norvaline

differs from valine in being 1 carbon longer instead of branched; RN given refers to (L)-isomer; structure

Also Known As:

alpha-aminovaleric acid; norvaline, (DL)-isomer; 2-Aminopentanoic acid

Networked: 26 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Amino Acids: 30675
  - Branched-Chain Amino Acids: 2289
    - Valine: 1999
      - norvaline: 26
  - Essential Amino Acids: 1152
    - Valine: 1999
      - norvaline: 26

Experts

1.	Polis, Baruh: 6 articles (05/2022 - 10/2018)
2.	Samson, Abraham O: 6 articles (05/2022 - 10/2018)
3.	Gurevich, Vyacheslav: 3 articles (05/2022 - 09/2019)
4.	Srikanth, Kolluru D: 3 articles (05/2022 - 10/2018)
5.	Assa, Michael: 2 articles (05/2022 - 09/2019)
6.	Gilinsky, Michael A: 2 articles (01/2020 - 12/2019)
7.	Gil-Henn, Hava: 2 articles (09/2019 - 10/2018)
8.	Hu, Yu: 1 article (08/2022)
9.	Li, Xin: 1 article (08/2022)
10.	Luo, Na: 1 article (08/2022)

Related Diseases

1.	Neurodegenerative Diseases (Neurodegenerative Disease) 09/18/2019 - "L-norvaline self-evidently interferes with AD pathogenesis and presents a potent remedy for angiopathies and neurodegenerative disorders intervention." 09/01/2019 - "As such, L-norvaline is a promising neuroprotective molecule that might be tailored for the treatment of a range of neurodegenerative disorders. "
2.	Neoplasms (Cancer) 01/01/2023 - "In this study, we found that L-Norvaline inhibits tumor growth in vivo. " 01/01/2023 - "Significantly, L-Norvaline did not inhibit tumor growth in immunodeficient mice. " 01/01/2023 - "This study implied the possibility of L-Norvaline as a modulator of the immune response in cancer and provided a new potential therapy combined with ADI-PEG 20." 01/01/2023 - "In addition, combination treatment with L-Norvaline and ADI-PEG 20 induced a more robust anti-tumor response against B16F10 melanoma. " 01/01/2023 - "To target tumor cells and their neighboring immune cells, we hypothesized that the combination of an arginase inhibitor (L-Norvaline) and ADI-PEG 20 may trigger a stronger anticancer response. "
3.	Osteoporosis 01/01/2018 - "The experiment was carried out on 120 female white Wistar rats, to study the endothelio- and osteoprotective action of the combination of rosuvastatin with L-norvaline in the model of experimental osteoporosis. "
4.	Alzheimer Disease (Alzheimer's Disease) 09/18/2019 - "Norvaline Restores the BBB Integrity in a Mouse Model of Alzheimer's Disease." 09/01/2019 - "L-Norvaline, a new therapeutic agent against Alzheimer's disease." 10/01/2018 - "L-Norvaline Reverses Cognitive Decline and Synaptic Loss in a Murine Model of Alzheimer's Disease." 05/01/2022 - "Effects of Chronic Arginase Inhibition with Norvaline on Tau Pathology and Brain Glucose Metabolism in Alzheimer's Disease Mice."
5.	Cognitive Dysfunction 09/01/2019 - "Remarkably, L-norvaline treatment reverses the cognitive decline in AD mice. " 10/01/2018 - "L-Norvaline Reverses Cognitive Decline and Synaptic Loss in a Murine Model of Alzheimer's Disease."

Related Drugs and Biologics

1.	Rosuvastatin Calcium (Crestor)
2.	Arginase
3.	Esters
4.	Arginine (L-Arginine)
5.	Proline (L-Proline)
6.	Ornithine
7.	Methionine (L-Methionine)
8.	Amino Acids
9.	Therapeutic Uses
10.	Glucuronic Acid (Glucuronate)

Related Therapies and Procedures

1.	Therapeutics
2.	Aftercare (After-Treatment)