prephenic acid (prephenate)

nonaromatic biosynthetic intermediate, probable immediate precursor of aromatic systems such as phenylalanine, tyrosine, tannins, flavanoids; isolated from cultures of mutant E coli; structure

Also Known As:

prephenate; 1-carboxy-4-hydroxy-2,5-cyclohexadiene-1-pyruvic acid

Networked: 5 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Alicyclic Hydrocarbons: 1
      - Cycloparaffins: 6
        Cyclohexanes: 3
        Cyclohexenes: 4
        prephenic acid: 5
        Cyclohexanecarboxylic Acids
        prephenic acid: 5
- Carboxylic Acids: 973
  - Carbocyclic Acids
    - Cyclohexanecarboxylic Acids
      - prephenic acid: 5

Experts

1.	Martí, M A: 1 article (01/2016)
2.	Ramírez, C L: 1 article (01/2016)
3.	Roitberg, A E: 1 article (01/2016)
4.	Anterola, Aldwin M: 1 article (10/2007)
5.	Bedgar, Diana L: 1 article (10/2007)
6.	Bernards, Mark A: 1 article (10/2007)
7.	Cho, Man-Ho: 1 article (10/2007)
8.	Corea, Oliver R A: 1 article (10/2007)
9.	Davin, Laurence B: 1 article (10/2007)
10.	Hood, Rebecca L: 1 article (10/2007)

Related Diseases

1.	Conversion Disorder (Astasia Abasia) 01/01/2016 - "In this small review, using the extensively studied chorismate to prephenate conversion reaction, we first present a systematic study of how key parameters such as pulling speed, number of trajectories, and reaction progress are related to the resulting work distributions and in turn the accuracy of the free energy obtained with JR. " 05/18/2005 - "The conversion reaction of chorismate to prephenate catalyzed by the Bacillus subtilis enzyme chorismate mutase has been chosen as an illustrative example."
2.	Dehydration (Water Stress) 07/25/1978 - "A reaction sequence is proposed for the conversion of prephenate to DHPA, involving an allylic rearrangement, followed by 1,4 reduction of the resulting conjugated diene and a combined decarboxylation/dehydration." 10/19/2007 - "This is because both prephenate and arogenate have been reported to undergo decarboxylative dehydration in plants via the action of either arogenate (ADT) or prephenate (PDT) dehydratases; however, neither enzyme(s) nor encoding gene(s) have been isolated and/or functionally characterized. "
3.	Starvation 12/01/1971 - "TyrA mutants which had mutase T were considerably derepressed in this activity by tyrosine starvation and consequently excreted prephenate. "

Related Drugs and Biologics

1.	Enzymes
2.	Tyrosine (L-Tyrosine)
3.	Hydro-Lyases (Dehydratases)
4.	Chorismate Mutase
5.	9-(2,3-dihydroxypropyl)adenine
6.	pretyrosine
7.	1-phenyl-3,3-dimethyltriazene (PDT)