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mipafox

structure
Also Known As:
N,N'-di-isopropylphosphorodiamidic fluoride; N,N'-diisopropylphosphorodiamidic fluoride
Networked: 20 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Tiffany-Castiglioni, Evelyn: 2 articles (08/2006 - 07/2004)
2. Fernandes, Laís S: 1 article (08/2015)
3. dos Santos, Neife Aparecida Guinaim: 1 article (08/2015)
4. Barbosa, Fernando: 1 article (08/2015)
5. dos Santos, Antonio Cardozo: 1 article (08/2015)
6. de Paula, Eloísa Silva: 1 article (08/2015)
7. Emerick, Guilherme L: 1 article (08/2015)
8. Cho, Taehyeon M: 1 article (08/2006)
9. Donnelly, Kirby C: 1 article (08/2006)
10. Wild, James R: 1 article (08/2006)

Related Diseases

1. Neuroblastoma
2. Polyneuropathies (Polyneuropathy)
10/24/1997 - "The esterase activity in particulate forms, resistant to paraoxon and sensitive to mipafox have been implicated in the initiation of organophosphorus-induced delayed polyneuropathy (OPIDP) and is called neuropathy target esterase (P-NTE). "
06/01/1993 - "NTE (neuropathy target esterase) is considered to be the target for organophosphorus-induced delayed polyneuropathy and is operationally measured by radiolabelling or by determining its esteratic activity as the paraoxon-resistant mipafox-sensitive phosphorylable site(s). "
02/01/2000 - "Neuropathy target esterase (NTE), thought to be the target for organophosphate polyneuropathy, is operationally defined as that neural phenyl valerate esterase resistant to paraoxon (40 microM) and sensitive to mipafox (50 microM; 20 min, pH 8.0, 37 degrees C). "
06/15/2004 - "Organophosphorus-induced polyneuropathy is a syndrome related to the inhibition and further modification by organophosphorus compounds of NTE (a protein that displays phenyl valerate esterase activity resistant to mipafox and sensitive to paraoxon). "
05/14/1999 - "Neural carboxylesterases can be discriminated by differential inhibition assays with organophosphorus compounds (OPs), paraoxon (O,O'-diethyl p-nitrophenyl phosphate) and mipafox (N,N'-diisopropyl phosphorodiamidofluoridate) being the ones used to discriminate esterases that should be either irrelevant or candidates as targets of the mechanism of induction of the organophosphorus-induced delayed polyneuropathy (OPIDP). "
3. Poisoning
4. Ataxia (Dyssynergia)
5. Starvation

Related Drugs and Biologics

1. Paraoxon (E600)
2. phenylsaligenin cyclic phosphate (PSCP)
3. neurotoxic esterase
4. Isoflurophate (DFP)
5. Trichlorfon (Metrifonate)
6. Dichlorvos
7. Calpain
8. Calcium
9. Acetylcholinesterase
10. malaoxon