propamidine

structure given in first source

Also Known As:

1,3-bis(p-amidinophenoxy)propane; 1,3-di-(4-amidinophenoxy)propane; 1,3-di-(p-amidinophenoxymethyl)-propane; 4,4'-(trimethylenedioxy)dibenzamidine; DAPP-Br; DAPP-H; propamidine dihydrochloride

Networked: 33 relevant articles (6 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amidines: 14
  - Benzamidines: 5
    - propamidine: 33

Experts

1.	Arnalich-Montiel, F: 1 article (11/2020)
2.	Carrillo-Gijon, R: 1 article (11/2020)
3.	Lopez-Velez, R: 1 article (11/2020)
4.	Lorenzo-Morales, J: 1 article (11/2020)
5.	de Dompablo, E: 1 article (11/2020)
6.	de-Arriba-Palomero, P: 1 article (11/2020)
7.	Coles, Steven: 1 article (09/2019)
8.	Hamad, Anas: 1 article (09/2019)
9.	Hau, Scott: 1 article (09/2019)
10.	Heaselgrave, Wayne: 1 article (09/2019)

Related Diseases

1.	Acanthamoeba Keratitis 01/01/1998 - "The use of PHMB and propamidine cured all cases of Acanthamoeba keratitis. " 01/01/1996 - "The combination of topical chlorhexidine and propamidine was very effective for treating Acanthamoeba keratitis provided the drugs were continued for a sufficient period. " 10/05/2023 - "The Orphan Drug for Acanthamoeba Keratitis (ODAK) Trial: PHMB 0.08% (Polihexanide) and Placebo versus PHMB 0.02% and Propamidine 0.1." 10/05/2023 - "To compare topical PHMB (polihexanide) 0.02% (0.2 mg/ml)+ propamidine 0.1% (1 mg/ml) with PHMB 0.08% (0.8 mg/ml)+ placebo (PHMB 0.08%) for Acanthamoeba keratitis (AK) treatment. " 04/01/2002 - "To report patients with acanthamoeba keratitis treated with the association of propamidine (Brolene) and polyhexamethylbiguanide (PHMB) 0.02%. "
2.	Infections 01/01/1979 - "Propamidine, one of the diamidines used against infections with babesiae has inhibitory and enhancing effects on complement activation as assessed by immune haemolysis of sensitized sheep red cells. " 04/01/2015 - "After initial improvement in one patient, the infection worsened, necessitating the addition of Polyhexamethylene Biguanide (PHMB) and propamidine. " 04/01/2004 - "The corneal infection resolved with 5 months of topical polyhexamethylene biguanide and propamidine treatment. " 01/01/1996 - "In vitro sensitivity to chlorhexidine and propamidine was performed on all isolates and compared with sensitivity to a range of other drugs used for treatment of the infection. " 01/01/1999 - "Because of improved clinical detection and earlier diagnosis, the infection can often be controlled with a combination therapy of polyhexamethylene biguanide or chlorhexidine with propamidine and neomycine. "
3.	Cysts 02/01/1992 - "The reasons for the treatment failure in one case, despite cyst sensitivity to both PHMB and propamidine, are not clear. " 02/01/1995 - "As a result of these data, a kinetic study carried out on propamidine, hexamidine, and octamidine demonstrated that the amoebicidal effects resulted from two events: the diffusion of molecules through the plasma membrane or the double wall of trophozoites or cysts, respectively, and the lethal effects of molecules on amoebic protoplasm. " 08/01/2003 - "However, only half the patients responded to this regimen as the cysts were often resistant to neomycin and relatively insensitive to propamidine. " 01/01/1996 - "In vitro drug testing confirmed that trophozoites and cysts of all 12 Acanthamoeba isolates were fully sensitive to chlorhexidine and propamidine. " 11/01/1998 - "Vahlkampfia cysts were identified in case 1, and Naegleria cysts in case 2. Topical treatment with polyhexamethylene biguanide and propamidine resolved the keratitis in case 1. Case 2 was lost to follow-up. "
4.	Keratitis 10/01/1987 - "Acanthamoebic keratitis diagnosed by paracentesis and biopsy and treated with propamidine." 10/31/1992 - "[Treatment with a derivative of propamidine for keratitis in a user of soft lenses]." 07/01/2017 - "Although the treatment was limited to low-dose propamidine monotherapy because of reduced tolerability, the keratitis healed with almost no scarring after 13 months of consequent medication." 11/01/1998 - "Vahlkampfia cysts were identified in case 1, and Naegleria cysts in case 2. Topical treatment with polyhexamethylene biguanide and propamidine resolved the keratitis in case 1. Case 2 was lost to follow-up. " 02/01/1995 - "Because some Acanthamoeba strains have been reported to be resistant to propamidine and propamidine was found to be only weakly cysticidal, superior homologs such as butamidine, pentamidine, hexamidine, heptamidine, octamidine, and nonamidine were tested for their amoebicidal effects on two Acanthamoeba strains isolated from patients with keratitis. "
5.	Ulcer 11/01/2009 - "We started specific therapy with propamidine 0.1% and polyhexamethylene biguanide 0.02% eyedrops; we suspended propamidine therapy after 2 weeks form the onset, when the ulcer had recovered, and we continued topical therapy with polyhexamethylene biguanide 0.02% for 6 months. " 02/01/2010 - "Initial corneal scrapings and culture confirmed Acanthamoeba and Fusarium solani, corroborated by in vivo confocal microscopy findings, yet despite topical chlorhexidine 0.02%, propamidine 1%,neomycin/polymyxin B ointment, and natamycin 5% along with oral itraconazole, the ulcer worsened. "

Related Drugs and Biologics

1.	Chlorhexidine
2.	polihexanide
3.	Neomycin
4.	dibrompropamidine
5.	Ointments (Pastes)
6.	Anti-Bacterial Agents (Antibiotics)
7.	hexamidine
8.	Ophthalmic Solutions (Eye Drops)
9.	Biguanides
10.	Povidone-Iodine (Betadine)

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)
3.	Penetrating Keratoplasty
4.	Lenses
5.	Debridement