|1.||Liu, Lili: 5 articles (01/2015 - 10/2003)|
|2.||Gerson, Stanton L: 4 articles (01/2015 - 10/2003)|
|3.||Kinsella, Timothy J: 4 articles (04/2013 - 02/2003)|
|4.||Donze, Jon R: 2 articles (03/2007 - 10/2003)|
|5.||Yan, Ling: 2 articles (03/2007 - 10/2003)|
|6.||Schupp, Jane E: 2 articles (04/2006 - 02/2003)|
|7.||Yang, Shuming: 2 articles (09/2005 - 10/2003)|
|8.||Xu, Yan: 2 articles (09/2005 - 10/2003)|
|9.||Pezuk, Julia A: 1 article (01/2015)|
|10.||Gerber, David E: 1 article (01/2015)|
01/01/2015 - "Combining ß-lapachone with XRCC1 knockdown or methoxyamine (MeOX), an apyrimidinic/apurinic (AP)-modifying agent, led to NQO1-dependent synergistic killing in PDA, NSCLC, breast and head and neck cancers. "
09/15/2005 - "Methoxyamine (MX) is a potential new anti-cancer drug. "
10/05/2003 - "Measurement of anti-cancer agent methoxyamine in plasma by tandem mass spectrometry with on-line sample extraction."
01/01/2015 - "This article explores the antiproliferative, proapoptotic and radiosensitizing effects of Methoxyamine (MX), a base excision repair (BER) inhibitor that has shown anticancer potential by sensitizing tumor cells to ionizing radiation and chemotherapy. "
04/01/2013 - "Methoxyamine (MX) is a small molecule chemical inhibitor of BER that is shown to enhance chemotherapy and/or IR cytotoxicity in human cancers. "
|2.||Myeloid Leukemia (Leukemia, Myelocytic)
08/01/2008 - "This study was to investigate apoptosis induced by manumycin combined with methoxyamine in myeloid leukemia cell line U937, and to explore the role of mitochondrial apoptotic pathway in apoptosis induction of the two drugs. "
08/01/2008 - "Methoxyamine enhances manumycin-induced apoptosis in U937 myeloid leukemia cells."
08/01/2008 - "[Effects of manumycin combined with methoxyamine on apoptosis in myeloid leukemia U937 cells]."
04/01/2005 - "We conclude that methoxyamine enhances manumycin-induced apoptosis in myeloid leukemia cells."
04/01/2005 - "Enhancement of manumycin A-induced apoptosis by methoxyamine in myeloid leukemia cells."
07/01/2013 - "We treated C6 and SHG44 glioma cells with β-elemene and methoxyamine individually or in combinations, and subsequently analyzed cellular survivals by MTT assay. "
07/01/2013 - "The cytotoxic effect of β-elemene against malignant glioma is enhanced by base-excision repair inhibitor methoxyamine."
05/01/2011 - "We also show that methoxyamine-induced potentiation of TMZ in MPG expressing glioma cells is abrogated by elevated-expression of the rate-limiting BER enzyme DNA polymerase β (Polβ), suggesting that cells proficient for BER readily repair AP sites in the presence of MX. "
07/01/2013 - "This study investigated the effects of β-elemene + methoxyamine, a DNA base-excision repair inhibitor, on the inhibition of glioma growth. "
05/01/2011 - "Using the human glioma cell lines LN428 and T98G, we report here that potentiation of TMZ via BER inhibition [methoxyamine (MX), the PARP inhibitors PJ34 and ABT-888 or depletion (knockdown) of PARG] is greatly enhanced by over-expression of the BER initiating enzyme MPG. "
|4.||Glioblastoma (Glioblastoma Multiforme)
11/01/2013 - "The results obtained in the present study demonstrated the efficiency of methoxyamine to overcome glioblastoma resistance to temozolomide treatment. "
11/01/2013 - "The aim of this study was to evaluate the cellular responses to temozolomide treatment associated with methoxyamine (blocker of base excision repair) in glioblastoma cell lines, in order to test the hypothesis that the blockage of base excision repair pathway might sensitize glioblastoma cells to temozolomide. "
11/01/2013 - "Methoxyamine sensitizes the resistant glioblastoma T98G cell line to the alkylating agent temozolomide."
|5.||Colonic Neoplasms (Colon Cancer)
02/15/2003 - "We also assessed the role of methoxyamine, a small molecule inhibitor of BER, in the response of human colon cancer cells (HCT116) to IdUrd cytotoxicity and radiosensitization. "
02/15/2003 - "Methoxyamine not only was able to increase IdUrd cytotoxicity but also increased the incorporation of IdUrd into DNA of HCT116 human colon cancer cells leading to greater radiosensitization. "
05/10/2001 - "Methoxyamine potentiates DNA single strand breaks and double strand breaks induced by temozolomide in colon cancer cells."
|4.||A-Form DNA (A-DNA)
|6.||DNA (Deoxyribonucleic Acid)
|8.||Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)
|1.||Drug Therapy (Chemotherapy)
|2.||Heterologous Transplantation (Xenotransplantation)