methyl 4-mercaptobutyrimidate

used as a cross-linking agent to study ribosomal proteins, by making disulfide linkages; RN given refers to parent cpd; structure

Also Known As:

2-iminothiolane; methyl 4-mercaptobutyrimidate hydrochloride

Networked: 13 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Imides: 79
  - Imidoesters: 4
    - methyl 4-mercaptobutyrimidate: 13

Experts

1.	Mishra, A K: 2 articles (12/2002 - 06/2000)
2.	Li, Xinming: 1 article (09/2021)
3.	Liu, Peng: 1 article (09/2021)
4.	Zhang, Juan: 1 article (09/2021)
5.	Shen, Xiaodong: 1 article (10/2009)
6.	Takamori, Atsushi: 1 article (10/2009)
7.	Tanaka, Kuniyoshi: 1 article (10/2009)
8.	DeNardo, Gerald L: 1 article (11/2006)
9.	DeNardo, Sally J: 1 article (11/2006)
10.	Lehmann, Joerg: 1 article (11/2006)

Related Diseases

1.	Breast Neoplasms (Breast Cancer) 11/15/2006 - "111In-DOTA-glycylglycylglycyl-l-p-isothiocyanatophenylalanine amide (GGGF)-m170 and 111In-1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetic acid (DOTA) 2-iminothiolane (2IT)-m170, representing the same MAb and chelate with and without a cleavable linkage, were studied in 13 breast cancer and 26 prostate cancer patients. " 08/01/1985 - "When MCF-7 human breast cancer cells are incubated with [3H]estradiol or [3H]antiestrogen [alpha-[4-pyrrolidinoethoxy]phenyl-4-hydroxy-alpha'-nitrostilbe ne (CI628M) or (Z)-1-[4-(2-[N-aziridinyl]ethoxy)phenyl] 1,2-diphenyl-1-butene (tamoxifen aziridine)] and nuclear estrogen-receptor complexes are extracted with 0.6 M KCl and then chemically cross-linked with the cross-linker 2-iminothiolane, the cross-linked receptor complexes sediment as a 5.4S species on 3 M urea-containing sucrose gradients, while the noncross-linked species are 4S. " 12/01/2002 - "The following studies are described in this article: the 99mTc-randiolabeling of 2-iminothiolane (2-IT) modified antibodies and 6-p-isothiocyanatobenzyl- diethylene-triamine penta-acetic acid (CITC-DTPA) immunoconjugates of anti-EGF-receptor antibodies murine ior egf/r3 and humanized h-R3; the analytical methods for quality control of the radiopharmaceutical such as instant thin layer chromatography-silica gel (ITLC-SG); the biological assessment of the radiolabeled molecule using flow cytometry analysis; in vitro stability studies with cysteine and DTPA challenge and the biodistribution studies in 4NMRI xenografted nude mice with U-87 human glioblastoma multiforme and MDA-MB-468 breast cancer cell lines. "
2.	Glioblastoma (Glioblastoma Multiforme) 12/01/2002 - "The following studies are described in this article: the 99mTc-randiolabeling of 2-iminothiolane (2-IT) modified antibodies and 6-p-isothiocyanatobenzyl- diethylene-triamine penta-acetic acid (CITC-DTPA) immunoconjugates of anti-EGF-receptor antibodies murine ior egf/r3 and humanized h-R3; the analytical methods for quality control of the radiopharmaceutical such as instant thin layer chromatography-silica gel (ITLC-SG); the biological assessment of the radiolabeled molecule using flow cytometry analysis; in vitro stability studies with cysteine and DTPA challenge and the biodistribution studies in 4NMRI xenografted nude mice with U-87 human glioblastoma multiforme and MDA-MB-468 breast cancer cell lines. "
3.	Adenocarcinoma 09/01/2000 - "The monoclonal antibody MSN-1 (IgM), which reacts strongly with endometrial adenocarcinomas, was combined with adriamycin (ADM) by a disulfide bond using N-succinimidyl-3-(2-pyridyldithio) propionate (SPDP) and 2-iminothiolane. " 05/01/1998 - "We have developed an immunoconjugate consisting of the monoclonal antibody MSN-1 (IgM), which reacts strongly with endometrial adenocarcinomas, combined with a plant hemitoxin named gelonin via a disulfide bond using N-succinimidyl-3-(2-pyridyldithio) propionate and 2-iminothiolane, and examined its selective cytotoxicity in athymic mice. "
4.	Small Cell Lung Carcinoma (Small Cell Lung Cancer) 06/01/2000 - "We have evaluated the potential of 188Re-labeled monoclonal antibodies (MAbs) modified with 2-iminothiolane (2IT) for targeting small-cell lung cancer (SCLC). " 06/01/2000 - "Rhenium-188-labeled anti-neural cell adhesion molecule antibodies with 2-iminothiolane modification for targeting small-cell lung cancer."
5.	Osteosarcoma (Osteogenic Sarcoma) 01/01/1999 - "The amine residue of NH2-C3(BHam)2 was converted to a maleimide group by reaction with N-succinimidyl-6-maleimidohexanoate, and the conjugation product was coupled to thiol groups of a monoclonal antibody against osteogenic sarcoma (OST7, IgG1) pretreated with 2-iminothiolane to prepare C3(BHam)2-OST7. "

Related Drugs and Biologics

1.	Immunoconjugates (Immunoconjugate)
2.	Antibodies
3.	ErbB Receptors (EGF Receptor)
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5.	Acetic Acid (Vinegar)
6.	Radiopharmaceuticals
7.	Epidermal Growth Factor (EGF)
8.	Pentetic Acid (DTPA)
9.	Cysteine (L-Cysteine)
10.	6- (4- isothiocyanatobenzyl)- diethylenetriamine pentaacetic acid