|1.||Sethi, Gautam: 6 articles (06/2013 - 09/2007)|
|2.||Lee, Mi-Kyung: 5 articles (07/2014 - 01/2009)|
|3.||Slaga, Thomas J: 4 articles (11/2015 - 12/2013)|
|4.||Ebert, Scott M: 4 articles (10/2015 - 06/2011)|
|5.||Adams, Christopher M: 4 articles (10/2015 - 06/2011)|
|6.||Chen, Jianzhong: 4 articles (04/2015 - 01/2014)|
|7.||Jia, Lee: 4 articles (04/2015 - 01/2014)|
|8.||Shao, Jingwei: 4 articles (04/2015 - 01/2014)|
|9.||Kumar, Alan Prem: 4 articles (06/2013 - 07/2011)|
|10.||Shanmugam, Muthu K: 4 articles (06/2013 - 07/2011)|
08/01/2015 - "While ursolic acid (UA), one of the most broadly known triterpene compounds, has proved to be effective in cancer therapy, the applications of UA is limited due to its poor aqueous solubility and low bioavailability. "
04/05/2015 - "The anticancer efficacy of ursolic acid (UA) was limited by poor water solubility, non-specific tumor distribution, and low bioavailability. "
06/01/2013 - "Ursolic acid in cancer prevention and treatment: molecular targets, pharmacokinetics and clinical studies."
01/01/2013 - "The current study aims to evaluate the single- and multiple-dose pharmacokinetics (PK) as well as the safety of ursolic acid nanoliposomes (UANL) in healthy volunteers and in patients with advanced solid tumors. "
01/01/2013 - "A phase I pharmacokinetic study of ursolic acid nanoliposomes in healthy volunteers and patients with advanced solid tumors."
04/01/2015 - "CCl4-induced profound elevations of oxidative stress, inflammation and apoptosis in liver were suppressed by ursolic acid. "
05/01/2014 - "Ursolic acid protects mouse liver against CCl4-induced oxidative stress and inflammation by the MAPK/NF-κB pathway."
01/01/2008 - "Ursolic acid (UA), a natural pentacyclic triterpenoid carboxylic acid, is the major component of some traditional medicine herbs and is well known to possess a wide range of biological functions, such as antioxidative, anti-inflammation, and anticancer activities, that are able to counteract endogenous and exogenous biological stimuli. "
04/01/2015 - "The inhibition of CCl4-induced liver fibrosis, inflammation and apoptosis by ursolic acid is due at least in part to its ability to modulate the Nrf2/ARE signalling pathway."
02/15/2013 - "To investigate the anti-asthmatic effects and mechanism of ursolic acid, we studied the development of pulmonary eosinophilic inflammation and enhanced pause (Penh) in a mouse model of allergic asthma. "
09/01/2014 - "Ursolic acid ameliorates autoimmune arthritis via suppression of Th17 and B cell differentiation."
12/01/2015 - "Thus niosomal gel of ursolic acid would be a promising alternative to conventional therapy for safe and efficient treatment of arthritis and musculoskeletal disorders. "
03/01/2006 - "Amelioration of adjuvant-induced arthritis by ursolic acid through altered Th1/Th2 cytokine production."
12/01/2015 - "The aim of the present study was to optimize niosomes by experimental design for enhanced transdermal delivery of ursolic acid for the effective treatment of arthritis. "
03/01/2006 - "We applied Cytometric bead array (CBA) technology for simultaneously measurement of these cytokines in adjuvant inflammatory arthritis induced mice treated with ursolic acid in graded oral doses. "
|4.||Wounds and Injuries (Trauma)
01/01/2014 - "Administration of ursolic acid attenuated trauma-hemorrhagic shock-induced hepatic and lung injuries in rats. "
08/26/2013 - "The animals treated with the extracts and fractions (5%) showed significant reduction in wound area 96.55 and 96.41% with faster epithelialisation (17.50 and 17.86), while the isolated compounds bergenin and ursolic acid heal the wound faster, but complete epithelialisation with 100% wound contraction was evident with 5% povidone-iodine group on 18th post-wounding day. "
01/01/2014 - "Ursolic acid inhibits superoxide production in activated neutrophils and attenuates trauma-hemorrhage shock-induced organ injury in rats."
01/01/2014 - "In conclusion, ursolic acid, a bioactive natural compound, inhibits superoxide anion generation and elastase release in human neutrophils and ameliorates trauma-hemorrhagic shock-induced organ injury in rats. "
01/01/2014 - "In addition, administration of ursolic acid attenuated the hepatic malondialdehyde levels and reduced the plasma aspartate aminotransferase and alanine aminotransferase levels after trauma-hemorrhagic shock. "
08/01/2011 - "Ursolic acid ameliorates hepatic fibrosis in the rat by specific induction of apoptosis in hepatic stellate cells."
08/01/2015 - "This study used in vitro and in vivo models to examine the effects of ursolic acid (UA) on myocardial fibrosis and to explore its potential mechanism. "
07/01/2013 - "[Study on the effect of ursolic acid (UA) on the myocardial fibrosis of experimental diabetic mice]."
04/01/2015 - "Ursolic acid significantly prevented CCl4-induced hepatotoxicity and fibrosis, indicated by both diagnostic indicators and histopathological analysis. "
03/01/2015 - "This study is to investigate the effects of ursolic acid (UA) on liver functions and fibrosis in bile duct ligation (BDL) mice and to determine the underlying mechanisms. "
|2.||Carbon Tetrachloride (Tetrachloromethane)
|8.||Glycyrrhizic Acid (Glycyrrhizin)
|1.||Drug Therapy (Chemotherapy)
|2.||Heterologous Transplantation (Xenotransplantation)
|5.||Chinese Traditional Medicine (Traditional Chinese Medicine)