muconic acid (cis,cis-muconate)

a metabolite of benzene; reported to be a reliable indicator of occupational exposure to benzene; structure given in first source

Also Known As:

cis,cis-muconate; muconic acid, (E,E)-isomer; trans,trans-muconic acid; trans-beta-hydromuconic acid; 2,4-hexadienedioic acid

Networked: 11 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Lipids: 114793
- Fatty Acids: 27405
  - Unsaturated Fatty Acids: 8236
    - Sorbic Acid: 64
      - muconic acid: 11

Experts

1.	Alves, Sérgio R: 1 article (01/2019)
2.	André, Leiliane C: 1 article (01/2019)
3.	Borges, Renato M: 1 article (01/2019)
4.	Carvalho, Leandro V B: 1 article (01/2019)
5.	Castro, Vinicio S: 1 article (01/2019)
6.	Collins, Andrew R: 1 article (01/2019)
7.	Costa-Amaral, Isabele C: 1 article (01/2019)
8.	Figueiredo, Victor O: 1 article (01/2019)
9.	Fonseca, Antônio Sérgio A: 1 article (01/2019)
10.	Gonçalves, Eline S: 1 article (01/2019)

Related Diseases

1.	Chromosome Aberrations (Chromosome Abnormalities) 01/15/2010 - "End-shift urine samples were collected for t,t-muconic acid (t,t-MA) determination by HPLC and for S-phenylmercapturic acid (S-PMA) measurement by HPLC-MS/MS. The alkaline version of the comet assay and, in a subgroup of 19 SSA and 16 control subjects, chromosomal aberrations (CA) and glutathione (GSH) levels were measured in peripheral blood lymphocytes. " 02/10/2009 - "In the present study, in vitro genotoxicity of benzene (BZ) and its major metabolites [p-benzoquinone (BQ), hydroquinone (HQ), catechol (CT), 1,2,4-benzenetriol (BT) and trans-trans muconic acid (MA)] at concentrations 0.5-50 microM, was assessed in Chinese hamster ovary (CHO) cells employing the alkaline Comet assay, cytokinesis blocked micronucleus (CBMN) assay, flow cytometric analysis of micronucleus (flow MN) and chromosome aberration (CA) test. " 06/01/2003 - "The biomarkers evaluated were urinary metabolites S-phenylmercapturic acid (S-PMA*), trans,trans-muconic acid (t,t-MA), hydroquinone (HQ), catechol (CAT), and phenol; albumin adducts of benzene oxide and 1,4-benzoquinone (BO-Alb and 1,4-BQ-Alb, respectively) in blood; blood cell counts; and chromosomal aberrations. " 01/01/2019 - "Sociodemographic data on the workers were evaluated; the concentration of benzene/toluene (B/T) in atmospheric air and individual trans,trans-muconic acid (ttMA) and S-phenylmercapturic acid (S-PMA) were measured; oxidative stress was analyzed by catalase (CAT), glutathione S-transferase (GST), superoxide dismutase (SOD), thiol groups (THIOL) and malondialdehyde (MDA); genotoxicity was measured by metaphases with chromosomal abnormalities (MCA) and nuclear abnormalities, comet assay using the enzyme formamidopyrimidine DNA glycosylase (C-FPG), and methylation of repetitive element LINE-1, CDKN2B and KLF6 genes. "
2.	Nervous System Diseases (Neurological Disorders) 01/01/2023 - "The results of the analysis of the relationship between t,t-muconic acid concentrations classified by 3 levels of percentile and neurological disorders of the study group, the results showed that there was a statistically significant relationship (p-value <0.05). "
3.	Insulin Resistance 12/01/2018 - "The aim of this study is to investigate the association between urinary benzene metabolite, trans, trans-muconic acid (t,t-ma) and markers of oxidative stress and insulin resistance in children and adolescents. "
4.	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 01/01/1993 - "Since chronic benzene exposure causes acute myeloid leukemia in humans, we aimed to determine the uptake and metabolic activation of benzene from cigarette smoke in smokers by measuring the levels of the urinary benzene metabolite, trans,trans-muconic acid (t,t-MA). "
5.	Neoplasms (Cancer) 01/01/2017 - "Urinary trans,trans-muconic acid levels, well-known genetic and hematological alterations linked to benzene exposure, and non-cancer effects on the immune, hepatic, and renal systems were investigated. "

Related Drugs and Biologics

1.	Benzene (Benzole)
2.	catechol (pyrocatechol)
3.	hydroquinone (Esoterica)
4.	quinone (benzoquinone)
5.	hydroxyhydroquinone (hydroxyquinol)
6.	S-phenyl-N-acetylcysteine
7.	Polyphenols
8.	DNA-Formamidopyrimidine Glycosylase (Formamidopyrimidine DNA Glycosylase)
9.	Phenol (Carbolic Acid)
10.	Biomarkers (Surrogate Marker)