|1.||Merrill, Alfred H: 5 articles (04/2011 - 01/2007)|
|2.||Ahn, Eun Hyun: 4 articles (07/2010 - 05/2002)|
|3.||Schroeder, Joseph J: 4 articles (07/2010 - 05/2002)|
|4.||Bielawski, Jacek: 3 articles (01/2015 - 09/2010)|
|5.||Ling, Leong-Uung: 3 articles (08/2014 - 12/2009)|
|6.||Chiu, Gigi N C: 3 articles (08/2014 - 12/2009)|
|7.||Tan, Kuan-Boone: 3 articles (08/2014 - 12/2009)|
|8.||Chng, Wee-Joo: 2 articles (08/2014 - 06/2012)|
|9.||Bunte, Ralph M: 2 articles (08/2014 - 06/2012)|
|10.||Yura, Yoshiaki: 2 articles (01/2014 - 03/2009)|
01/01/2011 - "Taken together, our data suggested that ROS was the mediator of safingol-induced cancer cell death, and autophagy is likely to be a mechanism triggered to repair damages from ROS generation on safingol treatment."
05/15/2003 - "We illustrate these methods with a case-control study that was designed to assess the risk of oesophageal cancer as a function of the quartile categories of sphinganine levels in the blood serum. "
09/20/1995 - "Preclinical animal studies show that safingol alone has a minimal effect on tumor cell growth, but combining this compound with conventional chemotherapy agents dramatically potentiates their antitumor effects. "
02/01/2012 - "These findings provide a molecular basis of γTE-stimulated cancer cell death and support the notion that elevation of intracellular dihydroceramide and dihydrosphingosine is likely a novel anticancer mechanism."
04/15/2011 - "A phase I clinical trial of safingol in combination with cisplatin in advanced solid tumors."
09/01/2011 - "The resistance of the null mpk6 mutant to manifest PCD on FB1 and sphinganine addition and the failure to show resistance on pathogen infection and MPK6 activation by FB1 and LCBs indicated that MPK6 mediates PCD downstream of LCBs. "
11/01/2012 - "We showed that dihydrosphingosine exclusively endowed nanomolar antiviral activity to the peptides (IC(50) as low as 120 nM) in HIV-1 infection on TZM-bl cells and on Jurkat T cells, as well as in the cell-cell fusion assay. "
09/24/2010 - "Pseudomonas syringae infection triggers de novo synthesis of phytosphingosine from sphinganine in Arabidopsis thaliana."
09/01/1995 - "The candida infections, treated daily with 1.5% sphinganine in ethanol, showed no improvement in inflammation compared with controls, except for 2 days of the 2-week observation period (P = 0.01-0.03); however, by the fourth day of therapy the yeast was eliminated in 75% of animals. "
03/01/2015 - "Particularly, sphingosine, sphinganine, and C24Cer appear as promising novel biomarkers in chronic HCV infection and should be further evaluated within the noninvasive prediction of liver fibrosis."
|3.||Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
06/10/2012 - "In vivo efficacy of a novel liposomal formulation of safingol in the treatment of acute myeloid leukemia."
08/01/2014 - "The aim of this work was to develop a liposomal formulation to facilitate delivery of a synergistic safingol/C2-ceramide combination in the treatment of acute myeloid leukemia (AML). "
08/01/2004 - "However, hypoxia affected 4-HPR + safingol cytotoxicity to a lesser extent (P = 0.04; 4-HPR LC(99), 4.9 +/- 2.3 microm; range, 2.0-8.2). "
05/03/2010 - "Tumor hypoxia-induced marked accumulation of sphinganine (dihydrosphingosine) long-chain base, and significant reduction of unsaturated very long-chain fatty acids in the ceramide moiety. "
08/01/2004 - "We determined the following: (a) 4-HPR cytotoxicity against 12 ESFT cell lines in vitro; (b) whether 4-HPR increased ceramide species (saturated and desaturated ceramides); (c) whether physiological hypoxia (2% O(2)) affected cytotoxicity, mitochondrial membrane potential (DeltaPsi(m)) change, or ceramide species or reactive oxygen species levels; (d) whether cytotoxicity was enhanced by l-threo-dihydrosphingosine (safingol); (e) whether physiological hypoxia increased acid ceramidase (AC) expression; and (f) the effect of the AC inhibitor N-oleoyl-ethanolamine (NOE) on cytotoxicity and ceramide species. "
|2.||Fatty Acids (Saturated Fatty Acids)
|3.||Ethanol (Ethyl Alcohol)
|1.||Drug Therapy (Chemotherapy)