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tisopurine
4-thio analog of allopurinol; structure
Also Known As:
4-mercaptopyrazolo(3,4-d)pyrimidine; thiopurinol
Networked:
7
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
Fused-Ring Heterocyclic Compounds
2-Ring Heterocyclic Compounds
Purines: 651
Allopurinol: 3719
tisopurine: 7
Related Diseases
1.
Hepatitis
01/01/1997 - "
[Acute hepatitis caused by tisopurine.
"
01/01/1996 - "
An association of varying degrees was noted between aplastic anaemia and the following conditions or treatments: clinical hepatitis during the past 6 months; history of chronic immune disorder (mainly rheumatoid arthritis); gold salts and D-penicillamine; colchicine and allo-thiopurinol; acetaminophen and salicylates.
"
2.
Gout
04/01/1974 - "
3 Reduced inosine formation, following one week of thiopurinol therapy, has also been observed in vitro using the intact red cells from three patients suffering from gout.
"
09/01/1971 - "
[Preliminary clinical experiences with mercapto-pyrazolo-pyrimidine (thiopurinol) in the therapy of gout].
"
3.
Carcinogenesis
09/15/1991 - "
Inhibition by 2,6-dithiopurine and thiopurinol of binding of a benzo(a)pyrene diol epoxide to DNA in mouse epidermis and of the initiation phase of two-stage tumorigenesis.
"
4.
Paralysis (Palsy)
06/15/1989 - "
Out of these compounds, Thiopurinol (C5H4N4S) showed dose-dependent protection in mice from death/paralysis induced by collagen + adrenaline.
"
5.
Immune System Diseases (Immune Disorders)
01/01/1996 - "
An association of varying degrees was noted between aplastic anaemia and the following conditions or treatments: clinical hepatitis during the past 6 months; history of chronic immune disorder (mainly rheumatoid arthritis); gold salts and D-penicillamine; colchicine and allo-thiopurinol; acetaminophen and salicylates.
"
Related Drugs and Biologics
1.
Salts
2.
Salicylates
3.
Penicillamine (Cuprimine)
4.
Inosine
5.
Gold
6.
Epoxy Compounds (Epoxides)
7.
Epinephrine (Adrenaline)
8.
DNA (Deoxyribonucleic Acid)
9.
Collagen
10.
Colchicine
Related Therapies and Procedures
1.
Therapeutics