|1.||Hazen, Stanley L: 18 articles (01/2016 - 04/2011)|
|2.||Wang, Zeneng: 15 articles (01/2016 - 04/2011)|
|3.||Tang, W H Wilson: 14 articles (01/2016 - 04/2011)|
|4.||Wu, Yuping: 9 articles (01/2016 - 04/2011)|
|5.||Levison, Bruce S: 9 articles (12/2015 - 04/2011)|
|6.||Lusis, Aldons J: 8 articles (12/2015 - 04/2011)|
|7.||Buffa, Jennifer A: 6 articles (12/2015 - 05/2013)|
|8.||Bennett, Brian J: 6 articles (02/2015 - 04/2011)|
|9.||DiDonato, Joseph A: 5 articles (12/2015 - 04/2011)|
|10.||Fu, Xiaoming: 5 articles (12/2015 - 04/2011)|
|1.||Cystic Fibrosis (Mucoviscidosis)
07/01/2001 - "This study was designed to test the in vivo efficacy of the chemical chaperone trimethylamine oxide (TMAO) in correcting the Cl- transport defect in a mouse model of cystic fibrosis (CF). "
07/01/1998 - "In vitro studies in transfected cells have indicated that chemical chaperones including glycerol (0.5-1.2 M) and trimethylamine oxide (TMAO, 50-100 mM) can correct defective trafficking of some proteins, including deltaF508 CFTR in cystic fibrosis and AQP2 mutants in nephrogenic diabetes insipidus. "
09/01/2014 - "We incubated RBCs in vitro with and without physiologically relevant concentrations of TMAO at 13°C and then exposed cells to a 1-h acute heat shock at 24°C. "
03/01/2009 - "Notably, serum-free established EBS-cell line was most vulnerable to heat shock but both cell lines exhibited significant reduction in the number of keratin aggregates containing cells by TMAO. "
02/01/2000 - "Microscopic stability of cold shock protein A examined by NMR native state hydrogen exchange as a function of urea and trimethylamine N-oxide."
02/01/2000 - "Native state hydrogen exchange of cold shock protein A (CspA) has been characterized as a function of the denaturant urea and of the stabilizing agent trimethylamine N-oxide (TMAO). "
|3.||Epidermolysis Bullosa Simplex (Epidermolysis Bullosa Herpetiformis Dowling Meara)
05/01/2010 - "Epidermolysis bullosa simplex due to KRT5 mutations: mutation-related differences in cellular fragility and the protective effects of trimethylamine N-oxide in cultured primary keratinocytes."
03/01/2009 - "Characterization of immortalized human epidermolysis bullosa simplex (KRT5) cell lines: trimethylamine N-oxide protects the keratin cytoskeleton against disruptive stress condition."
01/30/2015 - "Chronic dietary exposures that increase TMAO directly contributes to progressive renal fibrosis and dysfunction in animal models."
01/01/2016 - "In addition, myocardial fibrosis was also significantly greater (P<0.01, each) in the TMAO and choline groups relative to controls. "
01/30/2015 - "In animal models, elevated dietary choline or TMAO directly led to progressive renal tubulointerstitial fibrosis and dysfunction. "
01/01/2016 - "Twelve weeks post transverse aortic constriction, myocardial tissues were collected to evaluate cardiac and vascular fibrosis, and blood samples were evaluated for cardiac brain natriuretic peptide, choline, and TMAO levels. "
|1.||trimethyloxamine (trimethylamine N-oxide)
|2.||Choline (Choline Chloride)
|4.||Adenosine Triphosphate (ATP)
|8.||dimethylaniline monooxygenase (N-oxide forming) (flavin-containing monooxygenase)
|1.||Transplantation (Transplant Recipients)
|3.||Renal Dialysis (Hemodialysis)