azulene

12/01/2014 - "P-AG dramatically reduced the incidence of moderate-to-severe oral mucositis as compared to the control group treated with azulene gargle (20% versus 82% for grade ≥ 2, p<0.01; 0% versus 45% for grade ≥ 3, p<0.01). "
08/01/2018 - "Grade≥ 3 oral mucositis occurred in 5 (83.3%) of 6 patients receiving azulene gargle, but in 2 (20%) patients who took PZ-AG (p=0.035). "
01/01/2005 - "Sodium azulene sulfonate is clinically used as a therapeutic agent in the treatment of pharyngitis as well as other inflammatory diseases such as tonsillitis, stomatitis and conjunctivitis. "
01/01/2018 - "The efficacy of sodium azulene sulfonate L-glutamine (GA) in treating oral mucositis caused by the administration of anticancer agents has not been previously elucidated. "
01/01/2018 - "The efficacy of sodium azulene sulfonate L-glutamine for managing chemotherapy-induced oral mucositis in cancer patients: a prospective comparative study."

06/01/2020 - "Anti-Cancer and Anti-Inflammatory Activities of Bromo- and Cyano-Substituted Azulene Derivatives."
02/01/1957 - "[Growth retardation by certain extracts of chamomile flowers and a synthetic azulene preparation in experimental mouse tumors]."
05/01/2018 - "QSAR analysis demonstrated that their tumor-specificity of azulene amide derivatives was correlated with hydrophobicity and molecular shape. "
05/01/2018 - "We investigated here the relative cytotoxicity of 10 azulene amide derivatives against cancer and normal cells. "
05/01/2018 - "In Vitro Anti-tumor Activity of Azulene Amide Derivatives."

08/22/1959 - "[Cytological studies in evaluation of the therapeutic efficacy of an azulene-containing preparation (azulone liquidum) in gastritis]."
01/24/1964 - "[TREATMENT OF GASTRITIS AND PEPTIC ULCER WITH SUCSAN-AZULENE COMPOSITUM]."

09/01/2007 - "As the throat discomfort caused by the throat inflammation improved with azulene gargling, her water intake was reduced, and the serum Na concentration returned to normal. "
10/10/1957 - "[Inflammation-inhibiting effect of azulene]."
01/01/2009 - "Azulene has been recognized for its application in medicinal therapy against inflammation. "
01/01/1975 - "[Clinical effects of water-soluble azulene upon inflammation and postoperative inflammation in oral surgery (author's transl)]."
05/23/1960 - "[On possible azulene therapy of chronic inflammations of the large intestine]."

01/01/2011 - "Viable cell number of human oral normal cells (gingival fibroblast, pulp cell and periodontal ligament fibroblast) and three oral squamous cell carcinoma cell lines on treatment with various concentrations of each azulene-related compound was evaluated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) method. "
07/01/2019 - "Very few studies of anticancer activity of azulene amides led us to investigate the cytotoxicity of 21 N-alkylazulene-1-carboxamides introduced either with 3-methyl [1-7], 7-isopropyl-3-methyl [8-14] or 2-methoxy group [15-21] Materials and Methods: Tumor-specificity (TS) was calculated by the ratio of mean 50% cytotoxic concentration (CC50) against three normal human oral mesenchymal cells to that against four human oral squamous cell carcinoma (OSCC) cell lines. "