against infections with Plasmodium cynomolgi and subacute toxicity in rhesus monkeys. "
5.	Confusion (Bewilderment) 02/01/2015 - "L’âge (rapport des cotes [RC] 1,08 par palier) et un séjour préopératoire à l’USI (RC 12) ont été significativement associés à la mortalité perhospitalière après contrôle des facteurs de confusion, mais non l’IMC. "

Related Drugs and Biologics

1.	Selenium
2.	Peptides (Polypeptides)
3.	Indocyanine Green (Cardio-Green)
4.	Doxorubicin (Adriamycin)
5.	Chloroquine (Aralen)
6.	bromobenzene