itaconic acid

Also Known As:

itaconate; itaconic acid, calcium salt; itaconic acid, copper salt; itaconic acid, disodium salt; itaconic acid, sodium salt; methylenebutanedioic acid; methylenesuccinic acid; methylidenebutanedioate

Networked: 197 relevant articles (9 outcomes, 27 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Carboxylic Acids: 973
  - Acyclic Acids
    - Dicarboxylic Acids: 108
      - Succinates: 13
        itaconic acid: 197

Experts

1.	O'Neill, Luke A J: 6 articles (11/2021 - 01/2019)
2.	Riquelme, Sebastián A: 4 articles (04/2021 - 01/2020)
3.	Michelucci, Alessandro: 3 articles (01/2022 - 05/2013)
4.	Prince, Alice: 3 articles (01/2022 - 01/2020)
5.	Zhang, Peng: 3 articles (01/2022 - 01/2020)
6.	Cordes, Thekla: 3 articles (01/2021 - 05/2013)
7.	Runtsch, Marah C: 3 articles (01/2020 - 01/2018)
8.	Artyomov, Maxim N: 3 articles (01/2019 - 12/2016)
9.	O'Neill, Luke A: 3 articles (01/2019 - 01/2018)
10.	Ryan, Dylan G: 3 articles (01/2019 - 01/2018)

Related Diseases

1.	Inflammation (Inflammations) 07/01/2020 - "Itaconate inhibited AAA formation by suppressing vascular inflammation, and therapeutic approaches to increase itaconate are potentially beneficial for preventing AAA formation. " 10/01/2022 - "Furthermore, treatment of microglia with itaconate demonstrated similar inflammation suppressive effects as Irg-1 overexpression in vitro and improved motor function recovery in vivo. " 12/20/2022 - "The results of the present study highlight the potential role of itaconic acid for the improvement of GCs inflammation in dairy cows with ovarian dysfunctions." 08/14/2018 - "The aim of this study was to determine the release rate of itaconic acid from pro-inflammatory activated macrophages in vitro and to test for the abundance of itaconic acid in bodyfluids of patients suffering from acute inflammation. " 10/23/2023 - "Therapeutically, exogenous itaconate was found to reduce injury-site inflammation, promoting tenogenic differentiation and impairing aberrant vascularization with disease-ameliorating effects. "
2.	Sepsis (Septicemia) 02/02/2022 - "This study aims to explore the regulatory role of itaconate on ferroptosis in sepsis-induced ALI. " 01/01/2023 - "Furthermore, itaconate and 4-OI inhibit the production of inflammatory factors in sepsis models. " 09/20/2019 - "Itaconic acid is found in low concentrations (0.5-2.3 µM) only at early-stage sepsis. " 01/01/2023 - "Our results broaden the knowledge on the role of the IRG1-itaconate axis in immunomodulation and highlight itaconate and its derivatives as potential therapeutic agents in sepsis." 07/20/2023 - "In conclusion, our data demonstrated that IRG1/itaconate protect against multi-organ injury via inhibiting inflammation response and GSDMD-indicated pyroptosis, which may be a promising agent for protecting against sepsis."
3.	Reperfusion Injury 01/01/2021 - "Integrative Analysis of the Roles of lncRNAs and mRNAs in Itaconate-Mediated Protection Against Liver Ischemia-Reperfusion Injury in Mice." 01/01/2020 - "The objective of this study was to investigate the molecular, metabolic, and physiological impact of itaconate treatment to mitigate reperfusion injuries in in vitro and in vivo model systems. " 10/01/2020 - "Immune-Responsive Gene 1/Itaconate Activates Nuclear Factor Erythroid 2-Related Factor 2 in Hepatocytes to Protect Against Liver Ischemia-Reperfusion Injury." 12/01/2016 - "Through this action, itaconate exerts anti-inflammatory effects when administered in vitro and in vivo during macrophage activation and ischemia-reperfusion injury. " 01/01/2022 - "In this study, we explore the role of Acod1 and itaconate in cerebral ischemia/reperfusion injury. "
4.	Infections 10/28/2023 - "Overall, our study expands the current understanding of the IRG1-itaconate axis in hvKP infection, providing a promising foundation for the development of innovative therapeutic strategies utilizing itaconate for the treatment of hvKP infections." 11/01/2023 - "Altogether, our results revealed that under physiological infection conditions, such as in the acidic phagolysome, itaconic acid is a highly effective antimicrobial against multi-resistant S. " 11/01/2023 - "Activated macrophages produce the immunometabolite itaconate as potent electrophile and antimicrobial upon pathogen infection. " 05/03/2023 - "Gene Expression Profiling of Classically Activated Macrophages in Leishmania infantum Infection: Response to Metabolic Pre-Stimulus with Itaconic Acid." 01/01/2023 - "This review examines the current state of itaconate research in infection and identifies the key challenges and opportunities for future research in this field."
5.	Psoriasis (Pustulosis Palmaris et Plantaris) 01/01/2019 - "Strikingly, two recent studies published in Nature showed that itaconate markedly decreases the production of proinflammatory mediators in lipopolysaccharide-treated macrophages and ameliorates sepsis and psoriasis in animal models, revealing a novel biological action of itaconate beyond its regular roles in antimicrobial defense. " 01/01/2021 - "In addition, dimethyl itaconate, an itaconate derivative, was reported to ameliorate disease severity in the animal models of psoriasis and multiple sclerosis. " 04/29/2020 - "Moreover, dimethyl itaconate (DMI), an itaconate derivative, inhibits IL-17-induced IκBς activation in keratinocytes and modulates IL-17-IκBς pathway-mediated skin inflammation in an animal model of psoriasis. " 01/01/2022 - "Itaconate and its derivatives have antiinflammatory effects in preclinical models of sepsis, viral infections, psoriasis, gout, ischemia/reperfusion injury, and pulmonary fibrosis, pointing to possible itaconate-based therapeutics for a range of inflammatory diseases. "

Related Drugs and Biologics

1.	dimethyl itaconate
2.	Lipopolysaccharides
3.	Arginine (L-Arginine)
4.	Heme Oxygenase-1
5.	gamma-Aminobutyric Acid (GABA)
6.	Gasdermins
7.	4-octyl itaconate
8.	Antioxidants
9.	Cytokines
10.	Interferons

Related Therapies and Procedures

1.	Analgesia
2.	Therapeutics
3.	Immunomodulation
4.	Resuscitation
5.	Microspheres (Microsphere)