|1.||van Loveren, Henk: 9 articles (12/2014 - 12/2006)|
|2.||Osman, Ahmed M: 4 articles (12/2014 - 09/2009)|
|3.||Pennings, Jeroen L A: 4 articles (09/2009 - 12/2006)|
|4.||Baken, Kirsten A: 3 articles (01/2008 - 12/2006)|
|5.||Peijnenburg, Ad: 2 articles (06/2012 - 09/2009)|
|6.||Harino, Hiroya: 2 articles (04/2010 - 04/2009)|
|7.||Wester, P W: 2 articles (10/2009 - 03/2000)|
|8.||Vethaak, A D: 2 articles (10/2009 - 03/2000)|
|9.||van Steeg, Harry: 2 articles (01/2008 - 12/2006)|
|10.||de Vries, Annemieke: 2 articles (01/2008 - 12/2006)|
|1.||Body Weight (Weight, Body)
02/01/1990 - "At the highest dose TBTO caused a significant reduction of maternal body weight gain and also proved to be highly embryotoxic. "
04/01/2010 - "A tolerable average residue level (TARL) was estimated at 74.8 microg kg(-1) from a tolerable daily intake (TDI) of 0.25 bis(tributyltin)oxide microg kg(-1) body weight day(-1). "
04/01/2009 - "A tolerable average residue level (TARL) was estimated at 20.4 microg/kg from a tolerable daily intake (TDI) of 0.25 microg TBTO/kg body weight/day. "
01/01/2008 - "TBTO exposure caused the most pronounced effect on gene expression and also resulted in the most severe reduction of body weight gain and induction of splenic irregularities. "
01/01/1998 - "The no-effect level assessed by estimating effects on host resistance in rats has been found to lie between 0.5 and 5.0 mg TBTO/kg food (0.025 and 0.25 mg/kg body weight). "
12/01/2006 - "TBTO causes thymus atrophy and thereby interferes with T-lymphocyte-mediated immune responses. "
07/01/1999 - "Furthermore, the data obtained suggest that antiproliferative effects may be more relevant than apoptosis induction for TBTO induced thymus atrophy."
12/01/1991 - "Histological examination of the thymus of rats treated for 7 days with TBTO showed atrophy with severe lymphocytic depletion in the cortex. "
11/01/1980 - "TBTO at a a single dose of 100 mg/kg, or a total dose of 390 to 780 mg/kg in 13 weeks, or 780 to 1,560 mg/kg in 26 weeks, caused adrenal hypertrophy, flattening of the thyroid epithelium and atrophy of the thymus and lymph nodes. "
06/14/2012 - "The biocide bis(tri-n-butyltin)oxide (TBTO) causes thymus atrophy in rodents and is toxic to many cell types of which thymocytes are the most sensitive. "
05/15/1989 - "Tributyltin oxide at 5 ppm in the rat diet produced immunotoxicity in a 2-year feeding study, and at 50 ppm increased the incidence of tumors of endocrine origin. "
05/01/2004 - "Methylmercury poisoning (e.g., Minamata disease) and tumor development in rats after exposure to dimethylarsinic acid or tributyltin oxide are just some examples. "
09/30/1984 - "To evaluate the functional significance of bis(tri-n-butyltin)oxide (TBTO)-induced thymus atrophy, lymphocyte depletion in spleen and lymph nodes, lymphopenia, and increased serum IgM and decreased IgG concentrations, in vivo and in vitro function studies were performed for specific and nonspecific resistance. "
|1.||bis(tri-n-butyltin)oxide (tributyltin oxide)
|3.||Immunoglobulin M (IgM)
|4.||Immunoglobulin G (IgG)
|8.||Eukaryotic Initiation Factor-4E
|9.||RNA Cap-Binding Proteins (Cap Binding Protein)
|1.||Blood Transfusion (Blood Transfusions)