methyl 4-mercaptobutyrimidate

used as a cross-linking agent to study ribosomal proteins, by making disulfide linkages; RN given refers to parent cpd; structure
Also Known As:
2-iminothiolane; methyl 4-mercaptobutyrimidate hydrochloride
Networked: 12 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results


1. Mishra, A K: 2 articles (12/2002 - 06/2000)
2. Tanaka, Kuniyoshi: 1 article (10/2009)
3. Shen, Xiaodong: 1 article (10/2009)
4. Takamori, Atsushi: 1 article (10/2009)
5. Yuan, Aina: 1 article (11/2006)
6. Richman, Carol M: 1 article (11/2006)
7. Shen, Sui: 1 article (11/2006)
8. DeNardo, Sally J: 1 article (11/2006)
9. DeNardo, Gerald L: 1 article (11/2006)
10. Lehmann, Joerg: 1 article (11/2006)

Related Diseases

1. Breast Neoplasms (Breast Cancer)
11/15/2006 - "111In-DOTA-glycylglycylglycyl-l-p-isothiocyanatophenylalanine amide (GGGF)-m170 and 111In-1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetic acid (DOTA) 2-iminothiolane (2IT)-m170, representing the same MAb and chelate with and without a cleavable linkage, were studied in 13 breast cancer and 26 prostate cancer patients. "
08/01/1985 - "When MCF-7 human breast cancer cells are incubated with [3H]estradiol or [3H]antiestrogen [alpha-[4-pyrrolidinoethoxy]phenyl-4-hydroxy-alpha'-nitrostilbe ne (CI628M) or (Z)-1-[4-(2-[N-aziridinyl]ethoxy)phenyl] 1,2-diphenyl-1-butene (tamoxifen aziridine)] and nuclear estrogen-receptor complexes are extracted with 0.6 M KCl and then chemically cross-linked with the cross-linker 2-iminothiolane, the cross-linked receptor complexes sediment as a 5.4S species on 3 M urea-containing sucrose gradients, while the noncross-linked species are 4S. "
12/01/2002 - "The following studies are described in this article: the 99mTc-randiolabeling of 2-iminothiolane (2-IT) modified antibodies and 6-p-isothiocyanatobenzyl- diethylene-triamine penta-acetic acid (CITC-DTPA) immunoconjugates of anti-EGF-receptor antibodies murine ior egf/r3 and humanized h-R3; the analytical methods for quality control of the radiopharmaceutical such as instant thin layer chromatography-silica gel (ITLC-SG); the biological assessment of the radiolabeled molecule using flow cytometry analysis; in vitro stability studies with cysteine and DTPA challenge and the biodistribution studies in 4NMRI xenografted nude mice with U-87 human glioblastoma multiforme and MDA-MB-468 breast cancer cell lines. "
2. Glioblastoma (Glioblastoma Multiforme)
3. Adenocarcinoma
4. Small Cell Lung Carcinoma (Small Cell Lung Cancer)
5. Osteosarcoma (Osteogenic Sarcoma)

Related Drugs and Biologics

1. Immunoconjugates (Immunoconjugate)
2. Antibodies
3. Silica Gel
4. Acetic Acid (Vinegar)
5. Epidermal Growth Factor Receptor (EGF Receptor)
6. Epidermal Growth Factor (EGF)
7. Pentetic Acid (DTPA)
8. Cysteine (L-Cysteine)
9. 6- (4- isothiocyanatobenzyl)- diethylenetriamine pentaacetic acid