alpha-naphthyl thiourea (ANTU)

03/01/2022 - "Pulmonary edema was induced by administering ANTU intraperitoneally in the rats in the study group. "
03/01/2022 - "The aim of this study was to compare the humidity rates of expiratory air measured before and after pulmonary edema induced by α-naphthylthiourea (ANTU) in rats. "
11/01/1982 - "[Immuno-electron microscopical study on pulmonary edema induced by alpha-naphthylthiourea]."
11/01/1981 - "[Pulmonary edema induced by alpha-naphthylthiourea--usual ultrastructural, immuno-electron microscopical and freeze fracture studies]."
11/01/2023 - "Diffused inflammatory cell infiltration, interstitial pulmonary edema, and histopathological congestion were observed after the administration of ANTU. "

06/01/1984 - "However, platelet depletion studies suggest that 15-M-PGE1 has additional effects, possibly on endothelial cells and/or vascular smooth muscle cells that contribute to the potentiation of ANTU -induced lung injury."
06/01/1984 - "These studies indicate that systemic treatment of rats with 15-M-PGE1 will potentiate ANTU -induced lung injury. "
02/01/1995 - "ANTU alone and HCl alone caused a moderate histologic lung injury, increased wet/dry weight ratio, and resulted in a small increase in flux. "
04/01/1986 - "Transvascular clearance and distribution of charged macromolecules in ANTU lung injury."
06/01/1984 - "Platelet depletion, but not neutrophil depletion, also potentiated ANTU -induced lung injury, suggesting a protective role for platelets. "

11/01/2012 - "Dexmedetomidine treatment has demonstrated a potential benefit by preventing ANTU-induced acute lung injury in an experimental rat model. "
11/01/2012 - "We assessed the effects of dexmedetomidine in a rat model of α-naphthylthiourea (ANTU)-induced acute lung injury. "
09/01/2002 - "The effects of granulocyte colony-stimulating factor given alone or after alpha-naphthylthiourea used to induce acute lung injury were investigated. "
02/01/1995 - "The effect of G-CSF pretreatment on experimental acute lung injury was studied in Sprague-Dawley rats receiving one of the following treatments: (1) G-CSF 50 micrograms/kg subcutaneously twice daily beginning 2 d prior to being killed; (2) ANTU 50 mg/kg intraperitoneally; (3) ANTU+G-CSF 50, 25, or 12.5 micrograms/kg; (4) HCl 0.6 ml of a 0.1 N solution intratracheally; (5) HCl+G-CSF 50 or 25 micrograms/kg; (6) control solutions. "
01/01/1987 - "We conclude that lungs are capable of hydrolysis of triglyceride contained in chylomicrons and that this endothelial cell associated metabolic function is not altered by acute lung injury caused by ANTU."

08/15/2001 - "In keeping with this explanation, the lower Vuip and Crs were before HV, the more severe HV-induced edema was in alpha-naphthylthiourea-injected rats. "
08/15/2001 - "Changes in Vuip and in Crs produced by HV were correlated with edema severity in normal rats or rats with lungs preinjured with alpha-naphthylthiourea. "
02/01/1987 - "Sequential changes in lung metabolism, permeability, and edema after ANTU."
01/01/1987 - "We compared areas and diameters of small airways and arteries in three groups of anesthetized dogs: 1) control (n = 5), 2) hydrostatic edema induced by fluid overload (n = 13), and 3) increased permeability edema induced with alpha-naphthylthiourea (n = 5). "
01/01/1986 - "Whereas PEEP had no consistent effect on extravascular thermal volume in ANTU edema, there was a reversible increase in ETV during PEEP in animals with HCl or OA injury and underestimation of ELM. "

04/23/2021 - "Treatment with 2ME significantly reduced pleural effusion and, more importantly, eliminated acute mortality induced by ANTU (33% vs 0%, ANTU vs. ANTU+2ME group). "
06/01/1984 - "15-M-PGE1 (1 mg/kg) treatment combined with platelet depletion resulted in a 1.7-fold increase (p less than 0.01) in pleural effusions in ANTU -treated (1 mg/kg) animals compared with platelet depletion alone. "
08/01/1983 - "After 6 h, pulmonary extravascular water increased by 50% in ANTU-treated rats and the volume of the pleural effusion reached 3.4 +/- 0.1 ml (mean +/- s.e. "
01/01/1978 - "ANTU specifically increases pulmonary vascular permeability in adult rats and causes acute pulmonary oedema and pleural effusion. "
03/01/2022 - "Humidity, temperature, lung weight, pleural effusion, and histopathological changes in the respiratory system due to pulmonary edema were examined in the ANTU group. "