Allura Red AC Dye (FD & C red no. 40)

new monoazo dye proposed as color additive in various food products; RN given refers to di-Na salt; structure

Also Known As:

FD & C red no. 40; C.I. 16035; F D & C red #40; R-40; allura red; disodium 6-hydroxy-5-((2-methoxy-5-methyl-4-sulfonatophenyl)diazenyl)naphthalene-2-sulfonate

Networked: 14 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Azo Compounds: 333
  - Allura Red AC Dye: 14

Experts

1.	Bradman, Asa: 2 articles (03/2022 - 09/2020)
2.	Miller, Mark D: 2 articles (03/2022 - 09/2020)
3.	Castorina, Rosemary: 1 article (03/2022)
4.	Gillan, Mayela: 1 article (03/2022)
5.	Han, Dorothy: 1 article (03/2022)
6.	Lehmkuhler, Arlie: 1 article (03/2022)
7.	Marty, Melanie: 1 article (03/2022)
8.	Mitchell, Alyson: 1 article (03/2022)
9.	Nirula, Anuroop: 1 article (03/2022)
10.	Pattabhiraman, Teja: 1 article (03/2022)

Related Diseases

1.	Body Weight (Weight, Body) 12/01/1989 - "The treated females consumed 273.6, 545.7, and 939.3 mg FD&C Red No. 40 per kg body weight per day, respectively, for the three dose levels. " 11/01/1989 - "Osborne-Mendel rats were intubated with FD & C Red No. 40 at dose levels of 0, 30, 75, 150, 300, 600, or 1000 mg/kg body weight/day on days 0-19 of gestation. " 01/01/2018 - "Thirty adult male albino rats were divided into three groups of 10 animals each: control (received water), Sunset Yellow-treated (2.5 mg/kg body weight) and Allura Red-treated (seven mg/kg body weight). "
2.	Neoplasms (Cancer) 06/01/2016 - "Between 2009 and 2015, an adipodermal gaft was used in 5 cases of craniofacial post-traumatic defects, 3 of which were due to Palacos R-40 cranial reconstruction and 2 connected to maxillofacial tumor removal and post-traumatic reconstruction. " 06/01/2016 - "In reconstruction of post-traumatic craniofacial defects Palacos R-40 is mostly used by neurosurgeons and by maxillofacial surgeons after tumor removal with consequently noticeable irregularities on the shape of the cranial region and face. " 01/01/2016 - "High consumption of Allura Red has claimed an adverse effects of human health including allergies, food intolerance, cancer, multiple sclerosis, attention deficit hyperactivity disorder, brain damage, nausea, cardiac disease and asthma due to the reaction of aromatic azo compounds (R = R' = aromatic). "
3.	Hypersensitivity (Allergy) 01/01/2023 - "The highest exposure was found for FD&C Red No. 40 in a children's cold/cough/allergy syrup. " 09/01/2020 - "Intake of FD&C Red No. 40 is two times the US FDA ADI (accepted daily intake) for some children's pain reliever syrups and almost three times the US FDA ADI for some cough/cold/allergy syrups." 09/01/2020 - "To address this, FD&C Red No. 40, Yellow No. 5, Yellow No. 6, Blue No. 1, and Blue No. 2 levels were measured in prenatal vitamin tablets, children's chewable and gummy vitamins, pain reliever tablets and syrups, and cough/cold/allergy tablets and syrups. "
4.	Cough 01/01/2023 - "The highest exposure was found for FD&C Red No. 40 in a children's cold/cough/allergy syrup. " 09/01/2020 - "Intake of FD&C Red No. 40 is two times the US FDA ADI (accepted daily intake) for some children's pain reliever syrups and almost three times the US FDA ADI for some cough/cold/allergy syrups." 09/01/2020 - "To address this, FD&C Red No. 40, Yellow No. 5, Yellow No. 6, Blue No. 1, and Blue No. 2 levels were measured in prenatal vitamin tablets, children's chewable and gummy vitamins, pain reliever tablets and syrups, and cough/cold/allergy tablets and syrups. "
5.	Colitis 12/20/2022 - "Allura Red AC (AR) is a highly common synthetic colorant; however, little is known about its impact on colitis. " 05/30/2023 - "Author Correction: Chronic exposure to synthetic food colorant Allura Red AC promotes susceptibility to experimental colitis via intestinal serotonin in mice." 12/20/2022 - "Chronic exposure to synthetic food colorant Allura Red AC promotes susceptibility to experimental colitis via intestinal serotonin in mice."

Related Drugs and Biologics

1.	Tartrazine
2.	Serotonin (5 Hydroxytryptamine)
3.	Coloring Agents (Dyes)
4.	Azo Compounds
5.	6-hydroxy-5-((p- sulfophenyl)azo)-2-naphthalenesulfonic acid disodium salt (Sunset yellow FCF)
6.	Vitamins
7.	Tablets
8.	Proteins (Proteins, Gene)
9.	Aluminum
10.	ponceau 4R (E 124)