methoxyamine

09/15/2005 - "Methoxyamine (MX) is a potential new anti-cancer drug. "
10/05/2003 - "Measurement of anti-cancer agent methoxyamine in plasma by tandem mass spectrometry with on-line sample extraction."
04/01/2013 - "Methoxyamine (MX) is a small molecule chemical inhibitor of BER that is shown to enhance chemotherapy and/or IR cytotoxicity in human cancers. "
04/01/2013 - "Developing an in silico model of the modulation of base excision repair using methoxyamine for more targeted cancer therapeutics."
11/01/2016 - "Both tumor-growth rate and tumor-growth delay were significantly improved by adding methoxyamine to pemetrexed pre-irradiation (p<0.0001); no mice lost weight during treatment. "

11/01/2013 - "The results obtained in the present study demonstrated the efficiency of methoxyamine to overcome glioblastoma resistance to temozolomide treatment. "
11/01/2013 - "The aim of this study was to evaluate the cellular responses to temozolomide treatment associated with methoxyamine (blocker of base excision repair) in glioblastoma cell lines, in order to test the hypothesis that the blockage of base excision repair pathway might sensitize glioblastoma cells to temozolomide. "
01/01/2016 - "The purpose of this study was to evaluate the combination effect of resveratrol and methoxyamine on radiosensitivity of iododeoxyuridine in spheroid culture of U87MG glioblastoma cell line using colony formation and alkaline comet assays. "
01/01/2016 - "Effects of resveratrol and methoxyamine on the radiosensitivity of iododeoxyuridine in U87MG glioblastoma cell line."
11/01/2013 - "Methoxyamine sensitizes the resistant glioblastoma T98G cell line to the alkylating agent temozolomide."

07/01/2017 - "Methoxyamine Enhances 5-Fluorouracil-Induced Radiosensitization in Colon Cancer Cell Line HT29."
02/15/2003 - "We also assessed the role of methoxyamine, a small molecule inhibitor of BER, in the response of human colon cancer cells (HCT116) to IdUrd cytotoxicity and radiosensitization. "
07/01/2017 - "This study intended to observe the effects of methoxyamine (Mx) on cytotoxic effects and DNA damage caused by 5-Fluorouracil (5-FU) in combination with gamma radiation in a human colon cancer cell line, HT29. "
02/15/2003 - "Methoxyamine not only was able to increase IdUrd cytotoxicity but also increased the incorporation of IdUrd into DNA of HCT116 human colon cancer cells leading to greater radiosensitization. "
05/10/2001 - "Methoxyamine potentiates DNA single strand breaks and double strand breaks induced by temozolomide in colon cancer cells."

08/01/2008 - "This study was to investigate apoptosis induced by manumycin combined with methoxyamine in myeloid leukemia cell line U937, and to explore the role of mitochondrial apoptotic pathway in apoptosis induction of the two drugs. "
08/01/2008 - "Methoxyamine enhances manumycin-induced apoptosis in U937 myeloid leukemia cells."
08/01/2008 - "[Effects of manumycin combined with methoxyamine on apoptosis in myeloid leukemia U937 cells]."
04/01/2005 - "We conclude that methoxyamine enhances manumycin-induced apoptosis in myeloid leukemia cells."
04/01/2005 - "Enhancement of manumycin A-induced apoptosis by methoxyamine in myeloid leukemia cells."

07/01/2013 - "We treated C6 and SHG44 glioma cells with β-elemene and methoxyamine individually or in combinations, and subsequently analyzed cellular survivals by MTT assay. "
07/01/2013 - "The cytotoxic effect of β-elemene against malignant glioma is enhanced by base-excision repair inhibitor methoxyamine."
07/01/2013 - "This study investigated the effects of β-elemene + methoxyamine, a DNA base-excision repair inhibitor, on the inhibition of glioma growth. "
05/01/2011 - "We also show that methoxyamine-induced potentiation of TMZ in MPG expressing glioma cells is abrogated by elevated-expression of the rate-limiting BER enzyme DNA polymerase β (Polβ), suggesting that cells proficient for BER readily repair AP sites in the presence of MX. "
05/01/2011 - "Using the human glioma cell lines LN428 and T98G, we report here that potentiation of TMZ via BER inhibition [methoxyamine (MX), the PARP inhibitors PJ34 and ABT-888 or depletion (knockdown) of PARG] is greatly enhanced by over-expression of the BER initiating enzyme MPG. "