methixene (metixene)

RN given refers to parent cpd; structure

Also Known As:

metixene; methixene hydrochloride; 1-methyl-3-(thioxanthen-9-ylmethyl)- piperidine hydrochloride; Tremarit; methixene hydrochloride, monohydrate

Networked: 9 relevant articles (0 outcomes, 0 trials/studies)

Drug Context: Research Results

Organic Chemicals: 133
- Sulfur Compounds: 278
  - Thioxanthenes: 11
    - methixene: 9
Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 3-Ring Heterocyclic Compounds
    - Xanthenes: 65
      - Thioxanthenes: 11
        methixene: 9

Experts

1.	Gavard, Julie: 1 article (01/2016)
2.	Tjioe, Kellen Cristine: 1 article (01/2016)
3.	Tostes Oliveira, Denise: 1 article (01/2016)

Related Diseases

1.	Tremor (Tremors) 06/17/1983 - "[The treatment of Parkinson tremors and forms of extrapyramidal tremors with methixene. " 11/25/1977 - "[Follow-up studies in the treatment of extrapyramidal tremor forms with metixene]." 02/01/1966 - "Therapeutic action of methixene hydrochloride on Parkinsonian tremor and a description of a new tremor-recording transducer."
2.	Parkinsonian Disorders (Parkinsonism) 10/01/1966 - "[Treatment of drug-induced parkinsonism-like states with a drug used in the therapy of parkinsonism (methixene HCl)]."
3.	Parkinson Disease (Parkinson's Disease) 07/01/1967 - "A clinical evaluation of chlorphenoxamine with caffeine in the treatment of Parkinson's disease, including a comparison with methixene."
4.	Neoplasms (Cancer) 10/17/2023 - "Metixene is an incomplete autophagy inducer in preclinical models of metastatic cancer and brain metastases." 10/17/2023 - "Functional analysis revealed that metixene induced incomplete autophagy through N-Myc Downstream Regulated 1 (NDRG1) phosphorylation thereby leading to caspase-mediated apoptosis in both primary and brain metastatic cells, regardless of cancer subtype or origin. "
5.	Mouth Neoplasms (Oral Cancer) 01/01/2016 - "Within the chemical library, the natural flavonoid luteolin was identified as a potent cytotoxic agent against oral cancer cells in vitro, along with metixene hydrochloride and nitazoxanide. "

Related Drugs and Biologics

1.	Luteolin
2.	Caspases
3.	Flavonoids
4.	Cytotoxins (Cytolysins)
5.	Caffeine (No Doz)
6.	Analgesics (Analgesic Drugs)
7.	chlorphenoxamine
8.	nitazoxanide (NTZ)

Related Therapies and Procedures

1.	Therapeutics