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pivalic acid

RN given refers to parent cpd; structure

Also Known As:

2,2-dimethylpropionic acid; pivalic acid, sodium salt

Networked: 16 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Carboxylic Acids: 973
  - Acyclic Acids
    - Valerates: 135
      - Pentanoic Acids: 1
        pivalic acid: 16
Lipids: 114793
- Fatty Acids: 27405
  - Volatile Fatty Acids: 3052
    - Valerates: 135
      - Pentanoic Acids: 1
        pivalic acid: 16

Experts

1.	Aboagye, Eric O: 1 article (07/2021)
2.	Abrahams, Joel: 1 article (07/2021)
3.	Allott, Louis: 1 article (07/2021)
4.	Ashek, Ali: 1 article (07/2021)
5.	Barnes, Chris: 1 article (07/2021)
6.	Braga, Marta: 1 article (07/2021)
7.	Brickute, Diana: 1 article (07/2021)
8.	Carcaboso, Angel M: 1 article (07/2021)
9.	Hajitou, Amin: 1 article (07/2021)
10.	Przystal, Justyna: 1 article (07/2021)

Related Diseases

1.	Hypoglycemia (Reactive Hypoglycemia) 10/01/2014 - "Infants often develop hypocarnitinemia and resultant hypoglycemia during long-term treatment with antibiotics that contain pivalic acid, but it is unknown whether maternal treatment with such agents during pregnancy induces hypocarnitinemia in fetuses or neonates. " 01/01/2018 - "As a consequence, long-term administration of pivalic acid containing antibiotics has been associated with depletion of free carnitine, inhibition of energy production and subsequent hypoglycemia. " 01/01/2017 - "Long-term treatment with antibiotics containing pivalic acid may decrease serum carnitine concentration and can sometimes be associated with severe hypoglycemia and encephalopathy in infants. "
2.	Brain Diseases (Brain Disorder) 01/01/2013 - "Exposure to antibiotics containing pivalic acid was associated with encephalopathy and progression to lethal cardiac arrhythmia in patients suffering from PCD." 01/01/2013 - "Primary carnitine deficiency and pivalic acid exposure causing encephalopathy and fatal cardiac events." 09/01/2007 - "Carnitine-associated encephalopathy caused by long-term treatment with an antibiotic containing pivalic acid." 01/01/2017 - "Long-term treatment with antibiotics containing pivalic acid may decrease serum carnitine concentration and can sometimes be associated with severe hypoglycemia and encephalopathy in infants. "
3.	isovaleric Acidemia 01/01/2014 - "We report a case of false-positive metabolic screening for isovaleric acidemia in a newborn due to treatment of the mother with pivalic acid containing antibiotics before delivery. " 08/06/1999 - "The increasing false positive rate due to the use of pivalic acid-containing antibiotics in the diagnosis of isovaleric acidemia was a problem in Japan." 02/25/2019 - "isovalerylcarnitine, 2methylbutyrilcarnitine, or pivaloylcarnitine) elevation, SBCAD deficiency is detectable at newborn screening, requiring differential diagnosis from isovaleric acidemia and pivalic acid administration. "
4.	Infant Death 09/01/2016 - "A case of sudden unexpected infant death involving a homozygotic twin with the thermolabile CPT2 variant, accompanied by rotavirus infection and treatment with an antibiotic containing pivalic acid."
5.	Walker-Warburg Syndrome 01/01/2017 - "We describe a 6-year-old Japanese girl with Fukuyama-type congenital muscular dystrophy who lost consciousness after 3 days of treatment with an antibiotic containing pivalic acid (cefditoren pivoxil). "

Related Drugs and Biologics

1.	Anti-Bacterial Agents (Antibiotics)
2.	Carnitine (L-Carnitine)
3.	Prodrugs
4.	Cardiotoxins
5.	Butyric Acid (Butanoic Acid)
6.	Anthracyclines
7.	Cyclosporine (Ciclosporin)
8.	Zidovudine (Retrovir)
9.	Nitroprusside (Sodium Nitroprusside)
10.	Mycotoxins